KEGG   Rattus norvegicus (rat): 309757Help
Entry
309757            CDS       T01003                                 

Gene name
Sirt1, Sir2
Definition
(RefSeq) sirtuin 1
  KO
K11411  
NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
FoxO signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    309757 (Sirt1)
   04152 AMPK signaling pathway
    309757 (Sirt1)
 Organismal Systems
  Endocrine system
   04922 Glucagon signaling pathway
    309757 (Sirt1)
  Aging
   04211 Longevity regulating pathway - mammal
    309757 (Sirt1)
   04213 Longevity regulating pathway - multiple species
    309757 (Sirt1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    309757 (Sirt1)
  Substance dependence
   05031 Amphetamine addiction
    309757 (Sirt1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     309757 (Sirt1)
Chromosome [BR:rno03036]
 Eukaryotic Type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     309757 (Sirt1)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    309757 (Sirt1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
RGD: 
Position
20p11
AA seq 555 aa AA seqDB search
MIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQE
CKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKF
AKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCL
ICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDE
VDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHR
LGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVI
ATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVGSSTGDKNER
TSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGS
NSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQ
ELTDVNCTPDKSEHY
NT seq 1668 nt NT seq  +upstreamnt  +downstreamnt
atgattggcaccgatcctcgaacaattcttaaagatttattaccagaaacaattcctcca
cctgagttggatgatatgacactgtggcagattgttattaatatcctttcagaaccacca
aagcggaaaaaaagaaaagatattaatacaattgaagatgctgtgaagttactacaagag
tgcaaaaagataatagttctgactggagctggggtttctgtttcctgtgggatacctgac
ttcagatcaagagatggtatttatgctcgccttgctgtggacttcccggatctcccagat
cctcaagccatgttcgatattgagtattttagaaaagacccaagaccattcttcaagttt
gcaaaggaaatatatcccggacagttccagccatctctgtgtcacaaattcatagctttg
tcagataaggaaggaaaactacttcgaaattatactcaaaatatagataccttggagcag
gttgcaggaatccaaaggatcattcagtgtcatggttcctttgcaacagcatcttgcctg
atttgtaaatacaaagttgattgtgaagctgttcgtggagatatttttaatcaggtagtt
cctcggtgtcctaggtgcccagctgatgagccacttgccatcatgaagccagagattgtc
ttctttggtgaaaacttaccagaacagtttcatagagccatgaagtatgacaaagatgaa
gttgacctcctcattgttattgggtcttctctgaaagtaagaccagtagcactaattcca
agttctataccccatgaagtgcctcaaatattaataaatagggaacctctgcctcatcta
cattttgatgtagagcttcttggagactgcgatgtcataattaatgagttgtgtcatagg
ttaggtggcgagtatgccaaactttgttgtaaccctgtaaagctttcagaaattactgaa
aaacctccacgaacacaaaaggaattggttcatttatcagagttgccaccaacacctctt
catatttcagaagactcaagttcacctgaaagaactgtaccacaagactcttctgtgatt
gctacacttgtagaccaaacaataaagaacaaagttgacgatttagaagtatctgaacca
aaaagttgtgtggaagaaaaatcacaggaagtacagacttataggaatgttgagagcatt
aatgtggaaaacccagatttcaaggctgttggttccagtactggagacaaaaatgaaaga
acttctgttgcagaaacagtgagaaaatgctggcctaatagacttgcaaaggagcagatt
agtaagcgtcttgacggtaatcaatacttgtttgtaccaccaaatcgttacatatttcat
ggtgctgaggtatactcagactctgaagatgacgccttatcctctagttcctgtggcagt
aacagtgacagtggcacatgccagagtccaagtttagaagaacccttggaagatgaaagt
gaaattgaagagttctacaatggcttggaagatgatgctgacagaccggagtgtgctgga
ggatctggagctgacggaggggatcaagaggcagttaatgaagctatagccatgaaacag
gaattaacagatgtaaactgtacaccagacaaatcagagcactattga

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