KEGG   Rattus norvegicus (rat): 25031Help
Entry
25031             CDS       T01003                                 

Gene name
Plcb4, Beta4aa, RATBETA4AA
Definition
phospholipase C, beta 4 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:rno00562]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:rno04015]
Environmental Information Processing; Signal transduction; Wnt signaling pathway [PATH:rno04310]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:rno04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:rno04070]
Cellular Processes; Cell communication; Gap junction [PATH:rno04540]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:rno04062]
Organismal Systems; Endocrine system; Insulin secretion [PATH:rno04911]
Organismal Systems; Endocrine system; GnRH signaling pathway [PATH:rno04912]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:rno04915]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:rno04921]
Organismal Systems; Endocrine system; Thyroid hormone synthesis [PATH:rno04918]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:rno04919]
Organismal Systems; Endocrine system; Melanogenesis [PATH:rno04916]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:rno04261]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH:rno04270]
Organismal Systems; Digestive system; Salivary secretion [PATH:rno04970]
Organismal Systems; Digestive system; Gastric acid secretion [PATH:rno04971]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:rno04972]
Organismal Systems; Excretory system; Endocrine and other factor-regulated calcium reabsorption [PATH:rno04961]
Organismal Systems; Nervous system; Glutamatergic synapse [PATH:rno04724]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:rno04725]
Organismal Systems; Nervous system; Dopaminergic synapse [PATH:rno04728]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:rno04726]
Organismal Systems; Nervous system; Long-term potentiation [PATH:rno04720]
Organismal Systems; Nervous system; Long-term depression [PATH:rno04730]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:rno04723]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:rno04750]
Organismal Systems; Environmental adaptation; Circadian entrainment [PATH:rno04713]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:rno05010]
Human Diseases; Neurodegenerative diseases; Huntington's disease [PATH:rno05016]
Human Diseases; Infectious diseases; Amoebiasis [PATH:rno05146]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:rno05142]
Human Diseases; Infectious diseases; African trypanosomiasis [PATH:rno05143]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
UniProt: 
Position
3q36
AA seq 1176 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLAAIPKDPKILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYQM
SKYCEDLFGDLLLKQALESHPLEPGRLLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESAADQEEEAHPEYKFGNELSADDFSHKEAVANSVKKGL
VTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESV
GLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQ
LNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG
TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNN
KLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGLGDIVDALSDPK
KFLSITEKRADQLRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTA
ALGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCT
QVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTSDHKSKVKEIVAQ
HTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAH
QAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKV
QLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3531 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttacgaatttaactggcagaaggaggtaccctctttcttgcaagaagga
