KEGG   REACTION: R08257Help
Entry
R08257                      Reaction                               

Definition
Irinotecan + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> NPC + Glutaral + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C16641 + 2 C03024 + 2 C00007 <=> C16543 + C12518 + 2 C03161 + 2 C00001
Comment
CYP3A4
Reaction class
C16543_C16641
C12518_C16641
Enzyme
1.14.13.-
Pathway
Drug metabolism - other enzymes
Orthology
K17689  
cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]

DBGET integrated database retrieval system