GenomeNet

Database: RefSeq
Entry: NP_740752
LinkDB: NP_740752
Original site: NP_740752 
LOCUS       NP_740752                426 aa            linear   PRI 05-FEB-2018
DEFINITION  small conductance calcium-activated potassium channel protein 3
            isoform b [Homo sapiens].
ACCESSION   NP_740752
VERSION     NP_740752.1
DBSOURCE    REFSEQ: accession NM_170782.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Gueguinou M, Crottes D, Chantome A, Rapetti-Mauss R,
            Potier-Cartereau M, Clarysse L, Girault A, Fourbon Y, Jezequel P,
            Guerin-Charbonnel C, Fromont G, Martin P, Pellissier B, Schiappa R,
            Chamorey E, Mignen O, Uguen A, Borgese F, Vandier C and Soriani O.
  TITLE     The SigmaR1 chaperone drives breast and colorectal cancer cell
            migration by tuning SK3-dependent Ca(2+) homeostasis
  JOURNAL   Oncogene 36 (25), 3640-3647 (2017)
   PUBMED   28114279
  REMARK    GeneRIF: Analyses of tissue microarray from colorectal cancer
            patients showed higher SigmaR1 expression levels in cancer samples
            and a correlation with tumor grade. Moreover, the exploration of a
            cohort of 4937 breast cancer patients indicated that high
            expression of SigmaR1 and Orai1 channels was significantly
            correlated to a lower overall survival
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Yang M, Camara AKS, Aldakkak M, Kwok WM and Stowe DF.
  TITLE     Identity and function of a cardiac mitochondrial small conductance
            Ca(2+)-activated K(+) channel splice variant
  JOURNAL   Biochim. Biophys. Acta 1858 (6), 442-458 (2017)
   PUBMED   28342809
  REMARK    GeneRIF: A splice variant SK3.2 was found in ventricular myocyte
            mitochondria and its mRNA expression was studied.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Gueguinou M, Harnois T, Crottes D, Uguen A, Deliot N, Gambade A,
            Chantome A, Haelters JP, Jaffres PA, Jourdan ML, Weber G, Soriani
            O, Bougnoux P, Mignen O, Bourmeyster N, Constantin B, Lecomte T,
            Vandier C and Potier-Cartereau M.
  TITLE     SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell
            migration: a novel opportunity to modulate anti-EGFR mAb action by
            the alkyl-lipid Ohmline
  JOURNAL   Oncotarget 7 (24), 36168-36184 (2016)
   PUBMED   27102434
  REMARK    GeneRIF: Data indicate that the inhibition of the Store Operated
            Calcium Entry (SOCE)-dependent colon cancer cell migration through
            SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a
            strategy to modulate Anti-EGFR mAb action in metastatic colorectal
            cancer (mCRC).
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Koot BG, Alders M, Verheij J, Beuers U and Cobben JM.
  TITLE     A de novo mutation in KCNN3 associated with autosomal dominant
            idiopathic non-cirrhotic portal hypertension
  JOURNAL   J. Hepatol. 64 (4), 974-977 (2016)
   PUBMED   26658685
  REMARK    GeneRIF: KCNN3 gene encodes small conductance calcium-activated
            potassium (SK) channel 3
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Ortega A, Tarazon E, Rosello-Lleti E, Gil-Cayuela C, Lago F,
            Gonzalez-Juanatey JR, Cinca J, Jorge E, Martinez-Dolz L, Portoles M
            and Rivera M.
  TITLE     Patients with Dilated Cardiomyopathy and Sustained Monomorphic
            Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes
            and CACNG8-Linked Left Ventricular Dysfunction
  JOURNAL   PLoS ONE 10 (12), e0145518 (2015)
   PUBMED   26710323
  REMARK    GeneRIF: Patients with Dilated Cardiomyopathy and Sustained
            Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and
            KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn
            F, Grissmer S and Morris-Rosendahl DJ.
  TITLE     An apamin- and scyllatoxin-insensitive isoform of the human SK3
            channel
  JOURNAL   Mol. Pharmacol. 65 (3), 788-801 (2004)
   PUBMED   14978258
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman
            R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy
            KG, Gargus JJ, Gutman GA and Navon R.
