LOCUS NP_002820 913 aa linear PRI 24-DEC-2022
DEFINITION tyrosine-protein phosphatase non-receptor type 3 isoform 1 [Homo
sapiens].
ACCESSION NP_002820
VERSION NP_002820.3
DBSOURCE REFSEQ: accession NM_002829.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 913)
AUTHORS Onishi H, Iwamoto N, Sakanashi K, Koga S, Oyama Y, Yanai K,
Nakamura K, Nagai S, Fujimura A, Nakayama K, Ozono K and Yamasaki
A.
TITLE PTPN3 Could Betae a Therapeutic Target of Pancreatic Cancer
JOURNAL Anticancer Res 42 (6), 2869-2874 (2022)
PUBMED 35641270
REMARK GeneRIF: PTPN3 Could Betae a Therapeutic Target of Pancreatic
Cancer.
REFERENCE 2 (residues 1 to 913)
AUTHORS Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz
A, Mechaly A, Matondo M, Duchateau M, Konig A, Windisch MP, Neuveut
C, Wolff N and Caillet-Saguy C.
TITLE Molecular basis of the interaction of the human tyrosine
phosphatase PTPN3 with the hepatitis B virus core protein
JOURNAL Sci Rep 11 (1), 944 (2021)
PUBMED 33441627
REMARK GeneRIF: Molecular basis of the interaction of the human tyrosine
phosphatase PTPN3 with the hepatitis B virus core protein.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 913)
AUTHORS Nakayama K, Onishi H, Fujimura A, Imaizumi A, Kawamoto M, Oyama Y,
Ichimiya S, Koga S, Fujimoto Y, Nakashima K and Nakamura M.
TITLE NFkappaB and TGFbeta contribute to the expression of PTPN3 in
activated human lymphocytes
JOURNAL Cell Immunol 358, 104237 (2020)
PUBMED 33137650
REMARK GeneRIF: NFkappaB and TGFbeta contribute to the expression of PTPN3
in activated human lymphocytes.
REFERENCE 4 (residues 1 to 913)
AUTHORS Peng XS, Yang JP, Qiang YY, Sun R, Cao Y, Zheng LS, Peng LX, Lang
YH, Mei Y, Li CZ, Meng DF, Liu ZJ, Wang MD, Zhou FJ, Huang BJ and
Qian CN.
TITLE PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell
Carcinoma via Inhibition of PI3K/AKT Signaling
JOURNAL Mol Cancer Res 18 (6), 903-912 (2020)
PUBMED 32169891
REMARK GeneRIF: PTPN3 Inhibits the Growth and Metastasis of Clear Cell
Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
REFERENCE 5 (residues 1 to 913)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 6 (residues 1 to 913)
AUTHORS Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H and Tonks NK.
TITLE Serine phosphorylation-dependent association of the band
4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta
protein
JOURNAL J Biol Chem 272 (43), 27281-27287 (1997)
PUBMED 9341175
REFERENCE 7 (residues 1 to 913)
AUTHORS Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K and Yachi
A.
TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase
PTPH1 mRNA in human hepatocellular carcinoma
JOURNAL J Gastroenterol 29 (6), 727-732 (1994)
PUBMED 7874267
REFERENCE 8 (residues 1 to 913)
AUTHORS Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T,
Inazawa J, Imai K and Yachi A.
TITLE Expression and chromosomal assignment of PTPH1 gene encoding a
cytosolic protein tyrosine phosphatase homologous to
cytoskeletal-associated proteins
JOURNAL Int J Cancer 55 (6), 947-951 (1993)
PUBMED 8253532
REFERENCE 9 (residues 1 to 913)
AUTHORS Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M,
Imai K and Yachi A.
TITLE cDNA cloning of new protein tyrosine phosphatases in the human
colon
JOURNAL Tumour Biol 13 (3), 180-186 (1992)
PUBMED 1626183
REFERENCE 10 (residues 1 to 913)
AUTHORS Yang Q and Tonks NK.
TITLE Isolation of a cDNA clone encoding a human protein-tyrosine
phosphatase with homology to the cytoskeletal-associated proteins
band 4.1, ezrin, and talin
JOURNAL Proc Natl Acad Sci U S A 88 (14), 5949-5953 (1991)
PUBMED 1648725
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK316066.1, BC126117.1,
BC033716.1, DB173093.1, AK096975.1 and AL359963.29.
This sequence is a reference standard in the RefSeqGene project.
