KEGG   REACTION: R00074Help
Entry
R00074                      Reaction                               

Name
2-aminophenol:oxygen oxidoreductase (dimerizing)
Definition
2 2-Aminophenol + Oxygen + Acceptor <=> 2-Aminophenoxazin-3-one + 2 H2O + Reduced acceptor
Equation
Comment
multi-step reaction (see R08762+R08763)
RPair
C00001_C00007 cofac
C01987_C02161 main
C01987_C02161 main
Enzyme
Pathway
Tryptophan metabolism
Reference
1  [PMID:14298835]
NAIR PM, VINING LC.
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
Biochim. Biophys. Acta. 96 (1965) 318-27.
2  [PMID:4166439]
Subba Rao PV, Vaidyanathan CS.
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
Arch. Biochem. Biophys. 118 (1967) 388-94.
3  [PMID:16282322]
Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S.
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
J. Biol. Chem. 281 (2006) 824-33.

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