KEGG   Rattus norvegicus (rat): 309361Help
Entry
309361            CDS       R.norvegicus                           
Gene name Chuk
Definition conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
Orthology K04467  inhibitor of nuclear factor kappa-B kinase alpha subunit
        [EC:2.7.11.10]
Pathway rno04010  MAPK signaling pathway
rno04062  Chemokine signaling pathway
rno04210  Apoptosis
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04920  Adipocytokine signaling pathway
rno05200  Pathways in cancer
rno05212  Pancreatic cancer
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
Class Metabolism; Enzyme Families; Protein kinases
Environmental Information Processing; Signal Transduction; MAPK
signaling pathway [PATH:rno04010]
Cellular Processes; Cell Growth and Death; Apoptosis [PATH:rno04210]
Organismal Systems; Immune System; Toll-like receptor signaling
pathway [PATH:rno04620]
Organismal Systems; Immune System; NOD-like receptor signaling
pathway [PATH:rno04621]
Organismal Systems; Immune System; RIG-I-like receptor signaling
pathway [PATH:rno04622]
Organismal Systems; Immune System; Cytosolic DNA-sensing pathway
[PATH:rno04623]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Immune System; B cell receptor signaling pathway
[PATH:rno04662]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Endocrine System; Adipocytokine signaling
pathway [PATH:rno04920]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Pancreatic cancer [PATH:rno05212]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:rno05220]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Cancers; Small cell lung cancer [PATH:rno05222]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: Pkinase Pkinase_Tyr IKKbetaNEMObind Kdo YrbL-PhoP_reg APH
PROSITE: PROTEIN_KINASE_ST PROTEIN_KINASE_ATP PROTEIN_KINASE_DOM
Motif
Other DBs NCBI-GI: 157821211
NCBI-GeneID: 309361
RGD: 1306661
RATMAP: ENSRNOG00000022485
Ensembl: ENSRNOG00000022485
Position 1q54
AA seq 745 aa AA seqDB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNNLCSLIVEPMESWLQLMLNWDPQQRGGPIDPPLKQPKC
FVLMDNILNLKIVHILNMTSAKIISFLLPYDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPV
TQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGTVTPPVSAWLPPTLADREHPLTCVVTPQDGETLAQMIEENLNCLGHL
STIIREANEDQSSSMMSLDWSWLAE
NT seq 2238 nt NT seq  +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggcctggcgccggcggcccctgggagatgcgggagagg
cttggcaccggcggcttcgggaacgtcagtctgtaccagcaccgggaacttgatctcaaa
atagcaattaagtcttgtcgcttagagctaagtaccaaaaacagagaacgatggtgccat
gaaatccagatcatgaaaaagttgaaccatgcaaatgttgtaaaggcctgtgatgttcct
gaggaattgaattttttaattaacgatgtgcctcttctagcaatggagtactgttctgga
ggggacctccggaagctactcaacaaaccagaaaattgttgtggacttaaagagagccag
atcctttctttactgagtgacataggatctgggattcgttatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaatatagtgcttcaagatgttggtgggaagataatg
cataaaataattgatttgggttatgccaaagatgtcgatcaaggaagtctctgtacatct
tttgtgggaacattacagtatttggccccagagctctttgaaaataagccatacacagcc
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgaaaagattaagaagaaagatccaaag
tgtatatttgcttgtgaagagatgaccggagaagttcggtttagtagccatttacctcag
ccaaacaacctttgtagtttaatagtagagccaatggaaagctggctacagttgatgctg
aattgggacccacagcagagagggggacctattgaccctcctttgaagcagccaaaatgc
tttgtgttaatggataacatcctcaacttgaagatagtgcacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatatgatgaaagtctccattcactacagtctcga
attgagcgtgaaacaggaataaatacaggttctcaagaacttctgtcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagtgagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgtgcaagacagcaagatacagcttccagtt
acacagcttcgcaaagtgtgggctgaagcagtgcactatgtatctgggctaaaggaggac
tacagcaggctctttcagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcgcaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgctgaaagcatggaaagaaatggaagaaaaggccattcac
tattctgaggttggtgtcattggataccttgaggatcaaattatgtctttgcacactgaa
atcatggagctgcagaagagcccctatgggagacgccagggagacctgatggaatccctg
gaacagcgtgccattgatctctataagcagctaaaacacagacccaccgatcactcctac
agtgacagcacggagatggtgaagatcattgtgcacactgtgcagagtcaggaccgagtt
ctcaaggagctgtttggtcacctgagcaagttgttgggctgcaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatttggcacctccttaaaattgcttgtacacag
agttctgctcgctctcttgtaggatccagtctagaaggcacagtaacccctccagtatca
gcatggctgccccctactctagcagaccgtgaacatcctctgacatgtgtggtaactcct
caagatggcgagacgttagcacaaatgatagaagaaaatctgaactgtcttggccattta
agtactattattcgtgaagcaaatgaggaccagagcagtagtatgatgagtcttgattgg
agttggttagcagaatga
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