KEGG   Rattus norvegicus (rat): 287398Help
Entry
287398            CDS       T01003                                 

Gene name
Map2k4, MKK4, Sek1
Definition
(RefSeq) mitogen activated protein kinase kinase 4
  KO
K04430  
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Toll-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
GnRH signaling pathway
Chagas disease (American trypanosomiasis)
Hepatitis B
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Fluid shear stress and atherosclerosis
Module
MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    287398 (Map2k4)
   04012 ErbB signaling pathway
    287398 (Map2k4)
   04668 TNF signaling pathway
    287398 (Map2k4)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    287398 (Map2k4)
   04664 Fc epsilon RI signaling pathway
    287398 (Map2k4)
  Endocrine system
   04912 GnRH signaling pathway
    287398 (Map2k4)
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    287398 (Map2k4)
  Infectious diseases
   05166 HTLV-I infection
    287398 (Map2k4)
   05164 Influenza A
    287398 (Map2k4)
   05161 Hepatitis B
    287398 (Map2k4)
   05169 Epstein-Barr virus infection
    287398 (Map2k4)
   05142 Chagas disease (American trypanosomiasis)
    287398 (Map2k4)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     287398 (Map2k4)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   287398 (Map2k4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
RGD: 
UniProt: 
Position
10q24
AA seq 397 aa AA seqDB search
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLN
PNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK
PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS
TSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGN
IKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT
GRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELL
KHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
NT seq 1194 nt NT seq  +upstreamnt  +downstreamnt
atggcggctccgagcccgagcggcggcggcggctccgggggcggtggcggcaccccgggg
cccatcgggcctccagcttctggccacccggcggtcagcagcatgcagggtaaacgcaaa
gccctgaagttgaattttgcaaatccacctgtcaaatcgacagcacggtttactctgaat
cctaataccacaggagtccagaacccacacatagagagactgagaacccacagcattgag
tcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagaggacttg
aaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtccacaaa
ccaagtgggcagataatggcagttaaaagaatacgatcaactgtggatgaaaaagaacaa
aaacaacttctcatggatttggatgtagtgatgcggagtagtgattgcccatacattgtt
cagttctatggtgcactcttcagagagggcgactgttggatctgtatggagctcatgtct
acctcgttcgataagttttacaaatatgtatatagtgtgttagatgatgtgatcccggaa
gagatcttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaagaaaac
ttgaaaattattcacagagacatcaaaccttccaatattcttctggacaggagtggaaat
ataaagctctgtgacttcggcatcagtggacagctcgtggactctattgccaagacgaga
gatgctggctgtaggccgtatatggcacctgaaagaatagacccaagtgcatcaagacaa
gggtatgatgtccgctctgatgtctggagtttggggatcacattgtacgagttggccaca
ggccgatttccttatccaaagtggaatagtgtatttgatcagctaacacaagtggtgaaa
ggagaccctccccagctgagtaattccgaagaaagggagttctcccccagtttcatcaac
tttgtcaacttgtgccttacgaaggacgagtccaaaaggccaaagtacaaagagcttctg
aaacatccctttattttgatgtatgaagaacgtactgtagaggtcgcatgctatgtttgt
aaaatcctggatcagatgccagctactcccagctctcccatgtatgtcgactga

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