KEGG   Rattus norvegicus (rat): 25031Help
Entry
25031             CDS       T01003                                 

Gene name
Plcb4, Beta4aa, RATBETA4AA
Definition
phospholipase C, beta 4 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    25031 (Plcb4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    25031 (Plcb4)
   04310 Wnt signaling pathway
    25031 (Plcb4)
   04020 Calcium signaling pathway
    25031 (Plcb4)
   04070 Phosphatidylinositol signaling system
    25031 (Plcb4)
   04022 cGMP - PKG signaling pathway
    25031 (Plcb4)
 Cellular Processes
  Cell communication
   04540 Gap junction
    25031 (Plcb4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    25031 (Plcb4)
   04062 Chemokine signaling pathway
    25031 (Plcb4)
  Endocrine system
   04911 Insulin secretion
    25031 (Plcb4)
   04912 GnRH signaling pathway
    25031 (Plcb4)
   04915 Estrogen signaling pathway
    25031 (Plcb4)
   04921 Oxytocin signaling pathway
    25031 (Plcb4)
   04918 Thyroid hormone synthesis
    25031 (Plcb4)
   04919 Thyroid hormone signaling pathway
    25031 (Plcb4)
   04916 Melanogenesis
    25031 (Plcb4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    25031 (Plcb4)
   04270 Vascular smooth muscle contraction
    25031 (Plcb4)
  Digestive system
   04970 Salivary secretion
    25031 (Plcb4)
   04971 Gastric acid secretion
    25031 (Plcb4)
   04972 Pancreatic secretion
    25031 (Plcb4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    25031 (Plcb4)
  Nervous system
   04724 Glutamatergic synapse
    25031 (Plcb4)
   04725 Cholinergic synapse
    25031 (Plcb4)
   04728 Dopaminergic synapse
    25031 (Plcb4)
   04726 Serotonergic synapse
    25031 (Plcb4)
   04720 Long-term potentiation
    25031 (Plcb4)
   04730 Long-term depression
    25031 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    25031 (Plcb4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25031 (Plcb4)
  Environmental adaptation
   04713 Circadian entrainment
    25031 (Plcb4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    25031 (Plcb4)
   05016 Huntington's disease
    25031 (Plcb4)
  Infectious diseases
   05146 Amoebiasis
    25031 (Plcb4)
   05142 Chagas disease (American trypanosomiasis)
    25031 (Plcb4)
   05143 African trypanosomiasis
    25031 (Plcb4)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     25031 (Plcb4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
3q36
AA seq 1176 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLAAIPKDPKILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYQM
SKYCEDLFGDLLLKQALESHPLEPGRLLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESAADQEEEAHPEYKFGNELSADDFSHKEAVANSVKKGL
VTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESV
GLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQ
LNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIG
TYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNN
KLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGLGDIVDALSDPK
KFLSITEKRADQLRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTA
ALGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCT
QVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTSDHKSKVKEIVAQ
HTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAH
QAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKV
QLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3531 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttacgaatttaactggcagaaggaggtaccctctttcttgcaagaagga
gcagtttttgacagatatgaagaggaatctttcgtgtttgagcccaactgcctcttcaaa
