KEGG R.norvegicus: 315350

Rattus norvegicus (rat): 315350

Entry

315350 CDS R.norvegicus

Gene name Irs4, Irs4_predicted

Definition insulin receptor substrate 4

Orthology K07187 insulin receptor substrate

Pathway rno04722 Neurotrophin signaling pathway
rno04910 Insulin signaling pathway
rno04920 Adipocytokine signaling pathway
rno04930 Type II diabetes mellitus
rno04960 Aldosterone-regulated sodium reabsorption

Class Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; Adipocytokine signaling
pathway [PATH:rno04920]
Organismal Systems; Excretory System; Aldosterone-regulated sodium
reabsorption [PATH:rno04960]
Organismal Systems; Nervous System; Neurotrophin signaling pathway
[PATH:rno04722]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:rno04930]

SSDB

Motif Pfam: IRS PH
PROSITE: ALA_RICH ARG_RICH GLY_RICH NLS_BP PH_DOMAIN IRS_PTB

Other DBs NCBI-GI: 109512418
NCBI-GeneID: 315350
RGD: 1562442

Position Xq14

AA seq 1405 aa
MGRLILEHVDDVNEWVIDGSNIYFARIESSNVGQLSNSVNFEGIAVIPESLESLAFVRGG
EGEEACAAWCAAWCAADGPASLAPGSHPTHTSTGGRLRPSSAGVRAASGASSRVRRRSRV
VLPTAVSPVKWAGTRAWAGGVWGGQTGGELPLLPRSPPFSSPPSPPLTLKPPCITMASCS
FAGDXALRRLRAAAAAASAALAAVATTPLLSSGTPTALIGTGSSCPGAMWLSPATGSRSD
SESDEEDLPVGDEVCKRGYLRKQKHGQRRYFVLKLETEDAPARLEYYQNARKFRLSVRAA
AAAAAAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMVAENES
EQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVVVKPRGLG
HRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPG
ELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISVGAHLLTLLSTRRHLGSLP
LEPGGWFRRSRFEQFCHLRAICHREDMLFTRRFIAPREPPPPFKRGRGHLPRARRSRRAV
SVPPSFPRRSAPSPGRIRQPEDARNHRACQASGSSSGNSEEKDKEGEEGNGGACMPMNNW
GSGNGRGSGGGQGSSGQGSSSQSSGGRQGSGGGQGSGGQGAGGNQRSGNGQGTAGGHGSG
GGGHGSGGGQGPGDGHGSGGGKNSGGSKGSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQQ
QQQQQTLPPPPPPPPAAGATGGKGKSGGRFRLYFCADRGTKERKEAKEVRNMETSQGTTR
GSLRARALYEDEDDPYVPMRPGVAAPLACSSDYMPMAPQNSSAPTKRHSKSPFEDSRGYM
MMFPRVSPPPPAPSARKAPDTHKEDDSKDNDSDSDYMFMAPGAGAIPKNPPNPQGGSSSK
SWSSYFSLPSPFQSSPLGQSNHSEYVPMLPGKFLGSSLDKHASFSQGTKDVASKPSTEGS
FSKPEDKGSSARPSDDVPPMNQAKEPNRLSFIAKGNKIKPRPLNPTQEQREADSSNDYIN
IDFVKREHLVLAPSAQGLPEFWGVITNARPSAFSRYVKVEFGAPFPNPTVRLSELLRVIP
GANPIPLAGARWPFRPFPGNAVGSILEGGEYIEVIFNPALTPAVPFADSAICYDTQTGQI
YVVDPFSECCMDASVSPSRYSEPPPVARQEEVQERRRPQSGSQSLFANTRAAVSAFPTDS
LDRDFPAASAVIAAPAGAPLLAVSRALAVASALAAAPSTGAVFVGFPVAAGDSASARWFQ
PVANAPGAQAEREVRDIAAGWNPGTLNQAANGEDLAAGAAAPPPPPRHHRVLRPPERADS
EDNYDDEDDDNIYVRMDFARRDYKK

