KEGG   REACTION: R10880Help
Entry
R10880                      Reaction                               

Definition
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
Equation
Comment
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
Reaction class
C00062_C20910
C12323_C20910
C12323_C17355
C12323_C17355
C00065_C17355
Pathway
Monobactam biosynthesis
Biosynthesis of antibiotics
Module
M00736  
Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Orthology
K05375  
MbtH protein
K19102  
nocardicin nonribosomal peptide synthetase NocA
K19103  
nocardicin nonribosomal peptide synthetase NocB
Reference
1  [PMID:25624104]
Gaudelli NM, Long DH, Townsend CA.
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
Nature.  (2015) .
2  [PMID:24531841]
Gaudelli NM, Townsend CA.
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis.
Nat. Chem. Biol. 10 (2014) 251-8.

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