KEGG REACTION: R06481

REACTION: R06481

Entry

R06481 Reaction

Definition

2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+

Equation

C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11977 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006

Comment

type I polyketide synthase, AveA1-4

RPair

RP00001	C00005_C00006 cofac
RP00051	C00010_C00083 main
RP00320	C00010_C01033 main
RP05694	C00011_C00083 leave
RP05961	C00010_C02557 main
RP06096	C00011_C02557 leave
RP08515	C00001_C02557 leave
RP08518	C00001_C00083 leave
RP11265	C01033_C11977 main
RP11414	C02557_C11977 main
RP13977	C02557_C11977 main
RP13978	C02557_C11977 main
RP13979	C02557_C11977 main
RP13980	C02557_C11977 main
RP13981	C00083_C11977 main
RP13982	C00083_C11977 main
RP13983	C00083_C11977 main
RP13984	C00083_C11977 main
RP13985	C00083_C11977 main
RP13986	C00083_C11977 main
RP13987	C00083_C11977 main

Pathway

rn00522	Biosynthesis of 12-, 14- and 16-membered macrolides
rn01110	Biosynthesis of secondary metabolites

Orthology

K14371

type I polyketide synthase AVES

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (34)   
   KEGG RPAIR (21)   
   KEGG RCLASS (13)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (54)   

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