KEGG   Rattus norvegicus (rat): 25467Help
Entry
25467             CDS       T01003                                 

Gene name
Irs1, IRS1IRM
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
rno  Rattus norvegicus (rat)
Pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Class
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:rno04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:rno04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:rno04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:rno04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:rno04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:rno04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:rno04722]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:rno05206]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:rno04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:rno04932]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
9q34
AA seq 1235 aa AA seqDB search
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH
HDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRL
CLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVV
AQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRT
ESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRL
HPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGF
ISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYIL
SRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSV
VSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSS
NLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMM
MSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKL
LPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGAR
HQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKV
DTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEF
GSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVEL
GRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAE
KVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNH
NQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFE
NVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPP
HQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ
NT seq 3708 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggataccgatggcttctcagacgtgcgcaaggtgggttacctgcgc
aaacccaagagtatgcataagcgctttttcgtgctgcgggcggccagcgaggccgggggc
ccggcgcgcctggagtattatgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgagacgaacactttgccattgcggcggatagcgag
gctgaacaagacagctggtaccaggctcttctgcagctgcataatcgggcaaaggcccac
catgacggggctggaggaggctgcggtggtagctgcagcggcagctctggcgtcggagag
gcaggggaggacttgagctatgacacgggcccaggacccgcgttcaaggaggtctggcag
gttatcctgaaacccaagggcttaggtcagacaaagaacttgattggtatctaccgcctc
tgcctgaccagcaagaccatcagctttgtgaagctcaactctgaggctgccgctgtggtg
ctgcagctgatgaacatcagacgctgtggccactcagagaacttcttcttcatcgaggtg
gggcggtcagctgtgaccgggcccggcgagttctggatgcaagtggatgactccgtggtg
gcccagaacatgcatgagaccattctagaggccatgcgggccatgagcgatgagtttcgc
ccgcgcacgaaaagccaatcttcatccagttgctccaaccccatcagtgttcccctgcgc
aggcaccatctcaacaatcctccgcccagccaagtggggctgactcggagatctcgaact
gagagcatcactgccacctcccctgccagtatggtgggtgggaaaccaggttccttcagg
gtgcgtgcctccagcgatggcgaaggcaccatgtcccgtccagcatcagtggatggcagt
cctgtgagccctagcaccaacaggacccacgcccatcggcatcgaggcagctccaggttg
caccccccactcaaccacagccgctccatccctatgccttcttcacgatgctccccttca
gccaccagcccagtgagcctgtcatccagtagtaccagtggccacggctccacttcagac
tgtctcttcccgaggcgctctagtgcttccgtgtccggttctcctagcgatggcggtttc
atctcttctgatgagtatggctctagtccctgcgatttccgaagttccttccgcagtgtc
accccagattccctgggccacaccccaccagccaggggtgaggaggagctgagcaactat
atctgcatgggtggcaagggagcctccaccttgacagctcccaatggtcactacattttg
tctaggggtggcaacggccatcgctacatcccaggtgctaccatggggacaagcccggcg
ctgactggagacgaagccgctggtgcagcagatctggataaccggtttcggaagagaact
cactcggctggcacgtcccccaccatatcccaccagaagaccccctcgcagtcctcagtg
gtttctattgaggaatatacagagatgatgcccgctgcctacccaccaggaggtggcagt
ggaggccgactgcccggctaccggcattccgccttcgtgcccacccactcctatcccgag
gagggtctagagatgcaccacttggaacgtcgtgggggccaccaccgtccagactcctcc
aacctccacaccgatgatggctacatgcccatgtctcccggagtggctccagtgcccagc
aaccgcaaaggaaatggggactatatgcccatgagccccaagagtgtatctgccccccag
cagatcattaaccccatcaggcgccacccacagagagtggaccccaatggctacatgatg
atgtctcccagtggtagttgctctcctgacattggaggtgggtcttgcagcagtagcagc
atcagcgcagccccttctgggagcagctatgggaagccatggacaaacggagtagggggg
caccatacccatgcccttccccatgccaaacctcctgttgagagcggtggtggtaagctc
ttgccttgcactggtgactacatgaacatgtcgccagtgggagattccaacaccagcagc
ccctcagaatgctactatggcccagaagatccccagcacaagcctgtcctctcctactac
tcattaccaaggtcctttaagcacacccagcgccctggggagccagaggagggtgccagg
caccagcatcttcgtctctcttcaagctctggacgccttcgctataccgcaactgccgaa
gattcctcctcttccaccagcagcgacagcctgggtgggggttactgtggggctaggcca
gagtctagcgtcacacatccccaccaccatgccttgcagccccatctgcctcgaaaggta
gacacagctgcacagaccaacagccgcctggctcgacccacaaggctgtccttgggggat
cccaaggcaagcactttaccccgggtacgagagcaacagcagcagcagcaacagcagcag
cagtcttccctgcaccctcccgagcccaaaagcccaggagaatatgtgaatattgaattc
gggagtggccagccaggctatttagctggccctgcaacttcccgtagctccccttcagtt
cgatgtctaccccagctccacccagctcccagagaagagactggctcggaagagtacatg
aacatggacttggggccaggccggagggcaacctggcaggagagtggtggagttgagttg
ggcagagtaggccctgcacctccaggggctgcttccatttgtaggccaacccggtcggtg
ccaaatagccgtggtgattacatgaccatgcagataggttgtcctcgtcaaagctatgtg
gatacctcaccagtggccccagtcagctatgctgacatgcggacaggcattgctgcagag
aaggtgagcctgcccagaaccacaggagctgccccccctccatcctccacagcctctgct
tctgcttctgttacacctcaaggggccgctgagcaggccgctcactcttccttgctggga
ggccctcagggacctgggggcatgagcgcattcaccagggtgaacctaagtcccaaccat
aaccagagtgccaaagtgattcgtgcagacactcaaggctgccggaggaggcacagctcc
gagaccttctcggcgcctacgcgggctgccaacacagtgtcttttggagcaggggctgca
ggagggggcagcggtggtggcagtgaggatgtgaaacgccacagctctgcatcctttgag
aatgtgtggctgagacccggggatctagggggagcatccaaggagtcggctccagggtgc
ggggctgccgggggattggagaagagtcttaactatatagacttggatttggtcaaggat
gttaagcagcaccctcaagactgcccctctcaacagcagtccctgccaccccctccccct
caccaacccttaggcagcaatgagggcagctccccaagacgctccagtgaggatttaagc
acctatgccagcatcaacttccagaagcaaccagaggaccgtcaatag

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