KEGG   Rattus norvegicus (rat): 116590Help
Entry
116590            CDS       T01003                                 

Gene name
Mapk1, Erk2
Definition
mitogen activated protein kinase 1 (EC:2.7.11.24)
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    116590 (Mapk1)
   04015 Rap1 signaling pathway
    116590 (Mapk1)
   04010 MAPK signaling pathway
    116590 (Mapk1)
   04012 ErbB signaling pathway
    116590 (Mapk1)
   04350 TGF-beta signaling pathway
    116590 (Mapk1)
   04370 VEGF signaling pathway
    116590 (Mapk1)
   04668 TNF signaling pathway
    116590 (Mapk1)
   04066 HIF-1 signaling pathway
    116590 (Mapk1)
   04068 FoxO signaling pathway
    116590 (Mapk1)
   04024 cAMP signaling pathway
    116590 (Mapk1)
   04022 cGMP - PKG signaling pathway
    116590 (Mapk1)
   04151 PI3K-Akt signaling pathway
    116590 (Mapk1)
   04150 mTOR signaling pathway
    116590 (Mapk1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    116590 (Mapk1)
  Cell growth and death
   04114 Oocyte meiosis
    116590 (Mapk1)
  Cellular commiunity
   04510 Focal adhesion
    116590 (Mapk1)
   04520 Adherens junction
    116590 (Mapk1)
   04540 Gap junction
    116590 (Mapk1)
   04550 Signaling pathways regulating pluripotency of stem cells
    116590 (Mapk1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    116590 (Mapk1)
   04620 Toll-like receptor signaling pathway
    116590 (Mapk1)
   04621 NOD-like receptor signaling pathway
    116590 (Mapk1)
   04650 Natural killer cell mediated cytotoxicity
    116590 (Mapk1)
   04660 T cell receptor signaling pathway
    116590 (Mapk1)
   04662 B cell receptor signaling pathway
    116590 (Mapk1)
   04664 Fc epsilon RI signaling pathway
    116590 (Mapk1)
   04666 Fc gamma R-mediated phagocytosis
    116590 (Mapk1)
   04062 Chemokine signaling pathway
    116590 (Mapk1)
  Endocrine system
   04910 Insulin signaling pathway
    116590 (Mapk1)
   04912 GnRH signaling pathway
    116590 (Mapk1)
   04915 Estrogen signaling pathway
    116590 (Mapk1)
   04914 Progesterone-mediated oocyte maturation
    116590 (Mapk1)
   04917 Prolactin signaling pathway
    116590 (Mapk1)
   04921 Oxytocin signaling pathway
    116590 (Mapk1)
   04919 Thyroid hormone signaling pathway
    116590 (Mapk1)
   04916 Melanogenesis
    116590 (Mapk1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    116590 (Mapk1)
   04270 Vascular smooth muscle contraction
    116590 (Mapk1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    116590 (Mapk1)
  Nervous system
   04724 Glutamatergic synapse
    116590 (Mapk1)
   04725 Cholinergic synapse
    116590 (Mapk1)
   04726 Serotonergic synapse
    116590 (Mapk1)
   04720 Long-term potentiation
    116590 (Mapk1)
   04730 Long-term depression
    116590 (Mapk1)
   04723 Retrograde endocannabinoid signaling
    116590 (Mapk1)
   04722 Neurotrophin signaling pathway
    116590 (Mapk1)
  Development
   04320 Dorso-ventral axis formation
    116590 (Mapk1)
   04360 Axon guidance
    116590 (Mapk1)
   04380 Osteoclast differentiation
    116590 (Mapk1)
  Environmental adaptation
   04713 Circadian entrainment
    116590 (Mapk1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    116590 (Mapk1)
   05205 Proteoglycans in cancer
    116590 (Mapk1)
   05203 Viral carcinogenesis
    116590 (Mapk1)
   05210 Colorectal cancer
    116590 (Mapk1)
   05212 Pancreatic cancer
    116590 (Mapk1)
   05214 Glioma
    116590 (Mapk1)
   05216 Thyroid cancer
    116590 (Mapk1)
   05221 Acute myeloid leukemia
    116590 (Mapk1)
   05220 Chronic myeloid leukemia
    116590 (Mapk1)
   05218 Melanoma
    116590 (Mapk1)
   05211 Renal cell carcinoma
    116590 (Mapk1)
   05219 Bladder cancer
    116590 (Mapk1)
   05215 Prostate cancer
    116590 (Mapk1)
   05213 Endometrial cancer
    116590 (Mapk1)
   05223 Non-small cell lung cancer
    116590 (Mapk1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    116590 (Mapk1)
   05020 Prion diseases
    116590 (Mapk1)
  Substance dependence
   05034 Alcoholism
    116590 (Mapk1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    116590 (Mapk1)
  Infectious diseases
   05132 Salmonella infection
    116590 (Mapk1)
   05133 Pertussis
    116590 (Mapk1)
   05152 Tuberculosis
    116590 (Mapk1)
   05164 Influenza A
    116590 (Mapk1)
   05161 Hepatitis B
    116590 (Mapk1)
   05160 Hepatitis C
    116590 (Mapk1)
   05145 Toxoplasmosis
    116590 (Mapk1)
   05140 Leishmaniasis
    116590 (Mapk1)
   05142 Chagas disease (American trypanosomiasis)
    116590 (Mapk1)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     116590 (Mapk1)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   116590 (Mapk1)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   116590 (Mapk1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
11q23
AA seq 358 aa AA seqDB search
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1077 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcccggagatggtccgcgggcaggtgttcgacgtgggg
ccgcgctacactaatctctcgtacatcggagaaggcgcctacggcatggtttgttctgct
tatgataatctcaacaaagttcgagttgctatcaagaaaatcagtccttttgagcaccag
acctactgtcagagaaccctgagagagataaaaatcctactgcgcttcagacatgagaac
atcatcggcatcaatgacatcatccgggcaccaaccattgagcagatgaaagatgtatat
atagtacaggacctcatggagacagatctttacaagctcttgaagacacagcacctcagc
aatgatcatatctgctattttctttatcagatcctgagaggattaaagtatatacattca
gctaatgttctgcaccgtgacctcaagccttccaacctcctgctgaacaccacttgtgat
ctcaagatctgtgactttggccttgcccgtgttgcagatccagaccatgatcatacaggg
ttcttgacagagtatgtagccacgcgttggtacagagctccagaaattatgttgaattcc
aagggttataccaagtccattgatatttggtctgtgggctgcatcctggcagagatgcta
tccaacaggcctatcttcccaggaaagcattaccttgaccagctgaatcacatcctgggt
attcttggatctccatcacaggaagatctgaattgtataataaatttaaaagctagaaac
tatttgctttctctcccgcacaaaaataaggtgccgtggaacaggttgttcccaaacgct
gactccaaagctctggatttactggataaaatgttgacatttaaccctcacaagaggatt
gaagttgaacaggctctggcccacccgtacctggagcagtattatgacccaagtgatgag
cccattgctgaagcaccattcaagtttgacatggagctggacgacttacctaaggagaag
ctcaaagaactcatttttgaagagactgctcgattccagccaggatacagatcttaa

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