LOCUS XP_006529591 735 aa linear ROD 10-APR-2023
DEFINITION 2-5A-dependent ribonuclease isoform X1 [Mus musculus].
ACCESSION XP_006529591
VERSION XP_006529591.1
DBLINK BioProject: PRJNA169
DBSOURCE REFSEQ: accession XM_006529528.5
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT MODEL REFSEQ: This record is predicted by automated computational
analysis. This record is derived from a genomic sequence
(NC_000067.7) annotated using gene prediction method: Gnomon,
supported by mRNA and EST evidence.
Also see:
Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI RefSeq
Annotation Status :: Updated annotation
Annotation Name :: GCF_000001635.27-RS_2023_04
Annotation Pipeline :: NCBI eukaryotic genome annotation
pipeline
Annotation Software Version :: 10.1
Annotation Method :: Best-placed RefSeq; Gnomon;
RefSeqFE; cmsearch; tRNAscan-SE
Features Annotated :: Gene; mRNA; CDS; ncRNA
Annotation Date :: 04/05/2023
##Genome-Annotation-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..735
/organism="Mus musculus"
/strain="C57BL/6J"
/db_xref="taxon:10090"
/chromosome="1"
Protein 1..735
/product="2-5A-dependent ribonuclease isoform X1"
/calculated_mol_wt=83144
Region 24..55
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region <29..88
/region_name="Ank_2"
/note="Ankyrin repeats (3 copies); pfam12796"
/db_xref="CDD:432791"
Region 59..89
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Site order(60,64..65,68..70,72..73,77,80,89,91,93,97..98,
101..103,105..106,110,113,122,124,126,130..131,134..136,
138..139,143,146)
/site_type="other"
/note="oligomer interface [polypeptide binding]"
/db_xref="CDD:293786"
Region 61..>298
/region_name="Ank_2"
/note="Ankyrin repeats (3 copies); cl39094"
/db_xref="CDD:453966"
Region 91..122
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 124..154
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 167..199
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 238..270
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 272..297
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 361..585
/region_name="PKc_like"
/note="Protein Kinases, catalytic domain; cl21453"
/db_xref="CDD:451246"
Site order(370..373,377,378,389,391,417,433..436,483,487..488,
490,500..501)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:270870"
Region 588..707
/region_name="RNase_RNase-L"
/note="RNase domain (also known as the kinase extension
nuclease domain) of RNase L; cd10423"
/db_xref="CDD:199218"
Site order(588..589,592,596,669)
/site_type="other"
/note="putative ligand binding site [chemical binding]"
/db_xref="CDD:199218"
Site order(590,692,696,699..700,704)
/site_type="other"
/note="putative kinase interface [polypeptide binding]"
/db_xref="CDD:199218"
Site order(592,596,599..600,666,669..670)
/site_type="other"
/note="putative homodimer interface [polypeptide binding]"
/db_xref="CDD:199218"
CDS 1..735
/gene="Rnasel"
/gene_synonym="E230029I04Rik"
/coded_by="XM_006529528.5:764..2971"
/db_xref="GeneID:24014"
/db_xref="MGI:MGI:1098272"
ORIGIN
1 metpdyntpq ggtpsagsqr tvveddssli kavqkgdvvr vqqllekgad anacedtwgw
61 tplhnavqag rvdivnllls hgadphrrkk ngatpfiiag iqgdvkllei llscgadvne
121 cdengftafm eaaergnaea lrflfakgan vnlrrqttkd krrlkqggat almsaaekgh
181 levlrillnd mkaevdardn mgrnalirtl lnwdcenvee itsiliqhga dvnvrgergk
241 tpliaaverk htglvqmlls reginidard negktallia vdkqlkeivq lllekgadkc
301 ddlvwiarrn hdyhlvklll pyvanpdtdp pagdwsphss rwgtalkslh smtrpmigkl
361 kifihddyki agtsegavyl giydnrevav kvfrensprg ckevsclrdc gdhsnlvafy
421 greddkgcly vcvslcewtl eeflrlpree pvengedkfa hsillsifeg vqklhlhgys
481 hqdlqpqnil idskkavrla dfdqsirwmg esqmvrrdle dlgrlvlyvv mkgeipfetl
541 ktqndevllt mspdeetkdl ihclfspgen vknclvdllg hpffwtwenr yrtlrnvgne
601 sdikvrkcks dllrllqhqt lepprsfdqw tskidknvmd emnhfyekrk knpyqdtvgd
661 llkfirnige hineekkrgm keilgdpsry fqetfpdlvi yiykklkete yrkhfpqppp
721 rlsvpeavgp ggiqs
//
