KEGG   REACTION: R00936Help
Entry
R00936                      Reaction                               

Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+
Equation
Comment
NADPH (see R00939)
Reaction class
RC00001  C00003_C00004
RC00109  C00101_C00415
Enzyme
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13938  dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]

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