KEGG   Rattus norvegicus (rat): 29741Help
Entry
29741             CDS       R.norvegicus                           
Gene name Pik3r2
Definition phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Orthology K02649  phosphoinositide-3-kinase, regulatory subunit
Pathway rno04012  ErbB signaling pathway
rno04062  Chemokine signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04150  mTOR signaling pathway
rno04210  Apoptosis
rno04370  VEGF signaling pathway
rno04510  Focal adhesion
rno04620  Toll-like receptor signaling pathway
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04930  Type II diabetes mellitus
rno04960  Aldosterone-regulated sodium reabsorption
rno05200  Pathways in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
Class Environmental Information Processing; Signal Transduction; ErbB
signaling pathway [PATH:rno04012]
Environmental Information Processing; Signal Transduction; VEGF
signaling pathway [PATH:rno04370]
Environmental Information Processing; Signal Transduction; Jak-STAT
signaling pathway [PATH:rno04630]
Environmental Information Processing; Signal Transduction;
Phosphatidylinositol signaling system [PATH:rno04070]
Environmental Information Processing; Signal Transduction; mTOR
signaling pathway [PATH:rno04150]
Cellular Processes; Cell Motility; Regulation of actin cytoskeleton
[PATH:rno04810]
Cellular Processes; Cell Growth and Death; Apoptosis [PATH:rno04210]
Cellular Processes; Cell Communication; Focal adhesion
[PATH:rno04510]
Organismal Systems; Immune System; Toll-like receptor signaling
pathway [PATH:rno04620]
Organismal Systems; Immune System; Natural killer cell mediated
cytotoxicity [PATH:rno04650]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Immune System; B cell receptor signaling pathway
[PATH:rno04662]
Organismal Systems; Immune System; Fc epsilon RI signaling pathway
[PATH:rno04664]
Organismal Systems; Immune System; Fc gamma R-mediated phagocytosis
[PATH:rno04666]
Organismal Systems; Immune System; Leukocyte transendothelial
migration [PATH:rno04670]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; Progesterone-mediated oocyte
maturation [PATH:rno04914]
Organismal Systems; Excretory System; Aldosterone-regulated sodium
reabsorption [PATH:rno04960]
Organismal Systems; Nervous System; Neurotrophin signaling pathway
[PATH:rno04722]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Colorectal cancer [PATH:rno05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:rno05212]
Human Diseases; Cancers; Glioma [PATH:rno05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:rno05220]
Human Diseases; Cancers; Melanoma [PATH:rno05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:rno05211]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Cancers; Endometrial cancer [PATH:rno05213]
Human Diseases; Cancers; Small cell lung cancer [PATH:rno05222]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:rno05223]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:rno04930]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: SH2 RhoGAP SH3_1 Hydantoinase_A
PROSITE: SH2 SH3 RHOGAP
Motif
Other DBs NCBI-GI: 59709464
NCBI-GeneID: 29741
RGD: 68341
RATMAP: ENSRNOG00000019228
Ensembl: ENSRNOG00000019228
UniProt: Q5FVS6
Position 16p14
AA seq 722 aa AA seqDB search
MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSESGHTLASLAEQFSP
PEPAPPILVKLIEAIEQAELDSECYSRPELPAPRTDWSLSDLEQWDRTTLYDAVKGFLLA
LPAAVVTPEAASEAYRAMREVTGPVGLVLEPPTLPLHQALTLQFLLQHLGRVARRAPSPA
TAVHALASAFGPLLLRAPPPGGEGDGSEPAPDFPVLLLERLVQEHVDEQDTAPPALPPKP
SKVKPAPTALANGGSTPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYT
LTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVS
KYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNE
TIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDL
RAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYS
LMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTK
HCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPA
AR
NT seq 2169 nt NT seq  +upstreamnt  +downstreamnt
atggcaggtgctgaaggcttccagtacagggctgtatacccattccgccgggagcggcct
gaggacctggagcttcttcctggtgacctcctggtggtgagccgggtggctctgcaggca
ctaggtgtggctgatggaggagagcgctgcccacacaacgtgggctggatgcctggcttc
aatgagcgcacccgacagcgaggggacttccctggaacatatgtggagttcctaggacct
gtggctctggctcgaccaggccctcgcccacgggggccccgtccgttgcctgccaggccc
ttggatggaccttctgagtcaggtcacacactggcaagcctggcagagcagttctcccca
cctgagcctgcgcccccgattctggtgaagctgatagaagccattgagcaagcagagctg
gacagtgaatgctacagtaggccggagctgcccgcaccacggacagactggtccctgagt
gacttggagcagtgggaccgcaccaccttgtacgatgctgttaagggcttcctgctggca
ttgcctgcagctgtggtgactcctgaggctgcatcggaggcttatcgggcgatgcgggag
gttacggggcctgtggggctggtgctggaacccccaacgctgccgttgcaccaggccctc
actctgcagttcctgctgcagcacctgggccgcgtggcccgcagagcaccctcaccagct
acagctgtccacgcactggccagtgccttcgggccgctgctgctgcgtgcgcctccgcca
gggggcgagggtgatgggagtgagcctgcacctgacttccctgtgctgcttctagagagg
ctggtgcaggagcatgtggatgagcaagacaccgccccgccagcactgccacccaaaccc
tctaaggtaaagccggcacccacagccctggccaatggagggagtacaccctcgcttcag
gatgcagagtggtactggggggacatttccagggaagaggtgaatgagaggctccgagac
acacctgatggtaccttcttagtccgagatgcatccagcaagatccaaggagagtacacg
ctcaccctcaggaaaggcgggaacaacaagctaatcaaagtcttccaccgggacggtcac
tatggcttctcagagccccttaccttctgctccgtggtagagctcatctcccactaccga
catgagtcactggcccagtacaacgccaagctggacacgcgccttctctaccctgtgtcc
aagtaccagcaagaccaggtggtgaaggaggacagtgtagaggctgtgggtgcccagctc
aaggtctaccaccagcagtaccaggacaagagccgcgagtatgaccagctctatgaggaa
tacacacgaacctcccaggagcttcagatgaagcgcacagccatagaggccttcaacgag
accatcaagatcttcgaagaacagggccagacacaggaaaagtgcagcaaggagtatttg
gagcgcttccggcgagagggcaatgagaaggagatgcagaggatcctgctgaactcggag
cgactcaagtctcgaatcgcggagatacatgaaagccgcacgaagctggagcaggatctg
cgggcgcaggcctcggacaatcgagagattgacaagcgcatgaacagcctcaagcctgat
ctcatgcagctgcgcaagatcagggaccagtacctcgtgtggctcacccagaaaggtgcc
cgacagaggaagatcaacgagtggctgggaatcaagaatgagactgaggaccagtattca
ctgatggaggatgaggacgccctcccccaccatgaggagcgcacgtggtacgtgggcaag
atcaaccgcacacaggcggaggagatgctgagtggcaaacgagacgggaccttcctcatc
cgggagagcagccagcggggctgttacgcatgctctgtggtggtggatggcgacacgaag
cactgtgtcatctaccgcacagccactggctttggcttcgcagagccctataacctgtac
ggatccctgaaggagctggtattgcactaccagcacgcatcacttgtgcagcacaatgac
gcgctcaccgtcaccctcgcacaccctgtgcgtgcccccgggcctggcccgccccctgca
gcacgctga
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