KEGG   REACTION: R06778Help
Entry
R06778                      Reaction                               

Definition
5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate + 3-Amino-4,7-dihydroxycoumarin + ATP + 2 S-Adenosyl-L-methionine <=> Coumermic acid + AMP + Diphosphate + 2 S-Adenosyl-L-homocysteine
Equation
Comment
multi-step reaction
ligase, CouL
methyltransferase, CouO
RPair
C00019_C00021 main [RC:RC00003]
C00002_C00020 ligase
C00002_C00013 ligase
C12479_C20637 main [RC:RC03149]
C12468_C12479 main [RC:RC03150]
C00019_C12479 trans
Pathway
Novobiocin biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12725  
coumermycin A biosynthesis protein CouL
K17627  
coumermycin A biosynthesis protein CouO

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