KEGG   REACTION: R00428Help
Entry
R00428                      Reaction                               

Name
GTP 8,9-hydrolase
Definition
GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate
Equation
Comment
the first step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
subsequently R05046
Reaction class
C00044_C05922
Enzyme
Pathway
Folate biosynthesis
Metabolic pathways
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF
M00841  
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  
Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  
L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Orthology
K01495  
GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  
GTP cyclohydrolase IB [EC:3.5.4.16]

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