KEGG   Rattus norvegicus (rat): 309757Help
Entry
309757            CDS       T01003                                 

Gene name
Sirt1, Sir2
Definition
(RefSeq) sirtuin 1
  KO
K11411  
NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
FoxO signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    309757 (Sirt1)
   04152 AMPK signaling pathway
    309757 (Sirt1)
 Organismal Systems
  Endocrine system
   04922 Glucagon signaling pathway
    309757 (Sirt1)
  Aging
   04211 Longevity regulating pathway - mammal
    309757 (Sirt1)
   04213 Longevity regulating pathway - multiple species
    309757 (Sirt1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    309757 (Sirt1)
  Substance dependence
   05031 Amphetamine addiction
    309757 (Sirt1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     309757 (Sirt1)
Chromosome [BR:rno03036]
 Eukaryotic Type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     309757 (Sirt1)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    309757 (Sirt1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
RGD: 
Position
20p11
AA seq 444 aa AA seqDB search
MCLCSGRKAILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCH
GSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFH
RAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCD
VIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPER
TVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVG
SSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDD
ALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEA
VNEAIAMKQELTDVNCTPDKSEHY
NT seq 1335 nt NT seq  +upstreamnt  +downstreamnt
atgtgcctgtgcagtggaaggaaagcaattttggaaatatatcccggacagttccagcca
tctctgtgtcacaaattcatagctttgtcagataaggaaggaaaactacttcgaaattat
actcaaaatatagataccttggagcaggttgcaggaatccaaaggatcattcagtgtcat
ggttcctttgcaacagcatcttgcctgatttgtaaatacaaagttgattgtgaagctgtt
cgtggagatatttttaatcaggtagttcctcggtgtcctaggtgcccagctgatgagcca
cttgccatcatgaagccagagattgtcttctttggtgaaaacttaccagaacagtttcat
agagccatgaagtatgacaaagatgaagttgacctcctcattgttattgggtcttctctg
aaagtaagaccagtagcactaattccaagttctataccccatgaagtgcctcaaatatta
ataaatagggaacctctgcctcatctacattttgatgtagagcttcttggagactgcgat
gtcataattaatgagttgtgtcataggttaggtggcgagtatgccaaactttgttgtaac
cctgtaaagctttcagaaattactgaaaaacctccacgaacacaaaaggaattggttcat
ttatcagagttgccaccaacacctcttcatatttcagaagactcaagttcacctgaaaga
actgtaccacaagactcttctgtgattgctacacttgtagaccaaacaataaagaacaaa
gttgacgatttagaagtatctgaaccaaaaagttgtgtggaagaaaaatcacaggaagta
cagacttataggaatgttgagagcattaatgtggaaaacccagatttcaaggctgttggt
tccagtactggagacaaaaatgaaagaacttctgttgcagaaacagtgagaaaatgctgg
cctaatagacttgcaaaggagcagattagtaagcgtcttgacggtaatcaatacttgttt
gtaccaccaaatcgttacatatttcatggtgctgaggtatactcagactctgaagatgac
gccttatcctctagttcctgtggcagtaacagtgacagtggcacatgccagagtccaagt
ttagaagaacccttggaagatgaaagtgaaattgaagagttctacaatggcttggaagat
gatgctgacagaccggagtgtgctggaggatctggagctgacggaggggatcaagaggca
gttaatgaagctatagccatgaaacaggaattaacagatgtaaactgtacaccagacaaa
tcagagcactattga

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