  TITLE     hKCa3/KCNN3 potassium channel gene: association of longer CAG
            repeats with schizophrenia in Israeli Ashkenazi Jews, expression in
            human tissues and localization to chromosome 1q21
  JOURNAL   Mol. Psychiatry 4 (3), 254-260 (1999)
   PUBMED   10395215
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH,
            Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ
            and Gargus JJ.
  TITLE     Isolation of a novel potassium channel gene hSKCa3 containing a
            polymorphic CAG repeat: a candidate for schizophrenia and bipolar
            disorder?
  JOURNAL   Mol. Psychiatry 3 (1), 32-37 (1998)
   PUBMED   9491810
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Imbert G, Saudou F, Yvert G, Devys D, Trottier Y, Garnier JM, Weber
            C, Mandel JL, Cancel G, Abbas N, Durr A, Didierjean O, Stevanin G,
            Agid Y and Brice A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat. Genet. 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J
            and Adelman JP.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA284005.1, AL390204.11,
            BC042147.1, AL606500.8 and AW135188.1.
            
            Summary: Action potentials in vertebrate neurons are followed by an
            afterhyperpolarization (AHP) that may persist for several seconds
            and may have profound consequences for the firing pattern of the
            neuron. Each component of the AHP is kinetically distinct and is
            mediated by different calcium-activated potassium channels. This
            gene belongs to the KCNN family of potassium channels. It encodes
            an integral membrane protein that forms a voltage-independent
            calcium-activated channel, which is thought to regulate neuronal
            excitability by contributing to the slow component of synaptic AHP.
            This gene contains two CAG repeat regions in the coding sequence.
            It was thought that expansion of one or both of these repeats could
            lead to an increased susceptibility to schizophrenia or bipolar
            disorder, but studies indicate that this is probably not the case.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon compared to variant 1, resulting in translation
            initiation from a different start codon, and a shorter isoform (b)
            with a distinct N-terminus compared to isoform a. This isoform
            lacks the two CAG repeat regions.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.2523.1,
                                           SRR1163658.203248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     Protein         1..426
                     /product="small conductance calcium-activated potassium
                     channel protein 3 isoform b"
                     /note="SKCa 3; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3; small
                     conductance calcium-activated potassium channel 3;
                     potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 3"
                     /calculated_mol_wt=47920
     variation       3
                     /replace="k"
                     /db_xref="dbSNP:949587411"
     variation       4
                     /replace="h"
                     /db_xref="dbSNP:139272077"
     variation       4
                     /replace="s"
                     /db_xref="dbSNP:771451565"
     variation       5
                     /replace="v"
                     /db_xref="dbSNP:541371924"
     Region          <6..75
                     /region_name="SK_channel"
                     /note="Calcium-activated SK potassium channel; pfam03530"
                     /db_xref="CDD:308894"
     variation       7
                     /replace="d"
                     /db_xref="dbSNP:748029142"
     variation       10
                     /replace="l"
                     /db_xref="dbSNP:142476638"
     variation       11
                     /replace="l"
                     /db_xref="dbSNP:754945314"
     variation       11
                     /replace="s"
                     /db_xref="dbSNP:750426969"
     variation       13
                     /replace="v"
                     /db_xref="dbSNP:765321692"
     variation       14
                     /replace="l"
                     /db_xref="dbSNP:369164690"
     variation       16
                     /replace="y"
                     /db_xref="dbSNP:757374968"
     variation       23
                     /replace="i"
                     /db_xref="dbSNP:918297653"
     variation       30
                     /replace="i"
                     /db_xref="dbSNP:754028439"
     variation       31
                     /replace="t"
                     /db_xref="dbSNP:764366056"
     variation       34
                     /replace="i"
                     /db_xref="dbSNP:760891294"
     variation       35
                     /replace="c"
                     /db_xref="dbSNP:775927958"