On Feb 21, 2009 this sequence version replaced NP_002820.2.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This protein contains a C-terminal PTP
domain and an N-terminal domain homologous to the band 4.1
superfamily of cytoskeletal-associated proteins. P97, a cell cycle
regulator involved in a variety of membrane related functions, has
been shown to be a substrate of this PTP. This PTP was also found
to interact with, and be regulated by adaptor protein 14-3-3 beta.
Several alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Feb 2009].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660807.75211.1,
SRR7346977.2885267.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000374541.4/ ENSP00000363667.1
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..913
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q31.3"
Protein 1..913
/product="tyrosine-protein phosphatase non-receptor type 3
isoform 1"
/EC_number="3.1.3.48"
/note="cytoskeletal-associated protein tyrosine
phosphatase; protein-tyrosine phosphatase H1"
/calculated_mol_wt=103859
Region 31..222
/region_name="B41"
/note="Band 4.1 homologues; smart00295"
/db_xref="CDD:214604"
Region 216..309
/region_name="FERM_C_PTPN4_PTPN3_like"
/note="FERM domain C-lobe of Protein tyrosine phosphatase
non-receptor proteins 3 and 4 (PTPN4 and PTPN3); cd13189"
/db_xref="CDD:270010"
Site order(226,243,245,251)
/site_type="other"
/note="putative phosphoinositide binding site [chemical
binding]"
/db_xref="CDD:270010"
Site order(255,260..263,298,302,305..306)
/site_type="other"
/note="putative peptide binding site [polypeptide
binding]"
/db_xref="CDD:270010"
Site 298..309
/site_type="other"
/note="putative actin binding site 2 [polypeptide
binding]"
/db_xref="CDD:270010"
Site 357
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Site 359
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Region 363..400
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P26045.2)"
Site 367
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Site 376
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Site 381
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Region 420..475
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P26045.2)"
Site 425
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (P26045.2)"
Region 508..595
/region_name="PDZ_signaling"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; cd00992"
/db_xref="CDD:238492"
Site order(520..523,525,575..576,579..580)
/site_type="other"
/note="protein binding site [polypeptide binding]"
/db_xref="CDD:238492"
Region 631..904
/region_name="PTPc-N3"
/note="catalytic domain of tyrosine-protein phosphatase
non-receptor type 3; cd14600"
/db_xref="CDD:350448"
CDS 1..913
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/coded_by="NM_002829.4:107..2848"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS6776.1"
/db_xref="GeneID:5774"
/db_xref="HGNC:HGNC:9655"
/db_xref="MIM:176877"
ORIGIN
1 mtsrlralgg rinnirtsel pkektrsevi csihfldgvv qtfkvtkqdt gqvlldmvhn
61 hlgvtekeyf glqhdddsvd sprwleaska irkqlkggfp ctlhfrvrff ipdpntlqqe
121 qtrhlyflql kmdicegrlt cplnsavvla syavqshfgd ynssihhpgy lsdshfipdq
181 nedfltkves lheqhsglkq seaescyini artldfygve lhsgrdlhnl dlmigiasag
241 vavyrkyict sfypwvnilk isfkrkkffi hqrqkqaesr ehivafnmln yrscknlwks
301 cvehhtffqa kkllpqeknv lsqywtmgsr ntkksvnnqy ckkviggmvw npamrrslsv
361 ehletkslps rsppitpnwr sprlrheirk prhssadnla nemtyitete dvfytykgsl
421 apqdsdsevs qnrsphqesl sennpaqsyl tqkssssvsp ssnapgscsp dgvdqqlldd
481 fhrvtkggst edasqyycdk ndngdsylvl iritpdedgk fgfnlkggvd qkmplvvsri
541 npespadtci pklnegdqiv lingrdiseh thdqvvmfik asreshsrel alvirrravr
601 sfadfksede lnqlfpeaif pmcpeggdtl egsmaqlkkg lesgtvliqf eqlyrkkpgl
661 aitfaklpqn ldknrykdvl pydttrvllq gnedyinasy vnmeipaanl vnkyiatqgp
721 lphtcaqfwq vvwdqklsli vmlttlterg rtkchqywpd ppdvmnhggf hiqcqsedct
781 iayvsremlv tntqtgeeht vthlqyvawp dhgvpddssd flefvnyvrs lrvdsepvlv
841 hcsagigrtg vlvtmetamc lternlpiyp ldivrkmrdq rammvqtssq ykfvceailr
901 vyeeglvqml dps
//
