LOCUS NP_112265 500 aa linear ROD 22-MAR-2023
DEFINITION 4-aminobutyrate aminotransferase, mitochondrial [Rattus
norvegicus].
ACCESSION NP_112265
VERSION NP_112265.1
DBSOURCE REFSEQ: accession NM_031003.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 500)
AUTHORS Shen J, Wang C, Ying J, Xu T, McAlinden A and O'Keefe RJ.
TITLE Inhibition of 4-aminobutyrate aminotransferase protects against
injury-induced osteoarthritis in mice
JOURNAL JCI Insight 4 (18), 128568 (2019)
PUBMED 31534049
REMARK GeneRIF: Inhibition of 4-aminobutyrate aminotransferase protects
against injury-induced osteoarthritis in mice.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 500)
AUTHORS Dieb W and Hafidi A.
TITLE Mechanism of GABA involvement in post-traumatic trigeminal
neuropathic pain: activation of neuronal circuitry composed of
PKCgamma interneurons and pERK1/2 expressing neurons
JOURNAL Eur J Pain 19 (1), 85-96 (2015)
PUBMED 24890317
REFERENCE 3 (residues 1 to 500)
AUTHORS Briggs SW, Mowrey W, Hall CB and Galanopoulou AS.
TITLE CPP-115, a vigabatrin analogue, decreases spasms in the
multiple-hit rat model of infantile spasms
JOURNAL Epilepsia 55 (1), 94-102 (2014)
PUBMED 24321005
REFERENCE 4 (residues 1 to 500)
AUTHORS De Ita-Perez D, Mendez I, Vazquez-Martinez O, Villalobos-Leal M and
Diaz-Munoz M.
TITLE Synchronization by food access modifies the daily variations in
expression and activity of liver GABA transaminase
JOURNAL Biomed Res Int 2014, 590581 (2014)
PUBMED 24809054
REMARK GeneRIF: Daytime restricted feeding influences the daily variations
of GABA-T mRNA levels, stability, and catalytic activity of GABA-T.
REFERENCE 5 (residues 1 to 500)
AUTHORS Yu X, He GR, Sun L, Lan X, Shi LL, Xuan ZH and Du GH.
TITLE Assessment of the treatment effect of baicalein on a model of
Parkinsonian tremor and elucidation of the mechanism
JOURNAL Life Sci 91 (1-2), 5-13 (2012)
PUBMED 22634324
REFERENCE 6 (residues 1 to 500)
AUTHORS Singewald N, Pfitscher A and Philippu A.
TITLE Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body
weight of hypertensive and normotensive rats
JOURNAL Naunyn Schmiedebergs Arch Pharmacol 345 (2), 181-186 (1992)
PUBMED 1570022
REFERENCE 7 (residues 1 to 500)
AUTHORS Sherif F, Gottfries CG, Alafuzoff I and Oreland L.
TITLE Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine
oxidase (MAO) in patients with Alzheimer's disease
JOURNAL J Neural Transm Park Dis Dement Sect 4 (3), 227-240 (1992)
PUBMED 1627256
REFERENCE 8 (residues 1 to 500)
AUTHORS Beeler,T. and Churchich,J.E.
TITLE 4-Aminobutyrate aminotransferase fluorescence studies
JOURNAL Eur J Biochem 85 (2), 365-371 (1978)
PUBMED 648527
REFERENCE 9 (residues 1 to 500)
AUTHORS Stoof,J.C. and Mulder,A.H.
TITLE Increased dopamine release from rat striatal slices by inhibitors
of GABA-aminotransferase
JOURNAL Eur J Pharmacol 46 (2), 177-180 (1977)
PUBMED 590329
REFERENCE 10 (residues 1 to 500)
AUTHORS Schwarcz,R., Bennett,J.P. Jr. and Coyle,J.T.
TITLE Inhibitors of GABA metabolism: implications for Huntington's
disease
JOURNAL Ann Neurol 2 (4), 299-303 (1977)
PUBMED 152600
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from D87839.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D87839.1, BC081787.1 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
RefSeq Select criteria :: based on conservation,
expression, longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..500
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="10"
/map="10q12"
Protein 1..500
/product="4-aminobutyrate aminotransferase, mitochondrial"
/EC_number="2.6.1.19"
/EC_number="2.6.1.22"
/note="GABA-T; GABA-AT; L-AIBAT; GABA transaminase;
gamma-amino-N-butyrate transaminase;
(S)-3-amino-2-methylpropionate transaminase; GABA
aminotransferase; beta-AlaAT I"
/calculated_mol_wt=53332
transit_peptide 1..27
/note="Mitochondrion; propagated from UniProtKB/Swiss-Prot
(P50554.3)"
/calculated_mol_wt=3141
Region 34..496
/region_name="GABAtrns_euk"
/note="4-aminobutyrate aminotransferase, eukaryotic type;
TIGR00699"
/db_xref="CDD:129782"
Site order(163..165,217..218,220,293,326,328..329,357)
/site_type="active"
/note="inhibitor-cofactor binding pocket [active]"
/db_xref="CDD:99735"
Site order(164..165,217..218,293,326,329,357)
/site_type="other"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]"
/db_xref="CDD:99735"
Site 252
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
Site 279
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
Site 318
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
Site 357
/site_type="active"
/note="catalytic residue [active]"
/db_xref="CDD:99735"
Site 413
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
Site 452
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
Site 470
/site_type="acetylation"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P61922; propagated from
UniProtKB/Swiss-Prot (P50554.3)"
CDS 1..500
/gene="Abat"
/gene_synonym="beta-AlaAT; Gabat"
/coded_by="NM_031003.2:102..1604"
/db_xref="GeneID:81632"
/db_xref="RGD:620948"
ORIGIN
1 mafllttrrl vcssqknlhl ftpgsryisq aaakvdfefd ydgplmktev pgprsqelmk
61 qlntiqnaea vhffcnyees rgnylvdvdg nrmldlysqi ssvpigynhp alaklvqqpq
121 nastfinrpa lgilppenfv dklreslmsv apkgmcqlit macgscsnen afktifmwyr
181 skergqrgfs keeletcmvn qspgcpdysi lsfmgafhgr tmgclatths kaihkidips
241 fdwpiapfpr lkypleefvt dnqqeearcl eevedlivky rkkkrtvagi ivepiqsegg
301 dnhasddffr klrdiarkhg caflvdevqt gggctgkfwa hehwglddpa dvmsfskkmm
361 tggffhkeef rpsapyrifn twlgdpsknl llaeviniik redllnnvah agktlltgll
421 dlqaqypqfv srvrgrgtfc sfdtpdkair nkliliarnk gvvlggcgdk sirfrptlvf
481 rdhhahlfln ifsgiladfk
//
