KEGG   Rattus norvegicus (rat): 170911Help
Entry
170911            CDS       T01003                                 

Gene name
Pik3ca
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.1.137 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    170911 (Pik3ca)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    170911 (Pik3ca)
   04015 Rap1 signaling pathway
    170911 (Pik3ca)
   04012 ErbB signaling pathway
    170911 (Pik3ca)
   04370 VEGF signaling pathway
    170911 (Pik3ca)
   04630 Jak-STAT signaling pathway
    170911 (Pik3ca)
   04668 TNF signaling pathway
    170911 (Pik3ca)
   04066 HIF-1 signaling pathway
    170911 (Pik3ca)
   04068 FoxO signaling pathway
    170911 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    170911 (Pik3ca)
   04024 cAMP signaling pathway
    170911 (Pik3ca)
   04022 cGMP - PKG signaling pathway
    170911 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    170911 (Pik3ca)
   04152 AMPK signaling pathway
    170911 (Pik3ca)
   04150 mTOR signaling pathway
    170911 (Pik3ca)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    170911 (Pik3ca)
  Cell growth and death
   04210 Apoptosis
    170911 (Pik3ca)
  Cellular commiunity
   04510 Focal adhesion
    170911 (Pik3ca)
 Organismal Systems
  Immune system
   04611 Platelet activation
    170911 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    170911 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    170911 (Pik3ca)
   04660 T cell receptor signaling pathway
    170911 (Pik3ca)
   04662 B cell receptor signaling pathway
    170911 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    170911 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    170911 (Pik3ca)
   04670 Leukocyte transendothelial migration
    170911 (Pik3ca)
   04062 Chemokine signaling pathway
    170911 (Pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    170911 (Pik3ca)
   04915 Estrogen signaling pathway
    170911 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    170911 (Pik3ca)
   04917 Prolactin signaling pathway
    170911 (Pik3ca)
   04921 Oxytocin signaling pathway
    170911 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    170911 (Pik3ca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    170911 (Pik3ca)
  Digestive system
   04973 Carbohydrate digestion and absorption
    170911 (Pik3ca)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    170911 (Pik3ca)
  Nervous system
   04725 Cholinergic synapse
    170911 (Pik3ca)
   04722 Neurotrophin signaling pathway
    170911 (Pik3ca)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    170911 (Pik3ca)
  Development
   04380 Osteoclast differentiation
    170911 (Pik3ca)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    170911 (Pik3ca)
   05205 Proteoglycans in cancer
    170911 (Pik3ca)
   05203 Viral carcinogenesis
    170911 (Pik3ca)
   05210 Colorectal cancer
    170911 (Pik3ca)
   05212 Pancreatic cancer
    170911 (Pik3ca)
   05214 Glioma
    170911 (Pik3ca)
   05221 Acute myeloid leukemia
    170911 (Pik3ca)
   05220 Chronic myeloid leukemia
    170911 (Pik3ca)
   05218 Melanoma
    170911 (Pik3ca)
   05211 Renal cell carcinoma
    170911 (Pik3ca)
   05215 Prostate cancer
    170911 (Pik3ca)
   05213 Endometrial cancer
    170911 (Pik3ca)
   05222 Small cell lung cancer
    170911 (Pik3ca)
   05223 Non-small cell lung cancer
    170911 (Pik3ca)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    170911 (Pik3ca)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    170911 (Pik3ca)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    170911 (Pik3ca)
   05166 HTLV-I infection
    170911 (Pik3ca)
   05162 Measles
    170911 (Pik3ca)
   05164 Influenza A
    170911 (Pik3ca)
   05161 Hepatitis B
    170911 (Pik3ca)
   05160 Hepatitis C
    170911 (Pik3ca)
   05169 Epstein-Barr virus infection
    170911 (Pik3ca)
   05146 Amoebiasis
    170911 (Pik3ca)
   05145 Toxoplasmosis
    170911 (Pik3ca)
   05142 Chagas disease (American trypanosomiasis)
    170911 (Pik3ca)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     170911 (Pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
Position
2q25
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactcccaaatggaatgatagtgactttagaatgcctccgtgaggcc
acactagtcaccatcaagcatgaactgttcaaagaggccaggaaataccctctccatcag
cttctgcaagatgaatcatcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaatttttcgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaaccgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagacttccga
aggaacattctgaatgtttgcaaagaagccgtggacctgcgggatctcaactcgcctcat
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtgatagtctctcca
aacaacgacaagcagaagtacactctgaagatcaaccatgactgcgtgccagagcaagtc
attgctgaggccatcaggaagaagacccggagcatgttgctgtcctcggagcagctgaaa
ctctgtgtcttagaataccagggcaagtacattctcaaagtgtgtggctgtgatgagtac
ttcctagagaagtaccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaggagagcctgtactctcagctgccgatcgat
agcttcacaatgccatcctactccaggcgcatttccacagcgacaccctatatgaacggg
gagactgctacgaaatccctctgggttataaatagcgcgctcagaataaaaattctgtgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaatactcaaagagtcccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcc
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccacatgggttggaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagatatgtctgtgatcgaagagcatgccaattggtctgtg
tcccgagaagccggattcagttactctcatacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgtacccgggacccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggag
ctcctggactgtaactacccagaccccatggttcggagctttgctgtccggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcatccagcttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggttcggcctgctgttggagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaggtagaggccatggagaagctcatcaatctaactgacatcctcaag
caggagaagaaggatgagacacagaaggtacagatgaagttcttggttgaacagatgaga
cagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgacttacggcaagacatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcagatt
cagtgcaaaggaggcctgaaaggggcactgcagttcaacagccacacgctgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgacgcagccattgacctgttcactcggtcc
tgcgctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccgtttgttttgacgcaggatttc
ttaatagtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcgtacctagcaattcggcagcatgccaatctcttcatcaac
cttttctccatgatgcttggctccggaatgccagaactgcagtctttcgatgatattgca
tatattcgaaagactctagccttagacaaaactgagcaagaggctctggagtatttcaca
aagcaaatgaatgacgcacatcatggtggctggacaacaaaaatggactggatcttccac
accatcaagcagcatgcattgaactga

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