LOCUS NP_058616 838 aa linear ROD 02-MAR-2023
DEFINITION V-type proton ATPase 116 kDa subunit a 1 isoform 1 [Mus musculus].
ACCESSION NP_058616
VERSION NP_058616.1
DBSOURCE REFSEQ: accession NM_016920.5
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 838)
AUTHORS Zapata RC, Carretero M, Reis FCG, Chaudry BS, Ofrecio J, Zhang D,
Sasik R, Ciaraldi T, Petrascheck M and Osborn O.
TITLE Adipocytes control food intake and weight regain via Vacuolar-type
H+ ATPase
JOURNAL Nat Commun 13 (1), 5092 (2022)
PUBMED 36042358
REMARK GeneRIF: Adipocytes control food intake and weight regain via
Vacuolar-type H(+) ATPase.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 838)
AUTHORS Sun-Wada GH and Wada Y.
TITLE The a subunit isoforms of vacuolar-type proton ATPase exhibit
differential distribution in mouse perigastrulation embryos
JOURNAL Sci Rep 12 (1), 13590 (2022)
PUBMED 35948619
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 838)
AUTHORS Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama
J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R,
Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A,
Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N and Saitsu
H.
TITLE ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar
H+-ATPases is essential for brain development in humans and mice
JOURNAL Nat Commun 12 (1), 2107 (2021)
PUBMED 33833240
REMARK GeneRIF: ATP6V0A1 encoding the a1-subunit of the V0 domain of
vacuolar H(+)-ATPases is essential for brain development in humans
and mice.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 838)
AUTHORS Castroflorio E, den Hoed J, Svistunova D, Finelli MJ,
Cebrian-Serrano A, Corrochano S, Bassett AR, Davies B and Oliver
PL.
TITLE The Ncoa7 locus regulates V-ATPase formation and function,
neurodevelopment and behaviour
JOURNAL Cell Mol Life Sci 78 (7), 3503-3524 (2021)
PUBMED 33340069
REFERENCE 5 (residues 1 to 838)
AUTHORS Ma K, Bin NR, Shi S, Harada H, Wada Y, Wada GH, Monnier PP, Sugita
S and Zhang L.
TITLE Observations From a Mouse Model of Forebrain Voa1 Knockout: Focus
on Hippocampal Structure and Function
JOURNAL Front Cell Neurosci 13, 484 (2019)
PUBMED 31824264
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 838)
AUTHORS Murata Y, Sun-Wada GH, Yoshimizu T, Yamamoto A, Wada Y and Futai M.
TITLE Differential localization of the vacuolar H+ pump with G subunit
isoforms (G1 and G2) in mouse neurons
JOURNAL J Biol Chem 277 (39), 36296-36303 (2002)
PUBMED 12133826
REFERENCE 7 (residues 1 to 838)
AUTHORS Sobacchi C, Frattini A, Orchard P, Porras O, Tezcan I, Andolina M,
Babul-Hirji R, Baric I, Canham N, Chitayat D, Dupuis-Girod S, Ellis
I, Etzioni A, Fasth A, Fisher A, Gerritsen B, Gulino V, Horwitz E,
Klamroth V, Lanino E, Mirolo M, Musio A, Matthijs G, Nonomaya S,
Notarangelo LD, Ochs HD, Superti Furga A, Valiaho J, van Hove JL,
Vihinen M, Vujic D, Vezzoni P and Villa A.
TITLE The mutational spectrum of human malignant autosomal recessive
osteopetrosis
JOURNAL Hum Mol Genet 10 (17), 1767-1773 (2001)
PUBMED 11532986
REFERENCE 8 (residues 1 to 838)
AUTHORS Toyomura T, Oka T, Yamaguchi C, Wada Y and Futai M.
TITLE Three subunit a isoforms of mouse vacuolar H(+)-ATPase.
Preferential expression of the a3 isoform during osteoclast
differentiation
JOURNAL J Biol Chem 275 (12), 8760-8765 (2000)
PUBMED 10722719
REFERENCE 9 (residues 1 to 838)
AUTHORS Nishi T and Forgac M.