     variation       35
                     /replace="h"
                     /db_xref="dbSNP:760112555"
     variation       37
                     /replace="v"
                     /db_xref="dbSNP:775049811"
     variation       39
                     /replace="l"
                     /db_xref="dbSNP:767904708"
     variation       40
                     /replace="f"
                     /db_xref="dbSNP:140455860"
     variation       42
                     /replace="i"
                     /db_xref="dbSNP:752112611"
     variation       44
                     /replace="n"
                     /db_xref="dbSNP:1131820"
     variation       44
                     /replace="s"
                     /db_xref="dbSNP:767055276"
     variation       45
                     /replace="s"
                     /db_xref="dbSNP:772849147"
     variation       46
                     /replace="a"
                     /db_xref="dbSNP:540117403"
     variation       50
                     /replace="w"
                     /db_xref="dbSNP:769288919"
     variation       54
                     /replace="g"
                     /db_xref="dbSNP:751983692"
     variation       54
                     /replace="s"
                     /db_xref="dbSNP:761545559"
     variation       55
                     /replace="y"
                     /db_xref="dbSNP:913636248"
     variation       56
                     /replace="k"
                     /db_xref="dbSNP:776194606"
     variation       58
                     /replace="n"
                     /db_xref="dbSNP:768464858"
     variation       59
                     /replace="l"
                     /db_xref="dbSNP:1051614"
     variation       60
                     /replace="c"
                     /db_xref="dbSNP:772001209"
     variation       66
                     /replace="l"
                     /db_xref="dbSNP:1034183876"
     variation       68
                     /replace="c"
                     /db_xref="dbSNP:144038732"
     variation       69
                     /replace="t"
                     /db_xref="dbSNP:777932235"
     variation       70
                     /replace="v"
                     /db_xref="dbSNP:756198528"
     variation       75
                     /replace="g"
                     /db_xref="dbSNP:371681362"
     variation       76
                     /replace="k"
                     /db_xref="dbSNP:76610518"
     variation       82
                     /replace="m"
                     /db_xref="dbSNP:766922504"
     variation       82
                     /replace="t"
                     /db_xref="dbSNP:749900768"
     variation       83
                     /replace="a"
                     /db_xref="dbSNP:1051615"
     variation       84
                     /replace="h"
                     /db_xref="dbSNP:764779145"
     variation       85
                     /replace="l"
                     /db_xref="dbSNP:761267826"
     variation       86
                     /replace="a"
                     /db_xref="dbSNP:776340934"
     variation       87
                     /replace="y"
                     /db_xref="dbSNP:979389317"
     variation       89
                     /replace="y"
                     /db_xref="dbSNP:141600491"
     variation       91
                     /replace="t"
                     /db_xref="dbSNP:760404240"
     variation       92
                     /replace="s"
                     /db_xref="dbSNP:575280266"
     variation       92
                     /replace="y"
                     /db_xref="dbSNP:775295714"
     variation       93
                     /replace="q"
                     /db_xref="dbSNP:771961515"
     variation       93
                     /replace="w"
                     /db_xref="dbSNP:557073337"
     variation       94
                     /replace="a"
                     /db_xref="dbSNP:748238359"
     variation       94
                     /replace="v"
                     /db_xref="dbSNP:368720064"
     variation       96
                     /replace="a"
                     /db_xref="dbSNP:755251545"
     variation       96
                     /replace="t"
                     /db_xref="dbSNP:781422166"
     variation       97
                     /replace="n"
                     /db_xref="dbSNP:267598058"
     variation       99
                     /replace="d"
                     /db_xref="dbSNP:780585604"
     variation       99
                     /replace="h"
                     /db_xref="dbSNP:375440538"
     variation       101
                     /replace="v"
                     /db_xref="dbSNP:1026329597"
     variation       102
                     /replace="l"
                     /db_xref="dbSNP:372161618"
     variation       109
                     /replace="c"
                     /db_xref="dbSNP:750909377"
     variation       109
                     /replace="r"
                     /db_xref="dbSNP:765730337"
     variation       110
