KEGG   REACTION: R07601Help
Entry
R07601                      Reaction                               

Definition
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Equation
Comment
Oxo-acid dehydrogenase complexes (see R01702), subsequently R07602
RPair
C00011_C00233 leave
C00068_C15974 main [RC:RC00027]
C00233_C15974 main [RC:RC02743]
Enzyme
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Module
M00036  
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Orthology
K00166  
2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
K00167  
2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
K11381  
2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

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