LOCUS NP_001297255 167 aa linear PRI 20-NOV-2023
DEFINITION ubiquitin-conjugating enzyme E2 T isoform 2 [Homo sapiens].
ACCESSION NP_001297255
VERSION NP_001297255.1
DBSOURCE REFSEQ: accession NM_001310326.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 167)
AUTHORS de Carvalho LGA, Komoto TT, Moreno DA, Goes JVC, de Oliveira RTG,
de Lima Melo MM, Roa MEGV, Goncalves PG, Montefusco-Pereira CV,
Pinheiro RF and Ribeiro Junior HL.
TITLE USP15-USP7 Axis and UBE2T Differential Expression May Predict
Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm
JOURNAL Int J Mol Sci 24 (12), 10058 (2023)
PUBMED 37373211
REMARK GeneRIF: USP15-USP7 Axis and UBE2T Differential Expression May
Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic
Neoplasm.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 167)
AUTHORS Wang Y, Gao G, Wei X, Zhang Y and Yu J.
TITLE UBE2T Promotes Temozolomide Resistance of Glioblastoma Through
Regulating the Wnt/beta-Catenin Signaling Pathway
JOURNAL Drug Des Devel Ther 17, 1357-1369 (2023)
PUBMED 37181827
REMARK GeneRIF: UBE2T Promotes Temozolomide Resistance of Glioblastoma
Through Regulating the Wnt/beta-Catenin Signaling Pathway.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 167)
AUTHORS Ma N, Li Z, Yan J, Liu X, He L, Xie R and Lu X.
TITLE Diverse roles of UBE2T in cancer (Review)
JOURNAL Oncol Rep 49 (4) (2023)
PUBMED 36825587
REMARK GeneRIF: Diverse roles of UBE2T in cancer (Review).
REFERENCE 4 (residues 1 to 167)
AUTHORS Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J
and Yang L.
TITLE UBE2T promotes glioblastoma malignancy through
ubiquitination-mediated degradation of RPL6
JOURNAL Cancer Sci 114 (2), 521-532 (2023)
PUBMED 36156329
REMARK GeneRIF: UBE2T promotes glioblastoma malignancy through
ubiquitination-mediated degradation of RPL6.
REFERENCE 5 (residues 1 to 167)
AUTHORS Cao K, Ling X, Jiang X, Ma J and Zhu J.
TITLE Pan-cancer analysis of UBE2T with a focus on prognostic and
immunological roles in lung adenocarcinoma
JOURNAL Respir Res 23 (1), 306 (2022)
PUBMED 36357897
REMARK GeneRIF: Pan-cancer analysis of UBE2T with a focus on prognostic
and immunological roles in lung adenocarcinoma.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 167)
AUTHORS Hao J, Xu A, Xie X, Hao J, Tian T, Gao S, Xiao X and He D.
TITLE Elevated expression of UBE2T in lung cancer tumors and cell lines
JOURNAL Tumour Biol 29 (3), 195-203 (2008)
PUBMED 18667844
REMARK GeneRIF: UBE2T was significantly upregulated in lung cancer tissue
and cell lines, suggesting involvement of UBE2T in the malignant
cell phenotype.
REFERENCE 7 (residues 1 to 167)
AUTHORS Alpi A, Langevin F, Mosedale G, Machida YJ, Dutta A and Patel KJ.
TITLE UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited
independently to chromatin: a basis for the regulation of FANCD2
monoubiquitination
JOURNAL Mol Cell Biol 27 (24), 8421-8430 (2007)
PUBMED 17938197
REFERENCE 8 (residues 1 to 167)
AUTHORS Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD
and Dutta A.
TITLE UBE2T is the E2 in the Fanconi anemia pathway and undergoes
negative autoregulation
JOURNAL Mol Cell 23 (4), 589-596 (2006)
PUBMED 16916645
REMARK GeneRIF: UBE2T is the ubiquitin-conjugating enzyme (E2) in the
Fanconi anemia pathway and has a self-inactivation mechanism that
could be important for negative regulation of the Fanconi anemia
pathway.
REFERENCE 9 (residues 1 to 167)
AUTHORS Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH,
Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong
R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM,
Huang GY, Chen Z, Chen MD and Chen JL.
TITLE Gene expression profiling in the human
hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
JOURNAL Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
PUBMED 10931946
REFERENCE 10 (residues 1 to 167)
AUTHORS Mehta,P.A. and Ebens,C.
TITLE Fanconi Anemia
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
Gripp KW and Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 20301575
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP244265.1, BM460257.1 and
AF161499.1.
Summary: The protein encoded by this gene catalyzes the covalent
attachment of ubiquitin to protein substrates. Defects in this gene
have been associated with Fanconi anemia of complementation group
T. Two transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Jul 2015].
Transcript Variant: This variant (2) uses an alternate splice
junction in a 5' exon and initiates translation at an alternate
start codon compared to variant 1. The resulting isoform (2) has a
shorter and distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BM460257.1, SRR7346977.376159.1
[ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..167
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32.1"
Protein 1..167
/product="ubiquitin-conjugating enzyme E2 T isoform 2"
/EC_number="2.3.2.23"
/note="HSPC150 protein similar to ubiquitin-conjugating
enzyme; ubiquitin-protein ligase T; ubiquitin carrier
protein T; cell proliferation-inducing gene 50 protein;
ubiquitin conjugating enzyme E2T; ubiquitin-conjugating
enzyme E2T (putative); E2 ubiquitin-conjugating enzyme T"
/calculated_mol_wt=18847
Region <6..117
/region_name="UBCc"
/note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
domain. This is part of the ubiquitin-mediated protein
degradation pathway in which a thiol-ester linkage forms
between a conserved cysteine and the C-terminus of
ubiquitin and complexes with ubiquitin...; cd00195"
/db_xref="CDD:238117"
Site order(32..33,70..71)
/site_type="active"
/note="E3 interaction residues [active]"
/db_xref="CDD:238117"
Site order(43..44,48..49,51,55..57,59..60,68..69,72,77,80,83,
86..87,89,91..92)
/site_type="active"
/note="Ub thioester intermediate interaction residues
[active]"
/db_xref="CDD:238117"
Site 56
/site_type="active"
/note="active site cysteine"
/db_xref="CDD:238117"
CDS 1..167
/gene="UBE2T"
/gene_synonym="FANCT; HSPC150; PIG50"
/coded_by="NM_001310326.2:201..704"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="GeneID:29089"
/db_xref="HGNC:HGNC:25009"
/db_xref="MIM:610538"
ORIGIN
1 mtcelveilg gantpyekgv fkleviiper ypfeppqirf ltpiyhpnid sagricldvl
61 klppkgawrp slniatvlts iqllmsepnp ddplmadiss efkynkpafl knarqwtekh
121 arqkqkadee emldnlpeag dsrvhnstqk rkasqlvgie kkfhpdv
//