KEGG   REACTION: R00267Help
Entry
R00267                      Reaction                               

Name
Isocitrate:NADP+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
Equation
Comment
two-step reaction (see R01899+R00268)
Reaction class
RC00001  C00005_C00006
RC00114  C00026_C00311
RC02801  C00011_C00311
Enzyme
Pathway
rn00480  Glutathione metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00173  Reductive citrate cycle (Arnon-Buchanan cycle)
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19632

KEGG   REACTION: R01899Help
Entry
R01899                      Reaction                               

Name
Isocitrate:NADP+ oxidoreductase
Definition
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
Equation
Comment
the first step of two-step reaction (see R00267, R01899+R00268)
subsequently R00268
Reaction class
RC00001  C00005_C00006
RC00084  C00311_C05379
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 25591

KEGG   REACTION: R00268Help
Entry
R00268                      Reaction                               

Name
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Definition
Oxalosuccinate <=> 2-Oxoglutarate + CO2
Equation
Comment
the second step of two-step reaction (see R00267, R01899+R00268)
following after R01899
Reaction class
RC00626  C00026_C05379
Enzyme
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00740  Methylaspartate cycle
Orthology
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Other DBs
RHEA: 19384

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