KEGG   Rattus norvegicus (rat): 313845Help
Entry
313845            CDS       T01003                                 

Gene name
Sos1
Definition
(RefSeq) SOS Ras/Rac guanine nucleotide exchange factor 1
  KO
K03099  son of sevenless
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04062  Chemokine signaling pathway
rno04068  FoxO signaling pathway
rno04072  Phospholipase D signaling pathway
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04510  Focal adhesion
rno04540  Gap junction
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04714  Thermogenesis
rno04722  Neurotrophin signaling pathway
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04926  Relaxin signaling pathway
rno05034  Alcoholism
rno05160  Hepatitis C
rno05165  Human papillomavirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    313845 (Sos1)
   04010 MAPK signaling pathway
    313845 (Sos1)
   04012 ErbB signaling pathway
    313845 (Sos1)
   04630 Jak-STAT signaling pathway
    313845 (Sos1)
   04068 FoxO signaling pathway
    313845 (Sos1)
   04072 Phospholipase D signaling pathway
    313845 (Sos1)
   04151 PI3K-Akt signaling pathway
    313845 (Sos1)
   04150 mTOR signaling pathway
    313845 (Sos1)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    313845 (Sos1)
   04540 Gap junction
    313845 (Sos1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    313845 (Sos1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    313845 (Sos1)
   04660 T cell receptor signaling pathway
    313845 (Sos1)
   04662 B cell receptor signaling pathway
    313845 (Sos1)
   04664 Fc epsilon RI signaling pathway
    313845 (Sos1)
   04062 Chemokine signaling pathway
    313845 (Sos1)
  Endocrine system
   04910 Insulin signaling pathway
    313845 (Sos1)
   04912 GnRH signaling pathway
    313845 (Sos1)
   04915 Estrogen signaling pathway
    313845 (Sos1)
   04917 Prolactin signaling pathway
    313845 (Sos1)
   04926 Relaxin signaling pathway
    313845 (Sos1)
  Nervous system
   04722 Neurotrophin signaling pathway
    313845 (Sos1)
  Environmental adaptation
   04714 Thermogenesis
    313845 (Sos1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    313845 (Sos1)
   05231 Choline metabolism in cancer
    313845 (Sos1)
   05206 MicroRNAs in cancer
    313845 (Sos1)
   05205 Proteoglycans in cancer
    313845 (Sos1)
   05210 Colorectal cancer
    313845 (Sos1)
   05225 Hepatocellular carcinoma
    313845 (Sos1)
   05226 Gastric cancer
    313845 (Sos1)
   05214 Glioma
    313845 (Sos1)
   05221 Acute myeloid leukemia
    313845 (Sos1)
   05220 Chronic myeloid leukemia
    313845 (Sos1)
   05211 Renal cell carcinoma
    313845 (Sos1)
   05215 Prostate cancer
    313845 (Sos1)
   05213 Endometrial cancer
    313845 (Sos1)
   05224 Breast cancer
    313845 (Sos1)
   05223 Non-small cell lung cancer
    313845 (Sos1)
  Substance dependence
   05034 Alcoholism
    313845 (Sos1)
  Infectious diseases
   05160 Hepatitis C
    313845 (Sos1)
   05165 Human papillomavirus infection
    313845 (Sos1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    313845 (Sos1)
   01522 Endocrine resistance
    313845 (Sos1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RasGEF RasGEF_N RhoGEF Histone PH IQ_SEC7_PH PH_10 PH_13
Motif
Other DBs
NCBI-GeneID: 313845
NCBI-ProteinID: NP_001094186
RGD: 1310949
Ensembl: ENSRNOG00000007106
UniProt: D4A3T0
Position
6q11
AA seq 1319 aa AA seqDB search
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNEDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSY
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DVLRPGFHERFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECMKQAITALLNVQSGMEKICSKNLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEHMRLPSADVYRFAEPDSEENILFEENVQPKAGIPI
IKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDVDLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSK
RRRVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASSASSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTEEVPVPPPVP
PRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLL
PPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLP
SPPLTQEVDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS
