KEGG   Rattus norvegicus (rat): 25272Help
Entry
25272             CDS       T01003                                 

Gene name
Mapk10, Jnk3, SAPKC, SAPb, Serk2
Definition
(RefSeq) mitogen activated protein kinase 10
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04024  cAMP signaling pathway
rno04068  FoxO signaling pathway
rno04071  Sphingolipid signaling pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04141  Protein processing in endoplasmic reticulum
rno04210  Apoptosis
rno04215  Apoptosis - multiple species
rno04217  Necroptosis
rno04310  Wnt signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04530  Tight junction
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04657  IL-17 signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04664  Fc epsilon RI signaling pathway
rno04668  TNF signaling pathway
rno04722  Neurotrophin signaling pathway
rno04723  Retrograde endocannabinoid signaling
rno04728  Dopaminergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04917  Prolactin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04926  Relaxin signaling pathway
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease (NAFLD)
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno05132  Salmonella infection
rno05133  Pertussis
rno05142  Chagas disease (American trypanosomiasis)
rno05145  Toxoplasmosis
rno05152  Tuberculosis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05164  Influenza A
rno05167  Kaposi's sarcoma-associated herpesvirus infection
rno05168  Herpes simplex infection
rno05169  Epstein-Barr virus infection
rno05200  Pathways in cancer
rno05210  Colorectal cancer
rno05212  Pancreatic cancer
rno05231  Choline metabolism in cancer
rno05418  Fluid shear stress and atherosclerosis
Module
rno_M00688  MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:rno00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    25272 (Mapk10)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    25272 (Mapk10)
   04010 MAPK signaling pathway
    25272 (Mapk10)
   04012 ErbB signaling pathway
    25272 (Mapk10)
   04310 Wnt signaling pathway
    25272 (Mapk10)
   04668 TNF signaling pathway
    25272 (Mapk10)
   04068 FoxO signaling pathway
    25272 (Mapk10)
   04071 Sphingolipid signaling pathway
    25272 (Mapk10)
   04024 cAMP signaling pathway
    25272 (Mapk10)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    25272 (Mapk10)
   04137 Mitophagy - animal
    25272 (Mapk10)
  Cell growth and death
   04210 Apoptosis
    25272 (Mapk10)
   04215 Apoptosis - multiple species
    25272 (Mapk10)
   04217 Necroptosis
    25272 (Mapk10)
  Cellular community - eukaryotes
   04510 Focal adhesion
    25272 (Mapk10)
   04530 Tight junction
    25272 (Mapk10)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    25272 (Mapk10)
   04621 NOD-like receptor signaling pathway
    25272 (Mapk10)
   04622 RIG-I-like receptor signaling pathway
    25272 (Mapk10)
   04625 C-type lectin receptor signaling pathway
    25272 (Mapk10)
   04658 Th1 and Th2 cell differentiation
    25272 (Mapk10)
   04659 Th17 cell differentiation
    25272 (Mapk10)
   04657 IL-17 signaling pathway
    25272 (Mapk10)
   04664 Fc epsilon RI signaling pathway
    25272 (Mapk10)
  Endocrine system
   04910 Insulin signaling pathway
    25272 (Mapk10)
   04920 Adipocytokine signaling pathway
    25272 (Mapk10)
   04912 GnRH signaling pathway
    25272 (Mapk10)
   04914 Progesterone-mediated oocyte maturation
    25272 (Mapk10)
   04917 Prolactin signaling pathway
