KEGG   REACTION: R00074Help
Entry
R00074                      Reaction                               

Name
2-aminophenol:oxygen oxidoreductase (dimerizing)
Definition
4 2-Aminophenol + 3 Oxygen <=> 2 2-Aminophenoxazin-3-one + 6 H2O
Equation
4 C01987 + 3 C00007 <=> 2 C02161 + 6 C00001
Comment
multi-step reaction (see R08762+R08763)
RPair
C00001_C00007 cofac
C01987_C02161 main [RC:RC00767]
C01987_C02161 main [RC:RC02319]
Enzyme
Pathway
Tryptophan metabolism
Reference
1  [PMID:14298835]
NAIR PM, VINING LC.
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
Biochim. Biophys. Acta. 96 (1965) 318-27.
2  [PMID:4166439]
Subba Rao PV, Vaidyanathan CS.
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
Arch. Biochem. Biophys. 118 (1967) 388-94.
3  [PMID:16282322]
Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S.
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
J. Biol. Chem. 281 (2006) 824-33.

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