KEGG   Rattus norvegicus (rat): 298947Help
Entry
298947            CDS       T01003                                 

Gene name
Pik3cg, Pi3k
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    298947 (Pik3cg)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    298947 (Pik3cg)
   04015 Rap1 signaling pathway
    298947 (Pik3cg)
   04012 ErbB signaling pathway
    298947 (Pik3cg)
   04370 VEGF signaling pathway
    298947 (Pik3cg)
   04630 Jak-STAT signaling pathway
    298947 (Pik3cg)
   04668 TNF signaling pathway
    298947 (Pik3cg)
   04066 HIF-1 signaling pathway
    298947 (Pik3cg)
   04068 FoxO signaling pathway
    298947 (Pik3cg)
   04070 Phosphatidylinositol signaling system
    298947 (Pik3cg)
   04024 cAMP signaling pathway
    298947 (Pik3cg)
   04022 cGMP - PKG signaling pathway
    298947 (Pik3cg)
   04151 PI3K-Akt signaling pathway
    298947 (Pik3cg)
   04152 AMPK signaling pathway
    298947 (Pik3cg)
   04150 mTOR signaling pathway
    298947 (Pik3cg)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    298947 (Pik3cg)
  Cell growth and death
   04210 Apoptosis
    298947 (Pik3cg)
  Cell communication
   04510 Focal adhesion
    298947 (Pik3cg)
 Organismal Systems
  Immune system
   04611 Platelet activation
    298947 (Pik3cg)
   04620 Toll-like receptor signaling pathway
    298947 (Pik3cg)
   04650 Natural killer cell mediated cytotoxicity
    298947 (Pik3cg)
   04660 T cell receptor signaling pathway
    298947 (Pik3cg)
   04662 B cell receptor signaling pathway
    298947 (Pik3cg)
   04664 Fc epsilon RI signaling pathway
    298947 (Pik3cg)
   04666 Fc gamma R-mediated phagocytosis
    298947 (Pik3cg)
   04670 Leukocyte transendothelial migration
    298947 (Pik3cg)
   04062 Chemokine signaling pathway
    298947 (Pik3cg)
  Endocrine system
   04910 Insulin signaling pathway
    298947 (Pik3cg)
   04915 Estrogen signaling pathway
    298947 (Pik3cg)
   04914 Progesterone-mediated oocyte maturation
    298947 (Pik3cg)
   04917 Prolactin signaling pathway
    298947 (Pik3cg)
   04921 Oxytocin signaling pathway
    298947 (Pik3cg)
   04919 Thyroid hormone signaling pathway
    298947 (Pik3cg)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    298947 (Pik3cg)
  Digestive system
   04973 Carbohydrate digestion and absorption
    298947 (Pik3cg)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    298947 (Pik3cg)
  Nervous system
   04725 Cholinergic synapse
    298947 (Pik3cg)
   04722 Neurotrophin signaling pathway
    298947 (Pik3cg)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    298947 (Pik3cg)
  Development
   04380 Osteoclast differentiation
    298947 (Pik3cg)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    298947 (Pik3cg)
   05205 Proteoglycans in cancer
    298947 (Pik3cg)
   05203 Viral carcinogenesis
    298947 (Pik3cg)
   05210 Colorectal cancer
    298947 (Pik3cg)
   05212 Pancreatic cancer
    298947 (Pik3cg)
   05214 Glioma
    298947 (Pik3cg)
   05221 Acute myeloid leukemia
    298947 (Pik3cg)
   05220 Chronic myeloid leukemia
    298947 (Pik3cg)
   05218 Melanoma
    298947 (Pik3cg)
   05211 Renal cell carcinoma
    298947 (Pik3cg)
   05215 Prostate cancer
    298947 (Pik3cg)
   05213 Endometrial cancer
    298947 (Pik3cg)
   05222 Small cell lung cancer
    298947 (Pik3cg)
   05223 Non-small cell lung cancer
    298947 (Pik3cg)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    298947 (Pik3cg)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    298947 (Pik3cg)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    298947 (Pik3cg)
   05166 HTLV-I infection
    298947 (Pik3cg)
   05162 Measles
    298947 (Pik3cg)
   05164 Influenza A
    298947 (Pik3cg)
   05161 Hepatitis B
    298947 (Pik3cg)
   05160 Hepatitis C
    298947 (Pik3cg)
   05169 Epstein-Barr virus infection
    298947 (Pik3cg)
   05146 Amoebiasis
    298947 (Pik3cg)
   05145 Toxoplasmosis
    298947 (Pik3cg)
   05142 Chagas disease (American trypanosomiasis)
    298947 (Pik3cg)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     298947 (Pik3cg)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
UniProt: 
Position
6q16
AA seq 1102 aa AA seqDB search
MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQRISKTPETALLH
VAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQKKGQWYEIYDRYQVVQTLD
CLRYWKMMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRL
VTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIVNNCIFIVIHRGTTSQTIKVSADDT
PDTILQSFFTKMAKKKSLMNIPESQSEQDFVLRVCGRDEYLVGETPLKNFQWVRQCLKNG
EEIHLVLDTPPDPALDEVRNEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKLFTEEVLWNVWLEFGIKI
KDLPKGALLNLQIYCCKTPSLSSKASVETPGSESKGKAQLLYYVNLLLIDHRFLLRHGGY
VLHMWQISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGKAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSSLP
ESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKRADPTVLSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWEAESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTG
AFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDVCVRAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALMVGRSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt
atggagctggagaactatgaacaacctgtggttctgagagaggacaacctccgcaggcgc
cggaggatgaagccacgcagcgcagcaggcagcctgtcttccatggagctcatccccatt
gagttcgtactgcccaccagccagcgcatcagcaagacaccggaaacggccctgctgcat
gtggctggccacggcaatgtggagcagatgaaagctcaggtgtggttacgcgcactggag
accagtgtggctgcggaattctaccaccgattaggtccggaccaattcctcctcctctac
cagaagaagggacagtggtatgagatctacgataggtaccaagtggtgcagaccctagac
tgcctacgttactggaagatgatgcacaagagccccggccagatccacgtggtacagcga
catgtaccttctgaggagaccctggctttccagaagcagctcacctccctgattggctac
gacgtcactgacatcagcaacgtgcacgatgatgagctagaattcactcgccgccgtctg
gttacgccccgcatggctgaagtggctggccgggatgccaaactctatgccatgcaccct
tgggtgacctccaaacctcttccagactacctgtcaaaaaaaattgtcaacaattgcatt
ttcattgtcatccatcgtggtaccaccagtcaaaccatcaaggtctccgcagatgatact
cctgacaccatccttcagagcttcttcaccaagatggccaagaagaagtccctaatgaat
atcccagaaagtcaaagtgagcaggattttgtgctgcgggtctgtggccgtgatgagtac
ctagtaggtgaaacgcccctcaaaaatttccagtgggtgaggcagtgcctcaagaacgga
gaggaaatacacctggtgctcgacacgcctccagacccggccctagatgaggtgaggaac
gaagaatggccgctggtggatgactgcactggagtcaccggctaccatgagcagctgacc
atccatggcaaggaccacgagagcgttttcacagtgtctttgtgggactgtgaccgaaag
ttcagggtcaagatcagaggcattgatatccctgtcttgcctcggaacaccgacctcact
gtttttgtggaagcaaatatccagcatgggcaacaagtcctctgccaaaggagaaccagc
cctaagctcttcacagaagaggtgctctggaatgtgtggctggagtttggcattaaaatc
aaagacttgcccaaaggggccctactgaacctacagatctactgctgcaaaaccccatca
ctgtccagtaaggcttccgtagagacgccaggctccgagtccaagggcaaagcccagctc
ctctattacgtgaacttgctgttgatagaccaccgcttcctcctccgccatgggggctac
gtgctccacatgtggcagatatctgggaaggcagaggaacagggcagcttcaatgccgac
aagctcacctccgcaaccaatcctgacaaggagaactcaatgtccatttccatcttgctg
gacaactactgtcaccccattgctttgcctaagcaccggcctactccggacccagaagga
gacagagttcgagctgaaatgcccaatcagcttcgaaagcaattggaggcaatcatagcc
acagatccacttaaccccctcacagcagaggacaaagaattgctctggcattttagatat
gaaagcctgaagcatccaaaggcataccctaaactattcagctcagtaaagtggggacag
caagaaattgttgccaaaacataccagctattagccagaagggagatctgggatcaaagt
gctttggatgttggcttaaccatgcaactcctggactgcaacttttcagatgaaaacgta
agggccattgcagttcagaaactggagagcttggaggacgatgacgttttacattacctt
ctccagctggtgcaggctgtgaaatttgaaccataccatgacagtgcgctggccagattc
ttgctgaagcgtggcttgagaaacaagagaattggtcacttcttattctggttcttgcga
agtgagatagcccagtccagacactatcagcagaggttcgctgtgatcctggaagcgtac
ctgcgcggctgtggcaaggccatgctacaggacttcacgcagcaggtccacgtgattgag
atgttacagaaagtcaccattgatatcaaatcactctcggctgagaagtatgatgtcagt
tcccaagttatttcacagcttaagcaaaagcttgaaagcctgcagaattccagtcttcct
gagagctttagagttccctatgatcctggactgaaagcaggtaccctggtgattgagaag
tgtaaagtgatggcctccaagaagaagcccctgtggcttgagtttaaacgtgccgatcct
acagtcctatccaatgaaaccattgggatcatctttaaacatggcgacgatctacgccaa
gacatgttgatcttacagattctacgcatcatggagtccatttgggaggctgaatctctg
gacctgtgccttctgccttacggttgcatctcaactggtgacaaaatagggatgatagag
attgtgaaggacgccacgacgattgctcaaattcagcagagcacggtgggtaacacgggg
gcattcaaagatgaagtcctgaatcactggctcaaggaaaaatgccctattgaagaaaag
tttcaggcagcagtggaaaggttcgtttactcctgtgcaggctactgtgtggccacattt
gttcttgggataggtgacaggcacaacgacaacatcatgatctcagagacaggaaaccta
tttcacatagactttggacacattcttggcaattacaagagtttcctgggcatcaataaa
gagagagtaccttttgtcctaaccccggacttcttgtttgtgatgggaacttcgggcaaa
aagacaagtccacacttccagaaattccaggatgtctgcgttagggcttacctagctctt
cgccaccacacaaacctgctgatcatcctgttctccatgatgctgatgacaggaatgccg
cagctgacaagcaaagaggacattgaatacatccgggatgccctcatggtggggagaagc
gaggaggacgccaagaagtatttccttgatcagattgaagtctgcagggacaaaggatgg
actgtgcagtttaactggttcctccatcttgttcttggcatcaagcaaggagagaaacac
tccgcttga

DBGET integrated database retrieval system