KEGG   REACTION: R00918Help
Entry
R00918                      Reaction                               
Name
propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing);
propanoyl-CoA:(2S)-methylmalonyl-CoA 2-C-acyltransferase (decarboxylating, oxoacyl-reducing and cyclizing)
Definition
Propanoyl-CoA + 6 (S)-Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 6-Deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
Equation
C00100 + 6 C00683 + 6 C00005 + 6 C00080 <=> C03240 + 7 C00010 + 6 C00011 + C00001 + 6 C00006
Comment
EryA MegA
multi-step reaction
RPair
C00005_C00006 cofac
C00010_C00100 main
C00010_C00683 main
C00100_C03240 main
C00683_C03240 main
C00011_C00683 leave
C00683_C03240 main
C00683_C03240 main
C00683_C03240 main
C00683_C03240 main
C00683_C03240 main
C00001_C00683 leave
Enzyme
Pathway
Biosynthesis of 12-, 14- and 16-membered macrolides
Biosynthesis of secondary metabolites
Orthology
K10817  
erythronolide synthase [EC:2.3.1.94]
Reference
1  [PMID:11752428]
Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14808-13.
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