NT seq 3960 nt NT seq  +upstreamnt  +downstreamnt
atgcaggcgcagcagctgccctacgagtttttcagcgaggagaacgcgcccaagtggcgg
gggctgctggtgcctgcgctgaaaaaggttcaggggcaagttcaccctactcttgagtct
aatgaggatgctcttcagtatgttgaagaattaattttgcaattactaaatatgctatgc
caagctcagccccggagtgcttcagatgtggaggaacgtgttcaaaaaagtttccctcat
ccaattgataagtgggcaatagctgatgcccaatcagctattgaaaagaggaagagaagg
aaccctttatccctgccagcagaaagaattcatcatttattaagggaggtcctgggttat
aaaattgaccaccaggtttctgtttacatagtagcagtattagaatacatttctgcagat
attttaaagctggtggggaattatgtaagaaatatacggcattatgaaattacaaaacaa
gacattaaagtggcaatgtgtgctgataaggtattgatggatatgtttcatcaagatgta
gaagatataaatatcttatctttaactgatgaagaaccttccacctcaggagaacaaact
tactatgatttggtaaaagcattcatggcagaaattcgacaatatataagagaattaaat
ctaattataaaggtttttcgagaaccctttgtctctaattccaagttgttttcatcttat
gatgtagaaaacatatttagtcgtatagtggatatccatgaacttagtgtaaagttactg
ggccatatagaagacactgtagagatgacagatgaaggcagtccccacccgttagtcgga
agctgttttgaagacttagcagaagaactggcctttgacccatatgagtcctatgctcgg
gatgttctgcggcccggattccatgagcgttttctcagtcagctatcaaagcctggggca
gcactttatctgcagtccataggtgaaggcttcaaagaggccgttcagtatgtcctgccc
cggctgctgctcgcccctgtgtaccactgtctgcattactttgaacttctgaagcagtta
gaagaaaagagcgaagatcaagaagataaggagtgtatgaaacaagcaataacagccctg
cttaatgtccaaagtggcatggaaaaaatttgctccaaaaatcttgcaaaacgaagactg
agtgagtctgcatgtcggttttacagccagcaaatgaaggggaaacaactggccatcaag
aagatgaatgagattcagaagaacattgatggttgggaggggaaagacattggacaatgc
tgcaatgagtttataatggaaggaactcttacacgtgtaggagccaaacacgagagacac
atatttctcttcgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagaatatcggcttaaagaaaagttttttatgcgaaaggtacag
attaacgataaggatgacaccagtgaatacaagcacgctttcgaaataattctgaaggat
ggaaatagtgttatattttctgccaagtcagctgaagagaagaataactggatggcagcc
ctgatatccctgcagtaccgcagcacgctggagagaatgctggacgttacaatgctgcag
gaggagaaggaggagcacatgaggctgccgagtgctgacgtgtacaggtttgcagagccc
gactctgaggagaacattctgtttgaagagaacgtgcagcccaaggctggcatccccatc
atcaaggcagggacagtggttaagctgattgagaggctcacgtaccacatgtacgcagat
ccaaattttgttcggacatttcttacaacatacagatcattttgcaaacctcaagaacta
ctgaatcttctaatagaaagatttgaaattccagagcctgagccaacagaagctgatcgc
atagctatagagaatggagatcagcccctgagcgcagagctgaaaaggtttagaaaggag
tatatccagcctgtacagctgagggtgttaaacgtgtgtcggcactgggtggagcaccat
ttctatgactttgaaagagatgtagaccttttacagagaatggaggaatttattggaaca
gtaagaggtaaagcaatgaaaaaatgggtcgaatccatcactaagataatccaaaggaaa
aaaattgcaagagacaatggcccaggtcataatattacatttcagaattcacctcccaca
gttgagtggcacataagcagacctgggcatatagagacttttgacttgctcaccctacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctataccgagctgtgcag
ccatcagaattagttggaagtgtgtggacaaaagaagataaagaaattaactctcctaac
cttctgaaaatgattcggcacaccaccaacctcactctgtggtttgagaaatgtattgta
gaaacagagaacttagaagaaagagtagcagtagtgagtcgaataattgagattctacaa
gtctttcaagagctgaacaacttcaatggtgtcctggaagttgttagtgctatgaactcg
tcacctgtttacagactggaccacacatttgagcaaataccaagtagacaaaagaaaatt
ttagaagaagctcatgagttgagtgaagatcactataagaaatatttggcaaaactcagg
tctattaatccaccatgtgtgcctttctttggaatttatctcacaaatatcttgaaaaca
gaagaaggcaaccctgaggtcctaagaagacatggaaaagagcttatcaacttcagcaag
aggaggagagtggccgagataacaggagagatccagcagtaccaaaaccagccttactgc
ttacgggtagagtcagacatcaagagattctttgaaaacttgaatccaatgggaaatagc
atggagaaggaatttacagactatctattcaacaaatccctagaaatagaaccacggaac
cctaagcctcttccaagatttccaaaaaaatacagctatcccctaaaatctcctggtgtt
cgtccatcaaatccaagaccaggaaccatgaggcaccctacacctctgcagcaggagcca
aggaaaatcagctacagtcggattcctgagagcgagacagaaagtacagcgtcggcacca
aactccccgagaacaccgctgacgccgcctcctgcgtccagcgcctccagtaacacagac
gtctgcagcgtgttcgattccgaccactccgcaagcccttttcactcaagatctgcttca
gtctcatctataagtttatccaagggcaccgaggaagtgcctgtccctcctcctgtcccc
cctcgaagacgaccagagtctgccccagcggaatcctccccatccaagattatgtctaag
cacttggatagccccccagcgattcctcctaggcagcccacatcgaaagcctattcacca
cgatactcaatatcagatcggacctctatatcagatcctcccgagagccctcccttgtta
ccaccacgagaacctgtgaggacacccgatgttttctcaagctcgccattacatctccaa
cctcccccgttgggcaaaaagagtgaccatggcaatgccttcttcccaaacagcccatcc
ccctttacaccgccacctcctcaaaccccgtctcctcacggcacgagaaggcatctgcca
tcaccaccactgacacaggaagtggacctccattccattgctgggcctcccgttcctcca
cggcaaagcacttctcaacttatccccaaactccctccaaaaacttacaaaagggagcac
acacacccatccatgcacagagatggaccgccactgctggagaatgcccattcttcctga

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