LOCUS NP_065438 104 aa linear PRI 23-SEP-2023
DEFINITION acyl-CoA-binding protein isoform 1 [Homo sapiens].
ACCESSION NP_065438
VERSION NP_065438.1
DBSOURCE REFSEQ: accession NM_020548.9
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 104)
AUTHORS Montegut L, Abdellatif M, Motino O, Madeo F, Martins I, Quesada V,
Lopez-Otin C and Kroemer G.
TITLE Acyl coenzyme A binding protein (ACBP): An aging- and
disease-relevant 'autophagy checkpoint'
JOURNAL Aging Cell 22 (9), e13910 (2023)
PUBMED 37357988
REMARK GeneRIF: Acyl coenzyme A binding protein (ACBP): An aging- and
disease-relevant 'autophagy checkpoint'.
Review article
REFERENCE 2 (residues 1 to 104)
AUTHORS Duman C, Di Marco B, Nevedomskaya E, Ulug B, Lesche R, Christian S
and Alfonso J.
TITLE Targeting fatty acid oxidation via Acyl-CoA binding protein hinders
glioblastoma invasion
JOURNAL Cell Death Dis 14 (4), 296 (2023)
PUBMED 37120445
REMARK GeneRIF: Targeting fatty acid oxidation via Acyl-CoA binding
protein hinders glioblastoma invasion.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 104)
AUTHORS Piras M, Gerosa C, Fanni D, Cau F, Coni P, Murru R, Denotti G, Orru
G, Scano A, Ledda F, Van Eyken P, Coghe F, Faa G and Castagnola M.
TITLE Acyl-CoA binding protein (ACBP) is highly expressed in the
developing human kidney
JOURNAL Eur Rev Med Pharmacol Sci 26 (9), 3301-3309 (2022)
PUBMED 35587082
REMARK GeneRIF: Acyl-CoA binding protein (ACBP) is highly expressed in the
developing human kidney.
REFERENCE 4 (residues 1 to 104)
AUTHORS Conti E, Andreoni S, Tomaselli D, Storti B, Brovelli F, Acampora R,
Da Re F, Appollonio I, Ferrarese C and Tremolizzo L.
TITLE Serum DBI and biomarkers of neuroinflammation in Alzheimer's
disease and delirium
JOURNAL Neurol Sci 42 (3), 1003-1007 (2021)
PUBMED 32705487
REMARK GeneRIF: Serum DBI and biomarkers of neuroinflammation in
Alzheimer's disease and delirium.
REFERENCE 5 (residues 1 to 104)
AUTHORS Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC,
Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano
M, Aranda F, Ramirez-Pardo I, Lallement J, Denom J, Boedec E,
Gorwood P, Ramoz N, Clement K, Pelloux V, Rohia A, Pattou F,
Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F,
Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, Lopez-Otin
C, Magnan C and Kroemer G.
TITLE Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food
Intake and Obesity
JOURNAL Cell Metab 30 (4), 754-767 (2019)
PUBMED 31422903
REMARK GeneRIF: Acyl-CoA-Binding Protein Is a Lipogenic Factor that
Triggers Food Intake and Obesity.
Erratum:[Cell Metab. 2019 Dec 3;30(6):1171. PMID: 31801056]
REFERENCE 6 (residues 1 to 104)
AUTHORS Nitz I, Doring F, Schrezenmeir J and Burwinkel B.
TITLE Identification of new acyl-CoA binding protein transcripts in human
and mouse
JOURNAL Int J Biochem Cell Biol 37 (11), 2395-2405 (2005)
PUBMED 16055366
REMARK GeneRIF: Results identify new acyl-CoA binding protein transcripts
in human and mouse tissues, generated by alternative first exon
usage.
REFERENCE 7 (residues 1 to 104)
AUTHORS Todd S and Naylor SL.
TITLE New chromosomal mapping assignments for argininosuccinate
synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam
binding inhibitor gene
JOURNAL Somat Cell Mol Genet 18 (4), 381-385 (1992)
PUBMED 1440058
REFERENCE 8 (residues 1 to 104)
AUTHORS DeBernardi MA, Crowe RR, Mocchetti I, Shows TB, Eddy RL and Costa
E.
