LOCUS NP_060349 594 aa linear PRI 25-DEC-2022
DEFINITION zinc finger protein 416 isoform 1 [Homo sapiens].
ACCESSION NP_060349
VERSION NP_060349.1
DBSOURCE REFSEQ: accession NM_017879.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 594)
AUTHORS Gaudet P, Livstone MS, Lewis SE and Thomas PD.
TITLE Phylogenetic-based propagation of functional annotations within the
Gene Ontology consortium
JOURNAL Brief Bioinform 12 (5), 449-462 (2011)
PUBMED 21873635
REFERENCE 2 (residues 1 to 594)
AUTHORS Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler
G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG,
Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee
E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI,
Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C,
Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T,
Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB,
Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K,
Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T,
Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH,
Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson
A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M,
Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC,
Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL,
Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC,
Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M,
Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu
AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones
SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S
and Malek J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC003682.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC000130.1, SRR1660805.116016.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000196489.4/ ENSP00000196489.2
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..594
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.43"
Protein 1..594
/product="zinc finger protein 416 isoform 1"
/calculated_mol_wt=67057
Region 27..67
/region_name="KRAB"
/note="KRAB box; pfam01352"
/db_xref="CDD:426216"
Region 77..506
/region_name="COG5048"
/note="FOG: Zn-finger [General function prediction only]"
/db_xref="CDD:227381"
Region 247..264
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 272..292
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(272,275,288,292)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:275368"
Site order(277,279,281,283..284,287..288,291,305,307,311..312,
315..316,319,333,335,337,339..340,343..344,347)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 300..320
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 328..348
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 356..376
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 384..404
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 412..432
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 440..460
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(440,443,456,460)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:275368"
Region 468..488
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(468,471,484,488)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:275368"
Region <490..573
/region_name="SFP1"
/note="Putative transcriptional repressor regulating G2/M
transition [Transcription / Cell division and chromosome
partitioning]; COG5189"
/db_xref="CDD:227516"
Region 496..516
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(496,499,512,516)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:275368"
Site order(501,503,505,507..508,511..512,515,529,531,535..536,
539..540,543,557,559,561,563..564,567..568,571)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 524..544
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 552..572
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 569..594
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9BWM5.1)"
CDS 1..594
/gene="ZNF416"
/coded_by="NM_017879.3:208..1992"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS12954.1"
/db_xref="GeneID:55659"
/db_xref="HGNC:HGNC:20645"
ORIGIN
1 maaavlrdst svpvtaeakl mgftqgcvtf edvaiyfsqe ewglldeaqr llyrdvmlen
61 falitalvcw hgmedeetpe qsvsvegvpq vrtpeaspst qkiqscdmcv pfltdilhlt
121 dlpgqelylt gacavfhqdq khhsaekple sdmdkasfvq cclfhesgmp ftssevgkdf
181 laplgilqpq aianyekpnk iskceeafhv gishykwsqc rresshkhtf fhprvctgkr
241 lyesskcgka cccecslvql qrvhpgerpy ecsecgksfs qtshlndhrr ihtgerpyvc
301 gqcgksfsqr atlikhhrvh tgerpyecge cgksfsqssn liehcrihtg erpyecdecg
361 kafgskstlv rhqrthtgek pyecgecgkl frqsfslvvh qrihttarpy ecgqcgksfs
421 lkcgliqhql ihsgarpfec decgksfsqr ttlnkhhkvh taerpyvcge cgkafmfksk
481 lvrhqrthtg erpfecsecg kffrqsytlv ehqkihtglr pydcgqcgks fiqkssliqh
541 qvvhtgerpy ecgkcgksft qhsglilhrk shtverprds skcgkpyspr sniv
//
