LOCUS XP_749922 1165 aa linear PLN 27-FEB-2008
DEFINITION protein kinase and ribonuclease Ire1 [Aspergillus fumigatus Af293].
ACCESSION XP_749922
VERSION XP_749922.1 GI:70990146
DBSOURCE REFSEQ: accession XM_744829.1
KEYWORDS .
SOURCE Aspergillus fumigatus Af293
ORGANISM Aspergillus fumigatus Af293
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
mitosporic Trichocomaceae; Aspergillus.
REFERENCE 1 (residues 1 to 1165)
AUTHORS Nierman,W.C., Pain,A., Anderson,M.J., Wortman,J.R., Kim,H.S.,
Arroyo,J., Berriman,M., Abe,K., Archer,D.B., Bermejo,C.,
Bennett,J., Bowyer,P., Chen,D., Collins,M., Coulsen,R., Davies,R.,
Dyer,P.S., Farman,M., Fedorova,N., Fedorova,N., Feldblyum,T.V.,
Fischer,R., Fosker,N., Fraser,A., Garcia,J.L., Garcia,M.J.,
Goble,A., Goldman,G.H., Gomi,K., Griffith-Jones,S., Gwilliam,R.,
Haas,B., Haas,H., Harris,D., Horiuchi,H., Huang,J., Humphray,S.,
Jimenez,J., Keller,N., Khouri,H., Kitamoto,K., Kobayashi,T.,
Konzack,S., Kulkarni,R., Kumagai,T., Lafon,A., Latge,J.P., Li,W.,
Lord,A., Lu,C., Majoros,W.H., May,G.S., Miller,B.L., Mohamoud,Y.,
Molina,M., Monod,M., Mouyna,I., Mulligan,S., Murphy,L., O'Neil,S.,
Paulsen,I., Penalva,M.A., Pertea,M., Price,C., Pritchard,B.L.,
Quail,M.A., Rabbinowitsch,E., Rawlins,N., Rajandream,M.A.,
Reichard,U., Renauld,H., Robson,G.D., Rodriguez de Cordoba,S.,
Rodriguez-Pena,J.M., Ronning,C.M., Rutter,S., Salzberg,S.L.,
Sanchez,M., Sanchez-Ferrero,J.C., Saunders,D., Seeger,K.,
Squares,R., Squares,S., Takeuchi,M., Tekaia,F., Turner,G., Vazquez
de Aldana,C.R., Weidman,J., White,O., Woodward,J., Yu,J.H.,
Fraser,C., Galagan,J.E., Asai,K., Machida,M., Hall,N., Barrell,B.
and Denning,D.W.
TITLE Genomic sequence of the pathogenic and allergenic filamentous
fungus Aspergillus fumigatus
JOURNAL Nature 438 (7071), 1151-1156 (2005)
PUBMED 16372009
REMARK Erratum:[Nature. 2006 Jan 26;439(7075):502. Lafton, Anne [corrected
to Lafon, Anne]]
REFERENCE 2 (residues 1 to 1165)
AUTHORS Nierman,W., Wortman,J., Pain,A., Anderson,M.J., Arroya,J., Hall,N.,
Barrell,B., Fraser,C. and Denning,D.W.