TITLE Chromosomal localization of the human diazepam binding inhibitor
gene
JOURNAL Proc Natl Acad Sci U S A 85 (17), 6561-6565 (1988)
PUBMED 3413112
REFERENCE 9 (residues 1 to 104)
AUTHORS Webb,N.R., Rose,T.M., Malik,N., Marquardt,H., Shoyab,M.,
Todaro,G.J. and Lee,D.C.
TITLE Bovine and human cDNA sequences encoding a putative benzodiazepine
receptor ligand
JOURNAL DNA 6 (1), 71-79 (1987)
PUBMED 2881742
REFERENCE 10 (residues 1 to 104)
AUTHORS Gray,P.W., Glaister,D., Seeburg,P.H., Guidotti,A. and Costa,E.
TITLE Cloning and expression of cDNA for human diazepam binding
inhibitor, a natural ligand of an allosteric regulatory site of the
gamma-aminobutyric acid type A receptor
JOURNAL Proc Natl Acad Sci U S A 83 (19), 7547-7551 (1986)
PUBMED 3020548
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC016736.6.
Summary: This gene encodes diazepam binding inhibitor, a protein
that is regulated by hormones and is involved in lipid metabolism
and the displacement of beta-carbolines and benzodiazepines, which
modulate signal transduction at type A gamma-aminobutyric acid
receptors located in brain synapses. The protein is conserved from
yeast to mammals, with the most highly conserved domain consisting
of seven contiguous residues that constitute the hydrophobic
binding site for medium- and long-chain acyl-Coenzyme A esters.
Diazepam binding inhibitor is also known to mediate the feedback
regulation of pancreatic secretion and the postprandial release of
cholecystokinin, in addition to its role as a mediator in
corticotropin-dependent adrenal steroidogenesis. Three pseudogenes
located on chromosomes 6, 8 and 16 have been identified. Multiple
transcript variants encoding different isoforms have been described
for this gene. [provided by RefSeq, Jul 2008].
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FM213124.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2153946 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..104
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q14.2"
Protein 1..104
/product="acyl-CoA-binding protein isoform 1"
/EC_number="3.4.17.3"
/note="diazepam binding inhibitor (GABA receptor
modulator, acyl-Coenzyme A binding protein); acyl-Coenzyme
A binding domain containing 1; cholecystokinin-releasing
peptide, trypsin-sensitive; endozepine; acyl coenzyme A
binding protein; epididymis secretory sperm binding
protein; acyl-CoA-binding protein; diazepam-binding
inhibitor; diazepam binding inhibitor (GABA receptor
modulator, acyl-CoA binding protein)"
/calculated_mol_wt=11662
Region 30..103
/region_name="ACBP"
/note="Acyl CoA binding protein (ACBP) binds thiol esters
of long fatty acids and coenzyme A in a one-to-one binding
mode with high specificity and affinity. Acyl-CoAs are
important intermediates in fatty lipid synthesis and fatty
acid degradation and play a...; cd00435"
/db_xref="CDD:238248"
Site order(30..31,33,36..37,39,42..43,45..46,49..50,67..68,
71..72,91)
/site_type="other"
/note="acyl-CoA binding pocket [chemical binding]"
/db_xref="CDD:238248"
Site order(31,46,49..50,72,91)
/site_type="other"
/note="CoA binding site [chemical binding]"
/db_xref="CDD:238248"
CDS 1..104
/gene="DBI"
/gene_synonym="ACBD1; ACBP; CCK-RP; EP"
/coded_by="NM_020548.9:136..450"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS2126.1"
/db_xref="GeneID:1622"
/db_xref="HGNC:HGNC:2690"
/db_xref="MIM:125950"
ORIGIN
1 mwgdlwllpp asanpgtgte aefekaaeev rhlktkpsde emlfiyghyk qatvgdinte
61 rpgmldftgk akwdawnelk gtskedamka yinkveelkk kygi
//
