LOCUS NP_035299 608 aa linear ROD 14-APR-2013
DEFINITION prolactin receptor isoform 1 precursor [Mus musculus].
ACCESSION NP_035299 NP_032958 NP_849252
VERSION NP_035299.4 GI:254675324
DBSOURCE REFSEQ: accession NM_011169.5
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 608)
AUTHORS Chen,C.C., Stairs,D.B., Boxer,R.B., Belka,G.K., Horseman,N.D.,
Alvarez,J.V. and Chodosh,L.A.
TITLE Autocrine prolactin induced by the Pten-Akt pathway is required for
lactation initiation and provides a direct link between the Akt and
Stat5 pathways
JOURNAL Genes Dev. 26 (19), 2154-2168 (2012)
PUBMED 23028142
REFERENCE 2 (residues 1 to 608)
AUTHORS Auffret,J., Viengchareun,S., Carre,N., Denis,R.G., Magnan,C.,
Marie,P.Y., Muscat,A., Feve,B., Lombes,M. and Binart,N.
TITLE Beige differentiation of adipose depots in mice lacking prolactin
receptor protects against high-fat-diet-induced obesity
JOURNAL FASEB J. 26 (9), 3728-3737 (2012)
PUBMED 22637534
REMARK GeneRIF: results provide direct genetic evidence that PRLR affects
energy balance and metabolic adaptation in rodents via effects on
brown adipose tissue differentiation and function
REFERENCE 3 (residues 1 to 608)
AUTHORS Oliver,C.H., Khaled,W.T., Frend,H., Nichols,J. and Watson,C.J.
TITLE The Stat6-regulated KRAB domain zinc finger protein Zfp157
regulates the balance of lineages in mammary glands and compensates
for loss of Gata-3
JOURNAL Genes Dev. 26 (10), 1086-1097 (2012)
PUBMED 22588720
REFERENCE 4 (residues 1 to 608)
AUTHORS Tabata,H., Kobayashi,M., Ikeda,J.H., Nakao,N., Saito,T.R. and
Tanaka,M.
TITLE Characterization of multiple first exons in murine prolactin
receptor gene and the effect of prolactin on their expression in
the choroid plexus
JOURNAL J. Mol. Endocrinol. 48 (2), 169-176 (2012)
PUBMED 22294444
REMARK GeneRIF: Data suggest that PRL stimulates the Prlr gene expression
through the transcriptional activation of mE1(4) first exon,
leading to increases in the long- and short-form variants of Prlr
mRNA in the murine choroid plexus.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 608)
AUTHORS Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
Talianidis,I. and Garinis,G.A.
TITLE Defective transcription initiation causes postnatal growth failure
in a mouse model of nucleotide excision repair (NER) progeria
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (8), 2995-3000 (2012)
PUBMED 22323595
REFERENCE 6 (residues 1 to 608)
AUTHORS Gala,R.R.
TITLE Influence of thyroxine and thyroxine with growth hormone and
prolactin on splenocyte subsets and on the expression of
interleukin-2 and prolactin receptors on splenocyte subsets of
Snell dwarf mice
JOURNAL Proc. Soc. Exp. Biol. Med. 210 (2), 117-125 (1995)
PUBMED 7568281
REFERENCE 7 (residues 1 to 608)
AUTHORS Barker,C.S., Bear,S.E., Keler,T., Copeland,N.G., Gilbert,D.J.,
Jenkins,N.A., Yeung,R.S. and Tsichlis,P.N.
TITLE Activation of the prolactin receptor gene by promoter insertion in
a Moloney murine leukemia virus-induced rat thymoma
JOURNAL J. Virol. 66 (11), 6763-6768 (1992)
PUBMED 1404614
REFERENCE 8 (residues 1 to 608)
AUTHORS Davis,J.A. and Linzer,D.I.
TITLE Mutational analysis of mouse placental lactogen II, and molecular
characterization of the mouse prolactin receptor
JOURNAL Prog. Clin. Biol. Res. 342, 127-132 (1990)
PUBMED 2381944
REFERENCE 9 (residues 1 to 608)
AUTHORS Davis,J.A. and Linzer,D.I.
