KEGG   REACTION: R00084Help
Entry
R00084                      Reaction                               

Name
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing);
porphobilinogen ammonia-lyase (polymerizing)
Definition
4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 Ammonia
Equation
4 C00931 + C00001 <=> C01024 + 4 C00014
Comment
multi-step reaction
RPair
C00001_C01024 leave
C00931_C01024 trans
C00014_C00931 leave
C00931_C01024 trans
C00931_C01024 trans
C00931_C01024 main [RC:RC02317]
Enzyme
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
M00121  
Heme biosynthesis, glutamate => protoheme/siroheme
Orthology
K01749  
hydroxymethylbilane synthase [EC:2.5.1.61]

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