KEGG   REACTION: R07603Help
Entry
R07603                      Reaction                               

Definition
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Equation
Comment
Oxo-acid dehydrogenase complexes (see R04225), subsequently R07604
RPair
C00011_C00671 leave
C00068_C15978 main [RC:RC00027]
C00671_C15978 main [RC:RC02949]
Enzyme
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00166  
2-oxoisovalerate dehydrogenase E1 component, alpha subunit [EC:1.2.4.4]
K00167  
2-oxoisovalerate dehydrogenase E1 component, beta subunit [EC:1.2.4.4]
K11381  
2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

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