gcagtttttgacagatatgaagaggaatctttcgtgtttgagcccaactgcctcttcaaa
gtggatgaattcggcttcttcctgacctggaagagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagcattcggctggcagccataccaaaggatcccaaaatcctg
gctgctctcgagtctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc
tgcagcggcacggatctggtgaatattggcttcacttacatggtggctgaaaacccagaa
ataactaagcaatgggtagaaggcctgagatcaatcattcacaacttcagggcaaacaac
gtcagtccgatgacatgcctcaagaaacactggatgaaactggcctttctgaccaacaca
agtggcaaaatcccagtgaggagtattactagaaccttcgcatcagggaaaacagaaaag
gtgatctttcaagcactcaaggaattaggtctccccagtggaaagaatgatgaaattgaa
cctgctgcatttacctatgaaaagttctatgaactgacacagaagatttgtcctcggaca
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaacgaacatcagcgagatcctcggctgaatgaaattttattc
ccgttttatgatgctaaaagagcaatgcagatcattgagatgtatgaacctgatgaagag
ttgaagaaaaaaggcctcatatccagtgatggattctgcagatatctcatgtcagatgaa
aatgcccccgtcttcctagatcgcttagaactttaccaggagatggaccaccccctggcc
cattacttcatcagttcctctcacaacacctatctcaccggccggcagtttggcggaaag
tcttcagtggaaatgtaccgacaagtcctcctggctggttgcaggtgtgtggaacttgac
tgttgggatggaaaaggtgaagatcaggaaccaataataactcacggaaaagcaatgtgt
acagacatcctttttaaggatgtaatccaggccatcaaggaaacagcgtttgtcacatca
gaatatcctgtaattctctcctttgaaaaccactgcagcaaatatcaacagtaccagatg
tccaagtattgtgaagatctatttggggatcttctgttgaaacaagcacttgagtcacat
ccacttgaaccagggaggctcttgccatctcctaatgacctcaaaagaaaaatactcatc
aaaaataaaaggctgaagcctgaagttgaaaaaaaacagctggaggctttgaaaagcatg
atggaggctggagaatcagctgccccggccagcatcttggaagatgacaatgaggaggaa
atagaaagcgcagctgatcaagaggaagaagcccaccctgaatacaagtttggaaatgaa
ctttctgccgatgacttcagtcacaaggaagcggttgcaaacagcgtcaagaagggcctg
gtcaccgtagaagatgagcaggcatggatggcatcttataaatacgtaggtgctaccacg
aatatccatccgtacttgtccacgatgatcaactatgcacagcctgtgaagtttcaaggt
ttccatgtggctgaagagcgcaacattcattataacatgtcttcttttaacgagtcggtt
ggccttggctacttgaagacgcacgcgattgagtttgtaaattacaataagcgacaaatg
agccgcatttaccccaagggagggcgagttgattccagtaattacatgcctcagattttc
tggaacgctggttgccagatggtttcactgaactatcaaaccccagatttagcgatgcaa
ttgaatcaaggaaaatttgagtataacggatcctgcggatacctcctcaagccagacttc
atgagacggcctgatcggacatttgatcccttctctgaaacccctgtggacggggttatt
gcagccacatgctcagtgcaggttatatcagggcagttcctgtcagataagaagatcggc
acatacgtggaagtcgatatgtacgggctgcccaccgacaccatacggaaggagttccga
acccgcatggttatgaacaatggactcaacccagtttacaatgaagaatcgttcgtgttt
cggaaggtgatcctgcctgacctggctgtcctgagaatcgctgtgtacgacgacaacaac
aagctcattggccagaggatccttcctctggatggcctccaggcaggttaccgacacatc
tccctgagaaatgagggaaacaaaccgttatcactgccaacaattttctgcaatatcgtt
cttaaaacatatgtgcctgatggattgggagatattgtggatgctctatccgatccaaag
aaattcctttcaatcacagagaagagagcagaccaattgagagcaatgggcattgaaact
agtgacatagcagatgtgcccagtgacacttccaaaaatgacaagaaaggcaaggccaac
ccagccaaagcgaatgtaacccctcagagcagctctgagctcagaccaaccaccacagct
gccctgggatctggccaggaagccaagaaaggtattgaacttatccctcaagtgaggata
gaagatttaaagcaaatgaaggcttacttgaagcatttaaagaaacaacaaaaggagtta
aactctttaaagaagaaacacgcaaaggagcacagtaccatgcagaagttacactgcaca
caagtggacaaaatcgtggcccagtatgacaaggagaagtcgactcatgagaaaatccta
gagaaggccatgaagaagaaggggggaagtaattgccttgaaataaaaaaagaaacagaa
attaagattcagaccctgacatcggatcacaaatctaaggtcaaggagattgtggcgcag
cacacaaaggagtggtcagaaatgatcaacacgcacagcgccgaggagcaggaaatccgg
gacctgcacctgagccagcagtgtgagctgctgaggaagctgctcatcaacgctcatgag
cagcagacccagcagctgaagctctcccatgacagggaaagcaaagagatgcgagcccat
caggctaagatttctatggaaaatagcaaagccatcagtcaagataaatctatcaagaat
aaggcagaacgggagaggcgagtcagggagttgaacagcagcaacactaagaagtttcta
gaagaaagaaagagactggcaatgaagcagtcgaaagaaatggatcagctgaaaaaggtc
cagctggagcacctagaattcctagagaaacagaatgagcaggcgaaggagatgcagcag
atggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatga

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