gtggatgaattcggcttcttcctgacctggaagagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagcattcggctggcagccataccaaaggatcccaaaatcctg
gctgctctcgagtctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc
tgcagcggcacggatctggtgaatattggcttcacttacatggtggctgaaaacccagaa
ataactaagcaatgggtagaaggcctgagatcaatcattcacaacttcagggcaaacaac
gtcagtccgatgacatgcctcaagaaacactggatgaaactggcctttctgaccaacaca
agtggcaaaatcccagtgaggagtattactagaaccttcgcatcagggaaaacagaaaag
gtgatctttcaagcactcaaggaattaggtctccccagtggaaagaatgatgaaattgaa
cctgctgcatttacctatgaaaagttctatgaactgacacagaagatttgtcctcggaca
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaacgaacatcagcgagatcctcggctgaatgaaattttattc
ccgttttatgatgctaaaagagcaatgcagatcattgagatgtatgaacctgatgaagag
ttgaagaaaaaaggcctcatatccagtgatggattctgcagatatctcatgtcagatgaa
aatgcccccgtcttcctagatcgcttagaactttaccaggagatggaccaccccctggcc
cattacttcatcagttcctctcacaacacctatctcaccggccggcagtttggcggaaag
tcttcagtggaaatgtaccgacaagtcctcctggctggttgcaggtgtgtggaacttgac
tgttgggatggaaaaggtgaagatcaggaaccaataataactcacggaaaagcaatgtgt
acagacatcctttttaaggatgtaatccaggccatcaaggaaacagcgtttgtcacatca
gaatatcctgtaattctctcctttgaaaaccactgcagcaaatatcaacagtaccagatg
tccaagtattgtgaagatctatttggggatcttctgttgaaacaagcacttgagtcacat
ccacttgaaccagggaggctcttgccatctcctaatgacctcaaaagaaaaatactcatc
aaaaataaaaggctgaagcctgaagttgaaaaaaaacagctggaggctttgaaaagcatg
atggaggctggagaatcagctgccccggccagcatcttggaagatgacaatgaggaggaa
atagaaagcgcagctgatcaagaggaagaagcccaccctgaatacaagtttggaaatgaa
ctttctgccgatgacttcagtcacaaggaagcggttgcaaacagcgtcaagaagggcctg
gtcaccgtagaagatgagcaggcatggatggcatcttataaatacgtaggtgctaccacg
aatatccatccgtacttgtccacgatgatcaactatgcacagcctgtgaagtttcaaggt
ttccatgtggctgaagagcgcaacattcattataacatgtcttcttttaacgagtcggtt
ggccttggctacttgaagacgcacgcgattgagtttgtaaattacaataagcgacaaatg
agccgcatttaccccaagggagggcgagttgattccagtaattacatgcctcagattttc
tggaacgctggttgccagatggtttcactgaactatcaaaccccagatttagcgatgcaa
ttgaatcaaggaaaatttgagtataacggatcctgcggatacctcctcaagccagacttc
atgagacggcctgatcggacatttgatcccttctctgaaacccctgtggacggggttatt
gcagccacatgctcagtgcaggttatatcagggcagttcctgtcagataagaagatcggc
acatacgtggaagtcgatatgtacgggctgcccaccgacaccatacggaaggagttccga
acccgcatggttatgaacaatggactcaacccagtttacaatgaagaatcgttcgtgttt
cggaaggtgatcctgcctgacctggctgtcctgagaatcgctgtgtacgacgacaacaac
aagctcattggccagaggatccttcctctggatggcctccaggcaggttaccgacacatc
tccctgagaaatgagggaaacaaaccgttatcactgccaacaattttctgcaatatcgtt
cttaaaacatatgtgcctgatggattgggagatattgtggatgctctatccgatccaaag
aaattcctttcaatcacagagaagagagcagaccaattgagagcaatgggcattgaaact
agtgacatagcagatgtgcccagtgacacttccaaaaatgacaagaaaggcaaggccaac
ccagccaaagcgaatgtaacccctcagagcagctctgagctcagaccaaccaccacagct
gccctgggatctggccaggaagccaagaaaggtattgaacttatccctcaagtgaggata
gaagatttaaagcaaatgaaggcttacttgaagcatttaaagaaacaacaaaaggagtta
aactctttaaagaagaaacacgcaaaggagcacagtaccatgcagaagttacactgcaca
caagtggacaaaatcgtggcccagtatgacaaggagaagtcgactcatgagaaaatccta
gagaaggccatgaagaagaaggggggaagtaattgccttgaaataaaaaaagaaacagaa
attaagattcagaccctgacatcggatcacaaatctaaggtcaaggagattgtggcgcag
cacacaaaggagtggtcagaaatgatcaacacgcacagcgccgaggagcaggaaatccgg
gacctgcacctgagccagcagtgtgagctgctgaggaagctgctcatcaacgctcatgag
cagcagacccagcagctgaagctctcccatgacagggaaagcaaagagatgcgagcccat
caggctaagatttctatggaaaatagcaaagccatcagtcaagataaatctatcaagaat
aaggcagaacgggagaggcgagtcagggagttgaacagcagcaacactaagaagtttcta
gaagaaagaaagagactggcaatgaagcagtcgaaagaaatggatcagctgaaaaaggtc
cagctggagcacctagaattcctagagaaacagaatgagcaggcgaaggagatgcagcag
atggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatga

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