KEGG   Rattus norvegicus (rat): 25741Help
Entry
25741             CDS       T01003                                 

Gene name
Pfkl, ATP-PFK, PFK-L
Definition
phosphofructokinase, liver (EC:2.7.1.11)
Orthology
K00850  
6-phosphofructokinase 1 [EC:2.7.1.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Galactose metabolism
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
AMPK signaling pathway
Central carbon metabolism in cancer
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    25741 (Pfkl)
   01230 Biosynthesis of amino acids
    25741 (Pfkl)
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    25741 (Pfkl)
   00030 Pentose phosphate pathway
    25741 (Pfkl)
   00051 Fructose and mannose metabolism
    25741 (Pfkl)
   00052 Galactose metabolism
    25741 (Pfkl)
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    25741 (Pfkl)
   04152 AMPK signaling pathway
    25741 (Pfkl)
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    25741 (Pfkl)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.11  6-phosphofructokinase
     25741 (Pfkl)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     25741 (Pfkl)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
20p12
AA seq 780 aa AA seqDB search
MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAAYNLLQHGITNLCVIGGDG
SLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLSIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKDVQK
AMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISEGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKPHLEAI
VENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFS
SVTELKKETDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF
NT seq 2343 nt NT seq  +upstreamnt  +downstreamnt
atggctaccgtggacctggagaagttgcggatgtcgggggctggcaaggccatcggagtg
ctgacaagcggcggtgacgcgcaaggtatgaatgctgctgtcagggctgtgactcgtatg
ggcatatatgtgggggccaaagtcttcctcatctacgagggctacgagggcctcgtggaa
ggaggcgagaacatcaagccagccaactggctcagtgtctccaacatcatccagctgggc
ggcaccatcattggcagtgcccgctgtaaggccttcactacgagggaagggcgcctggca
gcggcctacaatctgctccaacacggcatcaccaacctgtgtgtcatcggtggggatggc
agcctcacgggggccaacatcttccgcaacgagtggggcagcttgctggaggaactggtg
aaggaaggcaagatctcagagtccacagctcagaactacgcacacttgagcatcgccggt
ctggtgggctccatcgacaacgacttctgcggcaccgacatgaccatcggcacggactcg
gccctgcaccggatcatggaggtcatcgacgccatcaccaccactgcccagagccaccag
aggacctttgtgttggaggtgatgggacggcactgcgggtacctggcgctggtgtctgcg
ctggcctccggggctgattggctgttcatccctgaagcgcccccggaggatggctgggag
aacttcatgtgtgagaggctgggggagactcggagccgggggtctcgactgaacatcatc
atcatcgcggagggtgccatcgaccggcatggaaagcctatctcatccagctacgtgaaa
gacctggtggttcagaggctgggcttcgatacacgagtgaccgtgctgggccacgtacag
cgaggagggacaccctcggcctttgaccgagtcctgagtagcaagatgggtatggaggcc
gtgatggcgctgctggaggccacgccggacacgccggcctgcgtggtcagcctctccggg
aatcagtctgtgcggctgcctctcatggagtgtgtgcaagtgacgaaggatgtgcagaag
gccatggatgagaagaggtttgacgaggccatccagctccgtggcaggagcttcgagaac
aactggaaaatttacaagctcctcgcccaccagaaggtgtctaaggagaagtccaacttc
tccctggccatcctgaatgtgggagctccagcggccggcatgaacgcagccgtgcgctcc
gcggtacgcactggcatctccgagggacacacagtgtacgttgtgcatgatggctttgag
ggcctggccaagggtcaggtgcaagaagtgggctggcatgatgtggcaggttggctagga
cgtggtggctcaatgctggggaccaagaggaccctgcccaagccccacctggaggccatt
gtagaaaatctccgtacctacaacattcatgccctgttggtgatcggtggctttgaggcc
tacgagggtgtgctgcagctggtggaggctagggggcgctacgaggaactctgtatcgtc
atgtgcgtcatcccagccaccatcagcaacaatgtccctggcactgacttcagcctgggc
tcggacacggccgtcaacgctgcaatggagagttgtgaccgcatcaaacaatcggcctcg
gggacaaagcggcgtgtgttcattgtagagaccatggggggctactgtggctacctggcc
actgtgacaggcattgctgtgggcgccgatgccgcctacgtctttgaggaccctttcaac
atccacgacttgaaggccaatgtggagcatatgacagagaagatgaagacagacatccag
aggggcctggtgctccggaacgagaagtgtcacgaacactacaccacggaattcctatac
aacctatactcctcggaaggcagaggtgtgttcgactgcaggaccaacgtgctgggccac
ctgcagcagggtggcgctccaacccccttcgaccggaactatgggaccaaactgggggtg
aaggccatgttgtggatgtcggagaagctgcgtgatgtctaccgcaaagggcgggtgttt
gccaatgctccggactcagcctgtgtgatcggcctgaggaagaaggtggtggccttcagt
tcggtcacagaactcaagaaagagacagattttgagcaccgtatgccgcgggagcagtgg
tggctgaatctgcggctgatgctgaagatgttggcacactaccgcatcagcatggccgac
tacgtgtctggggagctggagcacgtcacacgccgcaccttgagcatagacaagggtttc
tga

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