TITLE Direct Submission
JOURNAL Submitted (20-MAY-2005) The Institute for Genomic Research, 9712
Medical Center Dr, Rockville, MD 20850, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from EAL87884.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..1165
/organism="Aspergillus fumigatus Af293"
/strain="Af293"
/db_xref="taxon:330879"
/chromosome="1"
Protein 1..1165
/product="protein kinase and ribonuclease Ire1"
/EC_number="2.7.1.-"
/calculated_mol_wt=129919
Region 110..406
/region_name="Luminal_IRE1"
/note="The Luminal domain, a dimerization domain, of the
Serine/Threonine protein kinase, Inositol-requiring
protein 1; cd09769"
/db_xref="CDD:188875"
Site order(201..205,212,214..217,219..221,233,235..237,240,
270..271,279,281,296,298..300)
/site_type="other"
/note="homodimer interface [polypeptide binding]"
/db_xref="CDD:188875"
Region 716..1026
/region_name="S_TKc"
/note="Serine/Threonine protein kinases, catalytic domain;
smart00220"
/db_xref="CDD:197582"
Region 717..995
/region_name="PKc"
/note="Catalytic domain of Protein Kinases; cd00180"
/db_xref="CDD:173623"
Site order(717..721,725,737,739,766,782..785,788,790,832,834,
836..837,839,858,861,881..884)
/site_type="active"
/db_xref="CDD:173623"
Site order(717..721,725,737,739,766,782..785,788,832,834,
836..837,839,858)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:173623"
Site order(721,788,790,832,834,836,861,881..884)
/site_type="other"
/note="substrate binding site [chemical binding]"
/db_xref="CDD:173623"
Site order(857..863,881..884)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:173623"
Region 1032..1161
/region_name="RNase_Ire1"
/note="RNase domain (also known as the kinase extension
nuclease domain) of Ire1; cd10422"
/db_xref="CDD:199217"
Site order(1032,1132,1136,1139..1140,1144)
/site_type="other"
/note="kinase interface [polypeptide binding]"
/db_xref="CDD:199217"
Site order(1034,1038,1106,1124,1156,1159..1160)
/site_type="other"
/note="ligand binding site [chemical binding]"
/db_xref="CDD:199217"
Site order(1034,1038,1041..1042,1103,1106..1107,1110,
1123..1125,1155..1156,1159)
/site_type="other"
/note="homodimer interface [polypeptide binding]"
/db_xref="CDD:199217"
CDS 1..1165
/locus_tag="AFUA_1G01720"
/old_locus_tag="Afu1g01720"
/coded_by="XM_744829.1:1..3498"
/note="encoded by transcript AFUA_1G01720A;
similar to serine-threonine kinase and endoribonuclease;
transmembrane protein that initiates the unfolded protein
response signal by regulating synthesis of Hac1p through
HAC1 mRNA splicing; Ire1p (GI:6321870) [Saccharomyces
cerevisiae] similar to GB:BAB21297.1: protein
kinase/ribonuclease IRE1 beta [Homo sapiens]
GB:AAB68894.1: Ire1p: Probable protein kinase
{Saccharomyces cerevisiae;}"
/db_xref="GeneID:3507278"
ORIGIN
1 mrwrlpgart tlpasvalll lpilvapqql qehddlpstl svplsptqrs fdhhplptin
61 vksndasala tmalagpgra vrarpaqass ssaglapqlh arslqdweve dfvllatvdg
121 sihardrrtg aarwalevps spmvesiyhr anrssfdraq peddflwive psqdgnlyiy
181 spgpdaglqk lgltvkelve qtpysgtdpa vtytarkett lytvdartgn ilqvfssrgp
241 itsghgcrkv dgfdleaeec dtpsgtlvlg rveyavaiqn tetgdpictl kysewtannr
301 dmdlqsqyfr tmdqshiysm hdgvvlgfdh srmdrprytq rfsspvvrvf dvarpinves
361 peaatplvll sqplqppdpd ygslddrdar vfvdctsagg wfamseetyp lvtgrakmaq
421 cyekdylrhg qpltslptsq qrdalagvhs lngprvvrnt psisgpsple landtprelm
481 rspselalpp alrhstiirk gwdnavdifv tilllffgaf iyfnshniqe lakqkldvkn
541 iiasyaqppl stpstpvves thfkrdssps rpisnltvev tvpeeqqegd atpkpkrdrs
601 avgpdstprv kirepsrgpd sdddveeldq aaspekpkkk arrgrrggkn hrrgkkpdse
661 geskdqadrv vdqvnnlqpq srlepdlqlv rtvsndiiem dgvlqigrlr vfsdvvlghg
721 shgtvvyrgs fdgrdvavkr mlvefydias hevgllqesd dhnnviryfc reqaagflyi
781 alelcpaslq dlierpgdyp qlvqggldmp dilrqiiagv rylhslkivh rdlkpqnilv
841 amprgrtgsr slrllisdfg lckklddnqs sfrattahaa gtsgwrapel lvdddnrsai
901 qggesqhtes sepavvdpqt nrratraidi fslgcvfyyv ltrgshpfdk ngkfmreani
961 vkgnfnldel qrlgdyafea ddlirsmlsl dprkrlaplc sslafrlftd lfprpdasav
1021 lmhpffwnps drlsflcdvs dhfefeprdp psdallcles vacrvmgpem dflrllpkdf
1081 kdnlgkqrky tgskmldllr alrnkrnhyn dmpahlkahi gglpegylnf wtvrfpsllm
1141 schsvivelr ltkidrfkry ftpve
//
