KEGG R.norvegicus: 25537

Rattus norvegicus (rat): 25537

Entry

25537 CDS R.norvegicus

Gene name Rock2

Definition Rho-associated coiled-coil containing protein kinase 2 (EC:2.7.11.1)

Orthology K04514 Rho-associated, coiled-coil containing protein kinase
[EC:2.7.11.1]

Pathway rno04062 Chemokine signaling pathway
rno04270 Vascular smooth muscle contraction
rno04310 Wnt signaling pathway
rno04350 TGF-beta signaling pathway
rno04360 Axon guidance
rno04510 Focal adhesion
rno04670 Leukocyte transendothelial migration
rno04810 Regulation of actin cytoskeleton

Class Metabolism; Enzyme Families; Protein kinases
Environmental Information Processing; Signal Transduction; Wnt
signaling pathway [PATH:rno04310]
Environmental Information Processing; Signal Transduction; TGF-beta
signaling pathway [PATH:rno04350]
Cellular Processes; Cell Motility; Regulation of actin cytoskeleton
[PATH:rno04810]
Cellular Processes; Cell Communication; Focal adhesion
[PATH:rno04510]
Organismal Systems; Immune System; Leukocyte transendothelial
migration [PATH:rno04670]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Circulatory System; Vascular smooth muscle
contraction [PATH:rno04270]
Organismal Systems; Development; Axon guidance [PATH:rno04360]

SSDB

Motif Pfam: Pkinase Rho_Binding Pkinase_Tyr PH Pkinase_C C1_1
Myosin_tail_1 APH
PROSITE: PROTEIN_KINASE_ST PROTEIN_KINASE_ATP PH_DOMAIN ZF_DAG_PE_2
PROTEIN_KINASE_DOM AGC_KINASE_CTER

Other DBs NCBI-GI: 6981478
NCBI-GeneID: 25537
RGD: 3590
RATMAP: ENSRNOG00000004496
Ensembl: ENSRNOG00000004496
UniProt: Q62868

Structure

PDB: 2ROV 2ROW

Position 6q15-q16

AA seq 1379 aa
MPGAPEAAAGDGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNID
NFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMI
KRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEK
WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT
AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDH
KNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKSASFFKNDQWNWDNIRETAA
PVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCR
ENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEIT
FRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQS
SQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLL
ETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTGKTLLAKVELEK
RQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEEAK
SEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDV
RNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNAELR
KERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERD
SLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIA
SLEETNRTLTSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKAQFEKQLLTERT
LKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELN
EMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDDGFP
ESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVR
PVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKGHEFIPTLYH
FPTNCEACMKPLWHMFKPPPALECSRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLL
LANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS

NT seq 4140 nt +upstreamnt +downstreamnt
atgcccggcgcccccgaggccgcggccggggacggggcgggcgcgggtcgtcagaggaag
ctggaggcgctcatccgagaccctcgctcgcccatcaacgtggaaagcctgctggatggc
ttaaattccttggtccttgatttggattttcctgctttgaggaaaaataaaaatatagat
aatttcctaaatagatatgagaaaattgtgaaaaaaatcagaggtttacagatgaaagca
gaagactatgatgttgtaaaagttattggaagaggtgcttttggtgaagttcagttggtt
cgtcataaggcatcacagaaggtttatgcaatgaagcttcttagtaaatttgaaatgata
aaaagatcagattctgcttttttctgggaagaaagagatattatggcttttgctaacagt
ccgtgggtggttcagctcttttgtgcctttcaagatgacaggtatctgtacatggtgatg
gagtacatgccaggtggagaccttgttaacctgatgagcaattatgatgtgcctgagaag
tgggccaagttttatactgctgaagtcgtgcttgcactggatgcaatacactccatgggc
ttaatacacagagatgtgaagcccgataacatgctattggataaacacggacatctaaaa
ttagcagattttggcacatgtatgaaaatggatgaaacaggcatggtgcattgtgataca
gcagttggaactccagactacatatcacctgaggttctgaaatcacaaggaggtgatggt
tactatggacgagaatgtgattggtggtctgtaggtgttttcctttttgagatgttagta
ggggacactccattttatgcagattcacttgtaggaacctacagcaaaattatggatcat
aaaaattcactgtgttttcctgaagatacagaaatttctaaacatgcgaagaatctcata
tgtgccttcttaacagacagggaggtacgacttggaagaaatggggtagaagaaatcaaa
tcagcatccttctttaagaatgatcagtggaattgggataacataagagagacggcagct
ccagtggtgcctgagctcagcagtgacatagacagcagcaactttgatgacattgaggat
gacaaaggcgatgtagagaccttcccgattcctaaagcttttgtgggaaatcagctgcct
tttataggatttacctactttagagaaaatttgttactaagtgattctccaccttgtaga
gaaaatgatgcaatacaaacaaggaaaagtgaagaaagtcaggagattcagaaaaaatta
tatgcactagaagaacaccttagcagtgaggtacaagccaaggaggaactggaacagaag
tgcaagtctattaatactcgtctagagaaaacagcaaaggaactagaagaagagattacc
tttaggaaaaatgtggaatcaacattaagacagctagaaagagaaaaggcccttcttcag
cacaaaaatgcagaatatcaacggaaagctgatcatgaagctgacaagaaacggaatttg
gaaaatgatgttaacagcttaaaagatcaacttgaagatttgaagaaaagaaaccagagc
tctcagatatccactgagaaggtcaatcagctccagaaacaactggatgaagctaatgct
ttgctaagaacagagtctgatactgcagcacggttaagaaaaacccaggcagaaagttcc
aaacagattcagcagctggaatctaacaatagagatctacaagataaaaactgcctgctt
gaaactgccaagttaaaacttgagaaggaatttatcaatcttcagtcagctctagaatct
gaaagaagggaccggacccatggatcagagataattaatgatttacaaggtagaatatct
gggttggaagaagatttgaagactggcaaaaccttactagcaaaagtagagctggagaag
agacagctgcaggagaagctcactgacttagagaaggaaaagagcaacatggaaatagat
atgacatatcaactgaaagttatacagcagagtttagaacaagaagaagctgaacacaag
accacaaaagcacgactagcggataaaaataagatctatgaatccattgaagaagctaaa
tcagaagccatgaaagaaatggagaagaagctgttggaagagaggtctttaaagcagaaa
gtggagaacctactcctggaagccgagaagagatgttctatattggattgtgacctcaaa
cagtctcagcagaaactgaatgagctgctgaagcagaaagatgtgctgaatgaggatgtt
agaaatttgacattaaaaatagagcaggaaactcagaagcgttgtcttatgcaaaatgac
ctgaagatgcagacccagcaagttaacaccctaaaaatgtcagaaaagcaaataaaacaa
gaaaataatcatcttatggaaatgaaaatgaacttggaaaagcaaaatgctgaacttcga
aaagagcggcaggatgcagatgggcagatgaaggaactgcaagaccaacttgaagcagag
cagtatttctcaaccctctataaaacacaagttagagaacttaaagaagaaaatgaagag
aaaactaaactttgtaaagagttgcagcagaaaaagcaggatttacaggatgaaagagac
tccttggctgcccagctggagatcaccctcaccaaagcagactctgagcagctggctcgc
tccattgctgaggagcaatactctgacttggaaaaagagaagatcatgaaagagctggaa
atcaaagagatgatggctagacacaaacaagagcttactgaaaaggacgctacaattgca
tcccttgaagaaacaaatagaacactaactagtgatgttgcaaatcttgcaaacgagaaa
gaagaactaaacaacaagttgaaagatacccaagaacaactgtcaaagttgaaagatgaa
gagatcagtgcagcggctattaaagcacagtttgagaagcagctgctgactgagcgaaca
ctcaagactcaagctgtgaataagttggcagagatcatgaatcgaaaagaacctgtcaag
cgtggtagtgacacagatgtgcgaagaaaagaaaaggaaaacagaaaattacatatggag
cttaagtctgaacgtgaaaaattgacacaacagatgatcaaatatcagaaagaactgaat
gaaatgcaggctcaaatagctgaagagagccaaattcgaatagaactgcagatgaccctg
gacagtaaagacagtgacattgaacagcttcggtcgcagctccaggccttgcatattggt
atggacagttccagtataggcagtggaccaggggatgctgagcctgatgacggatttcca
gaatcacgattagaaggatggctgtcgttgcctgtgcggaacaacactaaaaagtttgga
tgggttaagaagtatgtgattgtaagcagcaagaagattcttttctatgatagtgaacaa
gataaagagcagtctaacccttacatggtgttagacatagacaagctatttcatgtccga
cctgttactcagacagatgtatacagagcagatgctaaagaaattccaaggatatttcag
atcctgtatgccaatgaaggagaaagtaaaaaggaaccagaatttccagtggaaccagtg
ggagaaaaatctaattatatttgccacaaaggacatgagtttattcctactctttatcac
ttcccaaccaactgtgaggcctgtatgaagccactgtggcacatgtttaaacctcctcct
gctctagagtgcagtagatgccacattaaatgtcataaagatcacatggacaaaaaggaa
gagatcatagccccctgcaaagtttattatgatatatcatcggcaaagaatctgttgtta
ttagcaaattcaacggaagaacagcagaaatgggttagtcggttggtgaaaaagatacct
aaaaagcctccagctccagacccttttgcccgatcatcccctagaacctcaatgaaaata
caacaaaaccagtccattcggcggcccagtcgacagcttgctccaaacaaaccaagctaa

All links

Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (2)   
   UNIGENE (1)   
   ENSEMBL-RNO (1)   
   RATMAP-RNO (1)   
   RGD-RNO (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (2)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
3D Structure (2)   
   PDB (2)   
Protein domain (14)   
   Pfam (8)   
   PROSITE (6)   
All databases (41)

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