LOCUS NP_001265651 504 aa linear PRI 30-DEC-2022
DEFINITION interleukin-20 receptor subunit alpha isoform 2 [Homo sapiens].
ACCESSION NP_001265651
VERSION NP_001265651.2
DBSOURCE REFSEQ: accession NM_001278722.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 504)
AUTHORS Lamichhane S, Mo JS, Sharma G, Choi TY and Chae SC.
TITLE MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in
inflammatory colitis and colorectal cancer
JOURNAL Inflamm Res 70 (8), 903-914 (2021)
PUBMED 34283251
REMARK GeneRIF: MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway
in inflammatory colitis and colorectal cancer.
REFERENCE 2 (residues 1 to 504)
AUTHORS Gao W, Wen H, Liang L, Dong X, Du R, Zhou W, Zhang X, Zhang C,
Xiang R and Li N.
TITLE IL20RA signaling enhances stemness and promotes the formation of an
immunosuppressive microenvironment in breast cancer
JOURNAL Theranostics 11 (6), 2564-2580 (2021)
PUBMED 33456560
REMARK GeneRIF: IL20RA signaling enhances stemness and promotes the
formation of an immunosuppressive microenvironment in breast
cancer.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 504)
AUTHORS Zahradnik J, Kolarova L, Peleg Y, Kolenko P, Svidenska S,
Charnavets T, Unger T, Sussman JL and Schneider B.
TITLE Flexible regions govern promiscuous binding of IL-24 to receptors
IL-20R1 and IL-22R1
JOURNAL FEBS J 286 (19), 3858-3873 (2019)
PUBMED 31152679
REMARK GeneRIF: Multiple sequence alignment explains the stabilizing
effect of the mutated residues in the IL-24 variants by their
presence in the related and more stable cytokines IL-20 and IL-19
REFERENCE 4 (residues 1 to 504)
AUTHORS Wu J, Yang S, Yu D, Gao W, Liu X, Zhang K, Fu X, Bao W, Zhang K, Yu
J, Sun L and Wang S.
TITLE CRISPR/cas9 mediated knockout of an intergenic variant rs6927172
identified IL-20RA as a new risk gene for multiple autoimmune
diseases
JOURNAL Genes Immun 20 (2), 103-111 (2019)
PUBMED 29483615
REMARK GeneRIF: IL-20RA gene as a risk factor for multiple autoimmune
diseases.
REFERENCE 5 (residues 1 to 504)
AUTHORS McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D,
Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J,
Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre
S and Orozco G.
TITLE Capture Hi-C identifies a novel causal gene, IL20RA, in the
pan-autoimmune genetic susceptibility region 6q23
JOURNAL Genome Biol 17 (1), 212 (2016)
PUBMED 27799070
REMARK GeneRIF: the DNA fragment containing the associated SNPs interacts
through chromatin looping not only with TNFAIP3, but also with
IL20RA, located 680 kb upstream.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 504)
AUTHORS Pletnev S, Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A
and Zdanov A.
TITLE Characterization of the recombinant extracellular domains of human
interleukin-20 receptors and their complexes with interleukin-19
and interleukin-20
JOURNAL Biochemistry 42 (43), 12617-12624 (2003)
PUBMED 14580208
REMARK GeneRIF: forms stable complex with interleukin-19 and
interleukin-20 [IL-20R1][IL-20R2]
REFERENCE 7 (residues 1 to 504)
AUTHORS Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, Brandt C,
Jelinek L, Madden K, McKernan PA, Foster DC, Jaspers S and
Chandrasekher YA.
TITLE Interleukins 19, 20, and 24 signal through two distinct receptor
complexes. Differences in receptor-ligand interactions mediate
unique biological functions
JOURNAL J Biol Chem 277 (49), 47517-47523 (2002)
PUBMED 12351624
REFERENCE 8 (residues 1 to 504)
AUTHORS Wang M, Tan Z, Zhang R, Kotenko SV and Liang P.
TITLE Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric
receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
JOURNAL J Biol Chem 277 (9), 7341-7347 (2002)
PUBMED 11706020
REFERENCE 9 (residues 1 to 504)
AUTHORS Dumoutier L, Leemans C, Lejeune D, Kotenko SV and Renauld JC.
TITLE Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through
IL-20 receptor complexes of two types
JOURNAL J Immunol 167 (7), 3545-3549 (2001)
PUBMED 11564763
REFERENCE 10 (residues 1 to 504)
AUTHORS Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S,
Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L,
Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson
S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK,
Dale BA and Chandrasekher YA.
TITLE Interleukin 20: discovery, receptor identification, and role in
epidermal function
JOURNAL Cell 104 (1), 9-19 (2001)
PUBMED 11163236
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL135902.16.
On Aug 13, 2020 this sequence version replaced NP_001265651.1.
Summary: This gene encodes a member of the type II cytokine
receptor family. The encoded protein is a subunit of the receptor
for interleukin 20, a cytokine that may be involved in epidermal
function. The interleukin 20 receptor is a heterodimeric complex
consisting of the encoded protein and interleukin 20 receptor beta.
This gene and interleukin 20 receptor beta are highly expressed in
skin, and are upregulated in psoriasis. Alternative splicing
results in multiple transcript variants. [provided by RefSeq, Jul
2013].
Transcript Variant: This variant (2) contains an alternate 5'-most
exon, lacks a portion of the 5' coding region, and initiates
translation at a downstream start codon, compared to variant 1. The
encoded isoform (2) has a shorter N-terminus, compared to isoform
1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK297121.1, ERR4352443.482726.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1968189 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..504
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q23.3"
Protein 1..504
/product="interleukin-20 receptor subunit alpha isoform 2"
/note="interleukin-20 receptor I; class II cytokine
receptor ZCYTOR7; cytokine receptor family 2 member 8;
interleukin 20 receptor, alpha; interleukin 20 receptor
alpha subunit"
/calculated_mol_wt=57235
Region <1..74
/region_name="Tissue_fac"
/note="Tissue factor; pfam01108"
/db_xref="CDD:426053"
Region 86..190
/region_name="Interfer-bind"
/note="Interferon-alpha/beta receptor, fibronectin type
III; pfam09294"
/db_xref="CDD:430508"
CDS 1..504
/gene="IL20RA"
/gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
/coded_by="NM_001278722.2:243..1757"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS64536.1"
/db_xref="GeneID:53832"
/db_xref="HGNC:HGNC:6003"
/db_xref="MIM:605620"
ORIGIN
1 mknvlqwtpp eglqgvkvty tvqyfiygqk kwlnksecrn inrtycdlsa etsdyehqyy
61 akvkaiwgtk cskwaesgrf ypfletqigp pevalttdek sisvvltape kwkrnpedlp
121 vsmqqiysnl kynvsvlntk snrtwsqcvt nhtlvltwle pntlycvhve sfvpgpprra
181 qpsekqcart lkdqssefka kiifwyvlpv sitvflfsvm gysiyryihv gkekhpanli
241 liygnefdkr ffvpaekivi nfitlnisdd skishqdmsl lgkssdvssl ndpqpsgnlr
301 ppqeeeevkh lgyashlmei fcdseenteg tsltqqesls rtippdktvi eyeydvrttd
361 icagpeeqel slqeevstqg tllesqaala vlgpqtlqys ytpqlqdldp laqehtdsee
421 gpeeepsttl vdwdpqtgrl cipslssfdq dsegcepseg dglgeeglls rlyeepapdr
481 ppgenetylm qfmeewglyv qmen
//