LOCUS       XP_008962362             318 aa            linear   PRI 11-JUN-2023
DEFINITION  DNA-(apurinic or apyrimidinic site) endonuclease [Pan paniscus].
ACCESSION   XP_008962362
VERSION     XP_008962362.1
DBLINK      BioProject: PRJNA950461
DBSOURCE    REFSEQ: accession XM_008964114.2
KEYWORDS    RefSeq.
SOURCE      Pan paniscus (pygmy chimpanzee)
  ORGANISM  Pan paniscus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pan.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_073263) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_029289425.1-RS_2023_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/31/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Pan paniscus"
                     /db_xref="taxon:9597"
                     /chromosome="14"
                     /sex="male"
                     /cell_line="PR00251"
                     /cell_type="fibroblast"
                     /dev_stage="adult"
     Protein         1..318
                     /product="DNA-(apurinic or apyrimidinic site)
                     endonuclease"
                     /calculated_mol_wt=35438
     Region          62..316
                     /region_name="Ape1-like_AP-endo"
                     /note="Human Ape1-like subfamily of the ExoIII family
                     apurinic/apyrimidinic (AP) endonucleases; cd09087"
                     /db_xref="CDD:197321"
     Site            order(68,70..74,78,96,98,103,127..128,171,174,210,212,222,
                     224,226,229..230,266,268..270,276,278,280,282..283,309)
                     /site_type="active"
                     /db_xref="CDD:197321"
     Site            order(68,70..74,78,96,98,103,127..128,171,174,210,212,222,
                     224,226,229..230,266,268..270,276,278,280,282,309)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197321"
     Site            order(68,96,171,174,210,212,309)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197321"
     Site            order(68,96,171,210,212,283,308..309)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197321"
     Site            order(70,96,308)
                     /site_type="metal-binding"
                     /note="metal binding site A [ion binding]"
                     /db_xref="CDD:197321"
     Site            order(171,174,210,212,230,266,280,282,309)
                     /site_type="other"
                     /note="AP binding site [nucleotide binding]"
                     /db_xref="CDD:197321"
     Site            order(210,212,309)
                     /site_type="metal-binding"
                     /note="metal binding site B [ion binding]"
                     /db_xref="CDD:197321"
     CDS             1..318
                     /gene="APEX1"
                     /coded_by="XM_008964114.2:150..1106"
                     /db_xref="GeneID:100987860"
ORIGIN      
        1 mpkrgkkgav aedgdelrte peakksktaa kkndkeaage gpalyedppd qktspsgkpa
       61 tlkicswnvd glrawikkkg ldwvkeeapd ilclqetkcs enklpaelqe lpglshqyws
      121 apsdkegysg vgllsrqcpl kvsygigeee hdqegrviva efdsfvlvta yvpnagrglv
      181 rleyrqrwde afrkflkgla srkplvlcgd lnvaheeidl rnpkgnkkna gftpqerqgf
      241 gellqavpla dsfrhlypnt pyaytfwtym mnarsknvgw rldyfllshs llpalcdski
      301 rskalgsdhc pitlylal
//