                     /replace="l"
                     /db_xref="dbSNP:756777418"
     variation       115
                     /replace="*"
                     /db_xref="dbSNP:753301038"
     variation       117
                     /replace="i"
                     /db_xref="dbSNP:75503830"
     variation       122
                     /replace="q"
                     /db_xref="dbSNP:763697141"
     variation       122
                     /replace="r"
                     /db_xref="dbSNP:760343159"
     variation       124
                     /replace="f"
                     /db_xref="dbSNP:368437227"
     variation       125
                     /replace="t"
                     /db_xref="dbSNP:146684021"
     variation       128
                     /replace="s"
                     /db_xref="dbSNP:2271117"
     variation       130
                     /replace="r"
                     /db_xref="dbSNP:759396427"
     variation       132
                     /replace="i"
                     /db_xref="dbSNP:374269558"
     variation       133
                     /replace="r"
                     /db_xref="dbSNP:770791170"
     variation       138
                     /replace="i"
                     /db_xref="dbSNP:748196476"
     variation       143
                     /replace="h"
                     /db_xref="dbSNP:777143484"
     variation       148
                     /replace="t"
                     /db_xref="dbSNP:370594487"
     variation       151
                     /replace="t"
                     /db_xref="dbSNP:963507754"
     variation       153
                     /replace="c"
                     /db_xref="dbSNP:559302379"
     variation       158
                     /replace="l"
                     /db_xref="dbSNP:534181337"
     variation       159
                     /replace="l"
                     /db_xref="dbSNP:367863664"
     variation       161
                     /replace="c"
                     /db_xref="dbSNP:182790998"
     variation       162
                     /replace="s"
                     /db_xref="dbSNP:1039861886"
     Region          163..242
                     /region_name="Ion_trans_2"
                     /note="Ion channel; pfam07885"
                     /db_xref="CDD:311712"
     variation       163
                     /replace="i"
                     /db_xref="dbSNP:138364260"
     variation       165
                     /replace="l"
                     /db_xref="dbSNP:746274298"
     variation       165
                     /replace="v"
                     /db_xref="dbSNP:758828575"
     variation       168
                     /replace="t"
                     /db_xref="dbSNP:757709658"
     variation       168
                     /replace="v"
                     /db_xref="dbSNP:779417955"
     variation       171
                     /replace="*"
                     /db_xref="dbSNP:753340296"
     variation       172
                     /replace="t"
                     /db_xref="dbSNP:763573215"
     variation       173
                     /replace="i"
                     /db_xref="dbSNP:148925371"
     variation       178
                     /replace="r"
                     /db_xref="dbSNP:763234530"
     variation       179
                     /replace="d"
                     /db_xref="dbSNP:773593953"
     variation       184
                     /replace="d"
                     /db_xref="dbSNP:576034957"
     variation       187
                     /replace="g"
                     /db_xref="dbSNP:748636403"
     variation       187
                     /replace="s"
                     /db_xref="dbSNP:777239113"
     variation       197
                     /replace="f"
                     /db_xref="dbSNP:1009320885"
     variation       197
                     /replace="s"
                     /db_xref="dbSNP:768050294"
     variation       202
                     /replace="f"
                     /db_xref="dbSNP:866256648"
     variation       205
                     /replace="y"
                     /db_xref="dbSNP:746589982"
     variation       207
                     /replace="d"
                     /db_xref="dbSNP:779516843"
     variation       208
                     /replace="i"
                     /db_xref="dbSNP:890496198"
     variation       209
                     /replace="v"
                     /db_xref="dbSNP:932772948"
     variation       210
                     /replace="p"
                     /db_xref="dbSNP:557553959"
     variation       210
                     /replace="s"
                     /db_xref="dbSNP:758076087"
     variation       213
                     /replace="h"
                     /db_xref="dbSNP:778873040"
     variation       218
                     /replace="i"
                     /db_xref="dbSNP:757157532"
     variation       223
                     /replace="g"
                     /db_xref="dbSNP:545239721"
     variation       225
                     /replace="t"
