LOCUS NP_005943 61 aa linear PRI 24-DEC-2022
DEFINITION metallothionein-1X [Homo sapiens].
ACCESSION NP_005943
VERSION NP_005943.1
DBSOURCE REFSEQ: accession NM_005952.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 61)
AUTHORS Ding Y, Fang J, Chen M, Xu Y, Liu N, Fang S, Xiang W, Chen R, Wu C
and Yu H.
TITLE MT1X is an oncogene and indicates prognosis in ccRCC
JOURNAL Biosci Rep 42 (10) (2022)
PUBMED 36149322
REMARK GeneRIF: MT1X is an oncogene and indicates prognosis in ccRCC.
REFERENCE 2 (residues 1 to 61)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 3 (residues 1 to 61)
AUTHORS Masiulionyte B, Valiulyte I, Tamasauskas A and Skiriute D.
TITLE Metallothionein Genes are Highly Expressed in Malignant
Astrocytomas and Associated with Patient Survival
JOURNAL Sci Rep 9 (1), 5406 (2019)
PUBMED 30932010
REMARK GeneRIF: Metallothionein Genes are Highly Expressed in Malignant
Astrocytomas and Associated with Patient Survival.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 61)
AUTHORS Liu Z, Ye Q, Wu L, Gao F, Xie H, Zhou L, Zheng S and Xu X.
TITLE Metallothionein 1 family profiling identifies MT1X as a tumor
suppressor involved in the progression and metastastatic capacity
of hepatocellular carcinoma
JOURNAL Mol Carcinog 57 (11), 1435-1444 (2018)
PUBMED 29873415
REMARK GeneRIF: we featured the expression patterns of MT1s in tissue
obtained from various points along the spectrum of
hepatocarcinogenesis. Most MT1 members were down-regulated, and
MT1X were associated with HCC prognosis. Additionally, MT1X was
shown to play a suppressive role in HCC metastasis.
REFERENCE 5 (residues 1 to 61)
AUTHORS Farahani N, Nikpou P, Emami MH, Hashemzadeh M, Zeinalian M,
Shariatpanahi SS and Salehi R.
TITLE Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide
Marker for Characterizing Microsatellite Instability in Persian
Lynch Syndrome Patients
JOURNAL Asian Pac J Cancer Prev 17 (9), 4259-4265 (2016)
PUBMED 27797228
REMARK GeneRIF: MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker
showing Microsatellite Instability is associated with Persian Lynch
Syndrome
REFERENCE 6 (residues 1 to 61)
AUTHORS Holloway AF, Stennard FA and West AK.
TITLE Human metallothionein gene MT1L mRNA is present in several human
tissues but is unlikely to produce a metallothionein protein
JOURNAL FEBS Lett 404 (1), 41-44 (1997)
PUBMED 9074634
REFERENCE 7 (residues 1 to 61)
AUTHORS Mididoddi S, McGuirt JP, Sens MA, Todd JH and Sens DA.
TITLE Isoform-specific expression of metallothionein mRNA in the
developing and adult human kidney
JOURNAL Toxicol Lett 85 (1), 17-27 (1996)
PUBMED 8619255
REFERENCE 8 (residues 1 to 61)
AUTHORS Stennard FA, Holloway AF, Hamilton J and West AK.
TITLE Characterisation of six additional human metallothionein genes
JOURNAL Biochim Biophys Acta 1218 (3), 357-365 (1994)
PUBMED 8049263
REFERENCE 9 (residues 1 to 61)
AUTHORS Pauwels M, van Weyenbergh J, Soumillion A, Proost P and De Ley M.
TITLE Induction by zinc of specific metallothionein isoforms in human
monocytes
JOURNAL Eur J Biochem 220 (1), 105-110 (1994)
PUBMED 8119276
REFERENCE 10 (residues 1 to 61)
AUTHORS West AK, Stallings R, Hildebrand CE, Chiu R, Karin M and Richards
RI.
TITLE Human metallothionein genes: structure of the functional locus at
16q13
JOURNAL Genomics 8 (3), 513-518 (1990)
PUBMED 2286373
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CD101947.1 and BC032338.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: HM005437.1, CD101947.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000394485.5/ ENSP00000377995.4
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..61
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q13"
Protein 1..61
/product="metallothionein-1X"
/note="MT-1X; MT-IX; metallothionein-IX; testicular tissue
protein Li 124"
/calculated_mol_wt=5937
Region 1..29
/region_name="Beta"
/note="propagated from UniProtKB/Swiss-Prot (P80297.1)"
Site 1
/site_type="acetylation"
/note="N-acetylmethionine.
/evidence=ECO:0007744|PubMed:19413330; propagated from
UniProtKB/Swiss-Prot (P80297.1)"
Region 4..61
/region_name="Metallothio"
/note="Metallothionein; pfam00131"
/db_xref="CDD:395080"
Region 30..61
/region_name="Alpha"
/note="propagated from UniProtKB/Swiss-Prot (P80297.1)"
Site 58
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P02795; propagated from
UniProtKB/Swiss-Prot (P80297.1)"
CDS 1..61
/gene="MT1X"
/gene_synonym="MT-1l; MT1"
/coded_by="NM_005952.4:72..257"
/db_xref="CCDS:CCDS10768.1"
/db_xref="GeneID:4501"
/db_xref="HGNC:HGNC:7405"
/db_xref="MIM:156359"
ORIGIN
1 mdpncscspv gscacagsck ckeckctsck ksccsccpvg cakcaqgcic kgtsdkcscc
61 a
//