TITLE Molecular cloning and expression of three isoforms of the 100-kDa a
subunit of the mouse vacuolar proton-translocating ATPase
JOURNAL J Biol Chem 275 (10), 6824-6830 (2000)
PUBMED 10702241
REFERENCE 10 (residues 1 to 838)
AUTHORS Mohlke KL, Purkayastha AA, Westrick RJ and Ginsburg D.
TITLE Comparative mapping of distal murine chromosome 11 and human
17q21.3 in a region containing a modifying locus for murine plasma
von Willebrand factor level
JOURNAL Genomics 54 (1), 19-30 (1998)
PUBMED 9806826
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL591425.4.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF218249.1, SRR17784645.60305.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849379
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..838
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 64.04 cM"
Protein 1..838
/product="V-type proton ATPase 116 kDa subunit a 1 isoform
1"
/EC_number="7.1.2.2"
/note="ATPase, H+ transporting, lysosomal V0 subunit a;
ATPase, H+ transporting, lysosomal (vacuolar proton pump)
noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+
transporting, lysosomal (vacuolar proton pump)
noncatalytic accessory protein 1A (110/160 kDa); V-type
proton ATPase 116 kDa subunit a; vacuolar proton pump
subunit 1; vacuolar adenosine triphosphatase subunit
Ac116; vacuolar proton translocating ATPase 116 kDa
subunit a; clathrin-coated vesicle/synaptic vesicle proton
pump 116 kDa subunit; V-ATPase a1; V-ATPase 116 kDa
subunit a1; V-type proton ATPase 116 kDa subunit a1;
V-ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa
subunit a 1"
/calculated_mol_wt=96163
Region 28..828
/region_name="V_ATPase_I"
/note="V-type ATPase 116kDa subunit family; pfam01496"
/db_xref="CDD:426290"
Site 250
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 360
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q93050; propagated from
UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 364
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0007744|PubMed:18034455; propagated from
UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 389..407
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 410..426
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 442..471
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 536..555
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 574..594
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 640..659
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 726..750
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
Site 772..810
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z1G4.3)"
CDS 1..838
/gene="Atp6v0a1"
/gene_synonym="ATP6a1; Atp6n1; Atp6n1a; Atpv0a1; Vpp-1;
Vpp1"
/coded_by="NM_016920.5:113..2629"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS25443.1"
/db_xref="GeneID:11975"
/db_xref="MGI:MGI:103286"
ORIGIN
1 mgelfrseem tlaqlflqse aayccvselg elgkvqfrdl npdvnvfqrk fvnevrrcee
61 mdrklrfvek eirkanipim dtgenpevpf prdmidlean fekienelke intnqealkr
121 nfleltelkf ilrktqqffd emadpdllee sssllepnem grgaplrlgf vagvinreri
181 ptfermlwrv crgnvflrqa eienpledpv tgdyvhksvf iiffqgdqlk nrvkkicegf
241 raslypcpet pqerkemasg vntriddlqm vlnqtedhrq rvlqaaakni rvwfikvrkm
301 kaiyhtlnlc nidvtqkcli aevwcpvtdl dsiqfalrrg tehsgstvps ilnrmqtnqt
361 pptynktnkf thgfqnivda ygigtyrein papytvitfp flfavmfgdf ghgilmtlfa
421 vwmvlresri lsqkhenemf smvfsgryii llmglfsiyt gliyndcfsk slnifgssws
481 vrpmftqgnw teetllgssv lqlnpaipgv fggpypfgid piwniatnkl tflnsfkmkm
541 svilgiihml fgvslslfnh iyfkkplniy fgfipeiifm sslfgylvil ifykwtayda
601 hssrnapsll ihfinmflfs ypesgnamly sgqkgiqcfl ivvamlcvpw mllfkplilr
661 hqylrkkhlg tlnfggirvg ngpteedaei iqhdqlsths edaeeptede vfdfgdtmvh
721 qaihtieycl gcisntasyl rlwalslaha qlsevlwtmv ihiglhvrsl agglglffif
781 aafatltvai llimeglsaf lhalrlhwve fqnkfytgtg fkflpfsfeh iregkfde
//