                     /db_xref="dbSNP:200867139"
     variation       235
                     /replace="a"
                     /db_xref="dbSNP:766456980"
     variation       236
                     /replace="a"
                     /db_xref="dbSNP:112703022"
     variation       238
                     /replace="v"
                     /db_xref="dbSNP:758516858"
     variation       240
                     /replace="k"
                     /db_xref="dbSNP:750643072"
     variation       245
                     /replace="k"
                     /db_xref="dbSNP:762109698"
     variation       245
                     /replace="t"
                     /db_xref="dbSNP:765504126"
     variation       246
                     /replace="a"
                     /db_xref="dbSNP:777061224"
     variation       248
                     /replace="m"
                     /db_xref="dbSNP:764469884"
     variation       249
                     /replace="h"
                     /db_xref="dbSNP:761267551"
     variation       254
                     /replace="l"
                     /db_xref="dbSNP:775910318"
     Region          256..328
                     /region_name="CaMBD"
                     /note="Calmodulin binding domain; pfam02888"
                     /db_xref="CDD:308502"
     variation       262
                     /replace="q"
                     /db_xref="dbSNP:935918876"
     variation       262
                     /replace="r"
                     /db_xref="dbSNP:372547701"
     variation       263
                     /replace="v"
                     /db_xref="dbSNP:779042876"
     variation       267
                     /replace="a"
                     /db_xref="dbSNP:757503744"
     variation       269
                     /replace="n"
                     /db_xref="dbSNP:754103274"
     variation       274
                     /replace="t"
                     /db_xref="dbSNP:572788586"
     variation       284
                     /replace="l"
                     /db_xref="dbSNP:560866177"
     variation       287
                     /replace="t"
                     /db_xref="dbSNP:952407124"
     variation       288
                     /replace="d"
                     /db_xref="dbSNP:768149702"
     variation       289
                     /replace="q"
                     /db_xref="dbSNP:759048436"
     Region          290..368
                     /region_name="Prefoldin"
                     /note="Prefoldin is a hexameric molecular chaperone
                     complex, found in both eukaryotes and archaea, that binds
                     and stabilizes newly synthesized polypeptides allowing
                     them to fold correctly. The complex contains two alpha and
                     four beta subunits, the two subunits...; cl09111"
                     /db_xref="CDD:324325"
     variation       292
                     /replace="l"
                     /db_xref="dbSNP:774027041"
     variation       299
                     /replace="f"
                     /db_xref="dbSNP:770655498"
     variation       300
                     /replace="l"
                     /db_xref="dbSNP:145724994"
     variation       306
                     /replace="l"
                     /db_xref="dbSNP:41270947"
     variation       308
                     /replace="s"
                     /db_xref="dbSNP:150313898"
     variation       309
                     /replace="i"
                     /db_xref="dbSNP:371805423"
     variation       309
                     /replace="v"
                     /db_xref="dbSNP:764812946"
     variation       310
                     /replace="r"
                     /db_xref="dbSNP:201207460"
     variation       317
                     /replace="n"
                     /db_xref="dbSNP:776442774"
     variation       319
                     /replace="e"
                     /db_xref="dbSNP:768533962"
     variation       321
                     /replace="n"
                     /db_xref="dbSNP:746927647"
     variation       333
                     /replace="i"
                     /db_xref="dbSNP:950244144"
     variation       333
                     /replace="t"
                     /db_xref="dbSNP:757871783"
     variation       336
                     /replace="l"
                     /db_xref="dbSNP:749908433"
     variation       341
                     /replace="s"
                     /db_xref="dbSNP:927916560"
     variation       343
                     /replace="r"
                     /db_xref="dbSNP:764907068"
     variation       345
                     /replace="v"
                     /db_xref="dbSNP:761396508"
     variation       347
                     /replace="l"
                     /db_xref="dbSNP:917524524"
     variation       350
                     /replace="e"
                     /db_xref="dbSNP:776316771"
     variation       355
                     /replace="e"
                     /db_xref="dbSNP:991708080"
     variation       356
