KEGG   Rattus norvegicus (rat): 292756Help
Entry
292756            CDS       R.norvegicus                           
Gene name Pak4
Definition p21 protein (Cdc42/Rac)-activated kinase 4 (EC:2.7.11.1)
Orthology K05734  p21-activated kinase 4 [EC:2.7.11.1]
Pathway rno04012  ErbB signaling pathway
rno04360  Axon guidance
rno04510  Focal adhesion
rno04660  T cell receptor signaling pathway
rno04810  Regulation of actin cytoskeleton
rno05211  Renal cell carcinoma
Class Metabolism; Enzyme Families; Protein kinases
Environmental Information Processing; Signal Transduction; ErbB
signaling pathway [PATH:rno04012]
Cellular Processes; Cell Motility; Regulation of actin cytoskeleton
[PATH:rno04810]
Cellular Processes; Cell Communication; Focal adhesion
[PATH:rno04510]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Development; Axon guidance [PATH:rno04360]
Human Diseases; Cancers; Renal cell carcinoma [PATH:rno05211]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: Pkinase Pkinase_Tyr PBD APH Kdo
PROSITE: PROTEIN_KINASE_ATP PRO_RICH CRIB PROTEIN_KINASE_DOM
Motif
Other DBs NCBI-GI: 157819679
NCBI-GeneID: 292756
RGD: 1307705
RATMAP: ENSRNOG00000019883
Ensembl: ENSRNOG00000019883
UniProt: B5DF62
Position 1q21
AA seq 593 aa AA seqDB search
MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLIDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRESPPPPARAHQENGMLEE
RAALARMAPDKAGGRGRATGHSEAGSGSGDRRRVGPEKRPKSSREGPGGPQEVSRDKRPL
SGPDVSTPQPGSLASETKLAAGRPFNTYPRADTDHPPRGTQGEPHTMAPNGPSAIGLAAP
QSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPARALAAPAVPPAPGPPGPRSPQREPQR
VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ
RRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA
AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT
PYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL
HKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLMRQHRNR
NT seq 1782 nt NT seq  +upstreamnt  +downstreamnt
atgtttggaaagaagaagaagcgggtggagatctcggccccatccaacttcgagcaccgc
gtacacacaggcttcgatcagcatgagcagaagttcacagggctgccccgccagtggcag
agcctgattgaggagtcagcgcgcagacccaagcccctgatcgaccctgcttgcatcact
tccatccagcctggagcccccaagaccatcgtgcggggcagcaaaggtgccaaggatggg
gctctcacactgctgcttgacgaatttgagaacatgtcggtgacacgctccaactccctg
cgcagagagagtcctccaccccctgcccgcgcccatcaggaaaatggaatgctggaggag
cgggcagctctggccagaatggcccctgacaaagctggaggcaggggccgggccacaggc
cacagtgaggcaggcagtggcagtggtgacagacggcgggtggggccagagaagaggccc
aagtcatcaagggagggcccaggagggccccaggaggtctcccgtgataagcgccccctc
tctggtcctgatgtcagcactcctcagcctggcagtctggccagcgagacaaaactagca
gctggcagaccctttaacacataccctcgggctgacacggaccacccaccccggggtacc
cagggggagccacacaccatggcccctaatgggccatcagccataggcctggctgctcct
cagtcttcctcctcctcccggcctcccacccgagcccgtggtgctcccagcccgggagtg
ctgggtccccatgcctctgagccccagttggcccccccagcacgtgcccttgctgcccct
gctgtaccccctgctcctgggccccctgggcctcggtcaccacagcgggagccccaacga
gtatcccatgagcagttccgggccgccctgcagctagtggtggacccaggggaccctcgt
tcctatctagacaacttcatcaagattggcgagggctctacaggtattgtgtgcatagcc
actgtgcgaagctcgggcaaactggtggccgtcaagaagatggacttgcgtaagcagcag
agacgtgagctgctcttcaatgaggtggtgatcatgagggactaccggcatgaaaacgtg
gtggagatgtacaacagctacctggtaggcgatgagctctgggtggtcatggagttcctg
gagggaggcgccctcacggatattgtcacccacaccaggatgaatgaggaacagattgcc
gccgtgtgcctggctgtgcttcaggcgctgtctgtgctccatgcccagggcgtcatccac
cgtgacatcaagagtgactccatcctgctgacccacgatggccgggtgaagctgtccgac
ttcgggttttgtgcccaggtgagcaaggaggtgcctcggaggaagtcgctggtgggcacc
ccatactggatggccccagagctcatctcccgccttccctacgggccagaggtggatatc
tggtcactgggggtaatggtgatcgagatggtggatggggaacccccctacttcaacgag
ccacccctgaaagccatgaagatgattcgggacaacctgccgccccgactgaagaacctg
cacaaggcctcaccatctctgaaaggcttcttggatcgcctgctggtgcgtgacccagcc
cagcgggccactgctgctgagctgctgaagcacccgttcctcaccaaggcggggccgcca
gccagcattgtgccccttatgcgccagcaccgaaacagatga
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