    25272 (Mapk10)
   04926 Relaxin signaling pathway
    25272 (Mapk10)
  Nervous system
   04728 Dopaminergic synapse
    25272 (Mapk10)
   04723 Retrograde endocannabinoid signaling
    25272 (Mapk10)
   04722 Neurotrophin signaling pathway
    25272 (Mapk10)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25272 (Mapk10)
  Development
   04380 Osteoclast differentiation
    25272 (Mapk10)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    25272 (Mapk10)
   05231 Choline metabolism in cancer
    25272 (Mapk10)
   05210 Colorectal cancer
    25272 (Mapk10)
   05212 Pancreatic cancer
    25272 (Mapk10)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    25272 (Mapk10)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    25272 (Mapk10)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    25272 (Mapk10)
   04931 Insulin resistance
    25272 (Mapk10)
   04933 AGE-RAGE signaling pathway in diabetic complications
    25272 (Mapk10)
  Infectious diseases
   05132 Salmonella infection
    25272 (Mapk10)
   05133 Pertussis
    25272 (Mapk10)
   05152 Tuberculosis
    25272 (Mapk10)
   05164 Influenza A
    25272 (Mapk10)
   05161 Hepatitis B
    25272 (Mapk10)
   05160 Hepatitis C
    25272 (Mapk10)
   05168 Herpes simplex infection
    25272 (Mapk10)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    25272 (Mapk10)
   05169 Epstein-Barr virus infection
    25272 (Mapk10)
   05145 Toxoplasmosis
    25272 (Mapk10)
   05142 Chagas disease (American trypanosomiasis)
    25272 (Mapk10)
  Drug resistance
   01522 Endocrine resistance
    25272 (Mapk10)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     25272 (Mapk10)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   25272 (Mapk10)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kdo Kinase-like RIO1 APH FTA2 Haspin_kinase
Motif
Other DBs
NCBI-GeneID: 25272
NCBI-ProteinID: NP_036938
RGD: 3663
Ensembl: ENSRNOG00000002079
Vega: OTTRNOG00000002125
UniProt: P49187 B0VXR6
Position
14p22
AA seq 426 aa AA seqDB search
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG
PLGCCR
NT seq 1281 nt NT seq  +upstreamnt  +downstreamnt
atgagcaaaagcaaggtagataaccagttctacagtgtggaagtgggagactcaaccttc
acagttctaaagcgctaccagaacctgaagccgatcggctctggggctcagggaatagtt
tgtgctgcgtatgacgctgtcctcgacagaaatgtggccattaagaagctcagcagaccc
ttccagaaccaaactcatgccaagagggcttaccgggagctggtcctcatgaagtgtgtg
aaccataaaaacattattagcttattaaatgtctttacaccccagaaaacactggaggag
ttccaagatgtttacttagtgatggaactgatggacgccaacttgtgtcaggtgattcag
atggagctggaccacgagcggatgtcgtacttgctgtaccagatgctgtgcggcatcaaa
cacctccactccgctgggatcatccacagggacttaaaacccagtaacatcgtagtcaag
tctgattgcacactgaaaatcctggactttggactggccaggacagcgggcacaagcttc
atgatgactccgtatgtggtgacgagatattacagagcccccgaggtcatcctgggcatg
ggctacaaggagaacgtggacatatggtctgtgggctgcatcatgggagaaatggttcgt
cacaaaatcctctttcccggaagggactatattgaccagtggaacaaagtcatagagcag
ctaggaactccgtgtccagaattcatgaagaaattgcagcccaccgtcagaaactacgtg
gagaaccggcccaagtatgcaggcctcaccttccccaagctctttccagattccctcttc
ccagcggattccgagcacaataaacttaaagccagccaagccagggacttgttgtcaaag
atgttagtgattgacccagcgaagaggatatcggtggatgacgcattgcagcatccgtac
atcaacgtttggtacgaccctgctgaagtggaggcgcctccgcctcagatatatgacaag
caactggatgaaagggagcacaccatcgaagaatggaaagaactcatctacaaggaagta
atgaactcagaagagaagactaagaacggcgtagtcaaaggccagccctcaccttcaggt
gcagcagtgaacagcagtgagagtctccctccatcctcgtctgtcaacgacatctcctcc
atgtccaccgaccagaccctcgcatccgacactgacagcagcctggaagcctcggcggga
ccgctgggttgttgcaggtga

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