                     /replace="l"
                     /db_xref="dbSNP:763846307"
     variation       358
                     /replace="l"
                     /db_xref="dbSNP:760531110"
     variation       361
                     /replace="h"
                     /db_xref="dbSNP:61811431"
     variation       362
                     /replace="t"
                     /db_xref="dbSNP:562479403"
     variation       363
                     /replace="s"
                     /db_xref="dbSNP:543914524"
     variation       366
                     /replace="t"
                     /db_xref="dbSNP:201738401"
     variation       367
                     /replace="p"
                     /db_xref="dbSNP:773185644"
     variation       369
                     /replace="p"
                     /db_xref="dbSNP:748347248"
     variation       371
                     /replace="l"
                     /db_xref="dbSNP:564861358"
     variation       372
                     /replace="i"
                     /db_xref="dbSNP:374819006"
     variation       373
                     /replace="a"
                     /db_xref="dbSNP:747394806"
     variation       373
                     /replace="v"
                     /db_xref="dbSNP:371429880"
     variation       382
                     /replace="-"
                     /db_xref="dbSNP:149440400"
     variation       382
                     /replace="q"
                     /db_xref="dbSNP:762020489"
     variation       384
                     /replace="l"
                     /db_xref="dbSNP:867367933"
     variation       385
                     /replace="s"
                     /db_xref="dbSNP:540307843"
     variation       387
                     /replace="i"
                     /db_xref="dbSNP:758862833"
     variation       390
                     /replace="t"
                     /db_xref="dbSNP:756664099"
     variation       391
                     /replace="q"
                     /db_xref="dbSNP:377688678"
     variation       392
                     /replace="r"
                     /db_xref="dbSNP:374192381"
     variation       396
                     /replace="s"
                     /db_xref="dbSNP:978522766"
     variation       396
                     /replace="v"
                     /db_xref="dbSNP:756801201"
     variation       397
                     /replace="v"
                     /db_xref="dbSNP:914885726"
     variation       400
                     /replace="s"
                     /db_xref="dbSNP:753486219"
     variation       403
                     /replace="l"
                     /db_xref="dbSNP:763748485"
     variation       403
                     /replace="s"
                     /db_xref="dbSNP:967553480"
     variation       404
                     /replace="v"
                     /db_xref="dbSNP:200865416"
     variation       405
                     /replace="s"
                     /db_xref="dbSNP:752464816"
     variation       409
                     /replace="t"
                     /db_xref="dbSNP:76925601"
     variation       411
                     /replace="d"
                     /db_xref="dbSNP:920992562"
     variation       411
                     /replace="f"
                     /db_xref="dbSNP:764160677"
     variation       417
                     /replace="l"
                     /db_xref="dbSNP:774384644"
     variation       418
                     /replace="t"
                     /db_xref="dbSNP:769754241"
     variation       419
                     /replace="a"
                     /db_xref="dbSNP:201808409"
     variation       419
                     /replace="l"
                     /db_xref="dbSNP:144072589"
     variation       419
                     /replace="p"
                     /db_xref="dbSNP:199920438"
     variation       420
                     /replace="n"
                     /db_xref="dbSNP:996024923"
     variation       422
                     /replace="n"
                     /db_xref="dbSNP:574750243"
     variation       424
                     /replace="s"
                     /db_xref="dbSNP:371063589"
     CDS             1..426
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3"
                     /coded_by="NM_170782.2:151..1431"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS1072.1"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
ORIGIN      
        1 merpikdsmf slalkclisl stiillglii ayhtrevqlf vidngaddwr iamtyerily
       61 islemlvcai hpipgeykff wtarlafsyt psraeadvdi ilsipmflrl yliarvmllh
      121 sklftdassr sigalnkinf ntrfvmktlm ticpgtvllv fsislwiiaa wtvrvceryh
      181 dqqdvtsnfl gamwlisitf lsigygdmvp htycgkgvcl ltgimgagct alvvavvark
      241 leltkaekhv hnfmmdtqlt kriknaaanv lretwliykh tkllkkidha kvrkhqrkfl
      301 qaihqlrsvk meqrklsdqa ntlvdlskmq nvmydlitel ndrsedlekq igsleskleh
      361 ltasfnslpl liadtlrqqq qqllsaiiea rgvsvavgtt htpisdspig vsstsfptpy
      421 tssssc
//
DBGET integrated database retrieval system