TITLE Expression of multiple forms of the prolactin receptor in mouse
liver
JOURNAL Mol. Endocrinol. 3 (4), 674-680 (1989)
PUBMED 2725531
REFERENCE 10 (residues 1 to 608)
AUTHORS Herington,A.C., Harrison,D. and Graystone,J.
TITLE Hepatic binding of human and bovine growth hormones and ovine
prolactin in the dwarf 'little' mouse
JOURNAL Endocrinology 112 (6), 2032-2038 (1983)
PUBMED 6303755
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK054551.1, AK052679.1, AK077980.1, BG087509.2, DV053280.1,
AK087727.1, AK165113.1, AK087749.1, AK083198.1 and AI527408.1.
On Jul 24, 2009 this sequence version replaced gi:34328491.
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC005555.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..608
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="15"
/map="15 5.23 cM"
Protein 1..608
/product="prolactin receptor isoform 1 precursor"
/note="prolactin receptor related sequence 1; PRL-R"
sig_peptide 1..19
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=1996
variation 2
/replace="p"
/db_xref="dbSNP:13462439"
Region 18..115
/region_name="EpoR_lig-bind"
/note="Erythropoietin receptor, ligand binding; pfam09067"
/db_xref="CDD:149944"
mat_peptide 20..608
/product="Prolactin receptor"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q08501.1)"
/calculated_mol_wt=66263
variation 47
/replace="a"
/db_xref="dbSNP:257336759"
Region 122..219
/region_name="FN3"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; cd00063"
/db_xref="CDD:28945"
Site order(122,193,208)
/site_type="other"
/note="Interdomain contacts"
/db_xref="CDD:28945"
variation 147
/replace="f"
/db_xref="dbSNP:226198648"
Region 210..214
/region_name="WSXWS motif"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q08501.1)"
Site order(210..211,213..214)
/site_type="other"
/note="Cytokine receptor motif"
/db_xref="CDD:28945"
Site 230..253
/site_type="transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q08501.1)"
Region 262..270
/region_name="Box 1 motif"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q08501.1)"
variation 324
/replace="r"
/db_xref="dbSNP:46169444"
variation 386
/replace="s"
/db_xref="dbSNP:219509266"
variation 393
/replace="s"
/db_xref="dbSNP:240156909"
variation 416
/replace="m"
/db_xref="dbSNP:257265194"
variation 417
/replace="p"
/db_xref="dbSNP:48303459"
variation 466
/replace="r"
/db_xref="dbSNP:51486556"
variation 476
/replace="s"
/db_xref="dbSNP:45960064"
variation 488
/replace="t"
/db_xref="dbSNP:245602662"
variation 580
/replace="n"
/db_xref="dbSNP:49619480"
CDS 1..608
/gene="Prlr"
/gene_synonym="AI987712; Pr-1; Pr-3; Prlr-rs1"
/coded_by="NM_011169.5:749..2575"
/note="isoform 1 precursor is encoded by transcript
variant 1"
/db_xref="CCDS:CCDS27377.1"
/db_xref="GeneID:19116"
/db_xref="MGI:97763"
ORIGIN
1 mssalaymll vlsisllngq sppgkpeihk crspdketft cwwnpgsdgg lptnysltys
61 kegekntyec pdyktsgpns cffskqytsi wkiyiitvna tnemgsstsd plyvdvtyiv
121 epepprnltl evkqlkdkkt ylwvkwlppt itdvktgwft meyeirlkse eadeweihft
181 ghqtqfkvfd lypgqkylvq trckpdhgyw srwgqeksie ipndftlkdt tvwiivavls
241 aviclimvwa valkgysmmt cifppvpgpk ikgfdthlle kgkseellsa lgcqdfppts
301 dcedllvefl evddnederl mpshskeypg qgvkpthldp dsdsghgsyd shsllsekce
361 epqayppafh ipeitekpen peanipptpn pqnntpncht dtsksttwpl ppgqhtrrsp
421 yhsiadvckl agspgdtlds fldkaeenvl klsedageee vavqegaksf psdkqntswp
481 plqekgpivy akppdyveih kvnkdgvlsl lpkqrenhqt enpgvpetsk eyakvsgvtd
541 nnilvlvpds raqntallee sakkvppsle qnqsekdlas ftatssncrl qlgrldyldp
601 tcfmhsfh
//
