KEGG   REACTION: R00621
Entry
R00621                      Reaction                               
Definition
2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2
Equation
C00026 + C00068 <=> C05381 + C00011
Comment
2-oxoglutarate dehydrogenase complex: 2-oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
subsequently R03316
Reaction class
RC00027  C00068_C05381
RC02743  C00026_C05381
Enzyme
1.2.4.2
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00785  Lipoic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2
     R00621  2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (7944)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (7942)   
All databases (7958)   

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KEGG   REACTION: R03316
Entry
R03316                      Reaction                               
Definition
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate
Equation
C05381 + C15972 <=> C16254 + C00068
Comment
2-oxoglutarate dehydrogenase complex: 2-oxoglutarate dehydrogenase (see R01700)
TPP-dependent enzymatic reaction (see R00621+R03316)
following after R00621
Reaction class
RC00027  C00068_C05381
RC00627  C15972_C16254
RC02883  C05381_C16254
Enzyme
1.2.4.2
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00785  Lipoic acid metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2
     R03316  3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + Thiamin diphosphate
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (7944)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (7942)   
All databases (7959)   

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