NT seq 4218 nt +upstreamnt +downstreamnt
atgggtagactcatattggaacatgtagatgatgtgaatgaatgggtcattgatggcagc
aacatctattttgccagaattgaaagcagcaatgttggccagctgtccaatagcgttaat
tttgaaggcatcgccgtaattcctgagtctttagagtcgttggcttttgtcaggggtgga
gagggcgaggaggcatgtgcagcctggtgtgcagcctggtgtgccgcagatggccctgct
tccctggctcccggttcccatcccacgcacacctctactggtggccgcttgcgcccctcc
agtgctggggtgcgggctgcctctggtgcgagcagccgcgtgaggcgacggtcacgtgtt
gttttgcccactgctgtgagcccggtgaagtgggcggggacgcgggcctgggcgggaggg
gtctggggcgggcagacagggggagaactgcctcttctcccccgaagccctcccttctcg
agccccccctcccctccgctcaccttaaaaccaccgtgcatcaccatggcgagttgctcc
ttcgctggcgactaagcgctaaggagactgagagccgcagcagcagcagcctccgcagct
ctagcagcagtggcgaccaccccgcttctttcctcgggaaccccgaccgcactcattggg
accgggtcgtcctgtccgggagccatgtggctctccccagccactggctcccggtcagac
tccgagtccgacgaggaggacctccccgtcggggatgaagtctgcaaacgcggctacctg
cggaagcagaagcatgggcagaggcgttacttcgtgctcaaactcgagaccgaagacgct
ccggctcggctcgaatactaccaaaatgccaggaagttccggctcagtgtccgtgccgcg
gcggctgccgcagccgcggccgcctccggtgctgcggtccccgcgctcatcccaccgcgg
cgcgtgatcatcctgtaccaatgcttctccgtgagccagcgcgccgatgccaggtaccga
cacctcattgccctctttacccaggacgagtacttcgcgatggtggccgagaatgagtcg
gaacaagaaagctggtacttgctcctcagccgcctcatcctcgagagcaagcgccgccgc
tgcggcacgctaggcgcgcagccggacggggagccggcagccctggcggcggcagcggcg
gcggagccacccttctacaaagatgtgtggcaggtagtagtgaaacccagggggctgggg
cacagaaaagagctgagcggcgtgttccggctgtgtcttaccgacgaagaggtagtgttt
gtaaggctcaataccgaagtggccagcgtggtcgtccagctgctgagcattcgtcgctgt
gggcactcagagcagtacttcttcttggaagtcggcaggtccactgtcatcggtccaggg
gagctgtggatgcaggtggatgactccgtggtggcccaaaacatgcatgagttgtttctg
gagaagatgagagccttgtgcgcagacgaatacagagcccgctgccgcagctacagcatc
agtgttggcgcccacctgttaaccctgctgtccactaggaggcacctgggctcgctcccg
ctggagcccggcggctggttcagaagatcccgctttgagcagttttgccacctcagggct
atctgccacagggaagacatgctattcaccagacgcttcatcgcacccagagagcctccg
cctcccttcaagcgaggaagggggcacctgcccagagcccgcaggtccaggagagccgtg
tcagtacctcccagctttccccgacgctcagcacctagcccaggacgtatccgacagcct
gaagatgctcgcaaccaccgagcttgtcaagcctcgggttccagctctggcaactctgaa
gaaaaagacaaggaaggtgaggaaggaaacggaggtgcctgcatgcctatgaacaactgg
ggctcaggaaatggccggggctccggaggtggacagggctcaagtggccaaggctccagt
agccagagctcaggtgggagacagggatctggaggtggccagggctcaggaggccagggt
gctggaggaaaccagcgttcaggaaatggccagggcacagcaggtggccatggctcaggt
ggaggtggccatggttcaggtggtggccagggacccggagatggtcatggctcaggtggt
ggcaagaactcaggaggtagcaaaggctcaggaagtgggaaaaattctgacgatggtgac
cgtggaaaatctgtgaagaaaagatcctactttggtaaattcactcaaagcaagcagcag
cagcagcagcagcaaacgctgcctccacccccaccgccgccgccagcagctggagcaact
ggtggcaaagggaagtctggggggagattccgactttatttttgcgcagacagaggcaca
aaagaacgcaaagaagccaaagaggtgagaaatatggagacctcacaaggtacaacccgg
gggtctctcagagccagagctctctatgaagatgaggatgacccatatgtgccaatgagg
ccaggggtggctgctcctcttgcatgttccagcgattacatgccaatggctcctcaaaat
tcctctgctccaaccaagcgtcactctaagtcgccctttgaagactccagagggtacatg
atgatgtttcccagagtgagcccaccaccacctgctccaagtgctcggaaagcgccggat
actcataaagaggatgactcaaaggacaatgacagtgacagtgactacatgtttatggct
cctggagcaggtgcgattcctaaaaatccccccaatccccagggaggctcttcctccaaa
agctggagctcttacttctctctgccaagtcctttccagagttcgcctttgggacagagt
aaccatagcgagtatgttcccatgttacctggaaaattcctggggagcagtctagacaaa
cacgcctcctttagccagggcaccaaagatgtagcttcaaagccttcaactgaggggtca
ttctcaaaacctgaagataaggggtcgtctgcaaggccttcagatgatgtgcccccaatg
aaccaggctaaggaacctaaccgactttcttttattgcaaaaggaaataaaataaagccc
agaccactaaaccccacacaggagcagagagaagctgacagctccaatgactatatcaac
attgactttgttaagagagagcaccttgtgctagctccctctgctcaaggactgccagaa
ttctggggtgtaattactaatgccagacccagcgctttttctcgctacgtgaaggttgaa
ttcggggcgccctttccaaatccaacagtccgcctctcagagcttttaagagttatacca
ggtgccaatcccatccctctggccggtgctaggtggccctttcgtcctttcccaggcaat
gctgtaggtagcatcctggaagggggtgaatacattgaagtgattttcaatccagctctg
acaccagccgtgccttttgctgacagtgccatttgctatgacactcagacaggtcaaatt
tatgtagtcgacccattttctgagtgctgtatggacgcttctgtctctcccagtcgatac
tccgaaccaccacctgtagctaggcaggaagaagtgcaagagagaagacgcccacaaagc
ggctcccaaagtttatttgccaacactcgagccgctgtctcggctttccctactgacagc
ttggacagagactttcccgccgcttcagccgtgattgctgctccagctggagcgcccctc
ttggcagtgagccgggctttagcagtggcctctgcgctcgcagcggcccccagcactggc
gctgtctttgtcggcttcccagttgcggctggagactccgcctccgctcgctggttccaa
cctgttgctaatgctcctggtgcccaggccgaaagagaggtccgggacattgccgcaggc
tggaatcctggaacccttaaccaagctgccaacggtgaggacctggcggctggcgcagcc
gctcccccgccgccgcctcgccaccatcgggtgctgagacccccagagagagcggattct
gaggacaactatgacgatgaggatgacgacaacatttacgtgagaatggactttgccaga
cgtgactacaagaagtga

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   UNIGENE (1)   
   RGD-RNO (1)   
Protein sequence (5)   
   RefSeq(pep) (2)   
   IPI (3)   
Protein domain (8)   
   Pfam (2)   
   PROSITE (6)   
All databases (24)

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