| Entry |
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| Gene name |
Dot1l
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| Definition |
DOT1-like, histone H3 methyltransferase (S. cerevisiae) (EC:2.1.1.43)
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| Orthology |
| histone-lysine N-methyltransferase, H3 lysine-79 specific [EC: 2.1.1.43] |
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| Organism |
rno Rattus norvegicus (rat)
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| Pathway |
| Lysine degradation | | Transcriptional misregulation in cancer |
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| Class |
Metabolism; Amino acid metabolism; Lysine degradation [PATH: rno00310]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH: rno05202]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: RGD: Ensembl: UniProt: |
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| Position |
7q11
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| AA seq |
1549 aa  
MGEKLELRLKSPVGAEPAVYPWPLPVYVSVLAENPGDKHHDAAHEIIETIRWVCEEIPDL
KLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHIL
QQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVL
QVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRER
IANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIM
RVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKS
NATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRG
RPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPD
PLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLF
SHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELR
SQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQ
QELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSM
NGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTR
LSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLA
SPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSR
AERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGAL
ASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAAS
PRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSG
TRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSM
VSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPG
SEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISD
LGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGT
NPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLS
RRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFIS
AAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVA
GSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN |
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| NT seq |
4650 nt  +upstreamnt +downstreamnt
atgggcgagaagctggagctgaggctcaagtcgcctgtgggcgcggagcccgccgtctac
ccgtggccgctgccggtctacgtgagtgtacttgcggagaacccgggggacaagcaccat
gatgctgctcatgagattatcgagactatccgatgggtctgcgaggaaatcccagatctc
aagctggccatggagaactatgtcctgatcgactacgacaccaaaagttttgaaagcatg
cagaggctgtgtgacaaatataaccgggccattgacagcatccaccagctgtggaagggc
actacacagcccatgaagctcaatactcggccgtccaatgggctcctgcggcacatcctg
cagcaggtgtacaaccactctgtgaccgacccagagaagctcaacaactacgagcccttc
tcccccgaggtgtacggggagacctcctttgacctggtggcccagatgatcgatgagatc
aagatgaccgaggatgacctgtttgtagacctgggcagtggtgtggggcaggttgtcctt
caggttgcggcggccaccaactgcaaacatcactacggagtggagaaagcggacatccca
gccaagtacgcggagaccatggatcgagagttcaggaagtggatgaaatggtatggaaaa
aagcatgcagaatacacactggagcgaggtgacttcctctcagaggagtggagggaacgg
atcgccaacacgagtgttatatttgtgaataactttgcctttggtcctgaggtggatcac
cagctgaaggaacgattcgcaaacatgaaggaaggcggcagaatcgtatcctcaaagccc
tttgcccctctgaacttcaggatcaacagcaggaacttgagtgacattggcaccatcatg
cgtgtggtggagctgtcgcccctgaagggctctgtgtcatggactggcaagcctgtctcc
tactacctgcacaccattgaccgcaccatacttgaaaactatttttctagtctgaaaaat
ccaaaactcagggaggagcaggaggcagctaggcgcaggcagcagcgagagaacaagagc
aacgcgaccacacccaccaaagtccctgagagcaaggcagctgccaccgaggcccctgcg
gattctggtgctgaggaagaaaaatcaggtgtggccaccgtcaaaaagcaatctccctcc
aaagcccggaagaagaaactgaacaagaaagggagaaaaatggctggccggaagcgtggg
cgacccaagaaaatgagtgctgccagtgccgatcgcaagtccaagaagagccaaagcaca
ctggatctcctgcactctccgcccccagccccaccctcagcctcaccccaggatgcatac
agggccccccacagcccgttctaccagctacctccgagcacgccgctgcactcgcccgac
ccactgctagtggctcccaccccacccgcgctgcagaagctgttagagtccttcaagatc
cagtacctgcagttcctggcctacacgaagaccccgcagtacaaggccaacctgcagcag
cttctggaccaggagaaggagaagaacacacaactgctgggtacagcccagcagctcttc
agccattgccaggcacaaaaggaagagatccgcaggctgttccagcagaagctggatgag
ttgggcgtgaaggcactgacctacaatgacctgattcaggcccagaaggaaatctctgcc
cacaaccagcagctgcgggagcagtcggaacagctggagaaggacaacagcgagcttcgg
agccagagcctgcggctgctcagggcccggtgcgaagagctgaggcttgactggtccacc
ttgtccctggagaacctgcggaaagagaagcaggccctgcggagccagatctcagagaag
cagcggcactgcctagagctgcagatcagcatcgtggagctggagaagacccagcgccag
caggagctcctgcagttgaagtcctgtgtgccaccagatgacgctctgtccctgcacctg
cgtggcaagggtgccctgggccgcgagctggagtctgacgctgggcgcttgcgccttgag
ctggactgtgccaagctctccctcccacacctcagcagcatgagccctgagctgtccatg
aatggccatgccgccagctatgagctctgcggtgcagctagtcggccctcgtccaagcag
aacaccccccagtatctggcctcccccttggaccaggaggtcgtgccctgcacccctagc
cacagtggccggcctcggctggagaagctgtctggcctggctttgcctgactacacccgg
ttgtcaccggccaagattgtgttgaggcggcacctgagccaggaccacaccggggccagc
aaagcagctactagtgagccacaccctcggccagagcatgccaaggagaacagccttccc
taccagagccctggcttgtcgaacagcatgaagctcagcccccaggatccaccgctggcc
tccccggcaacctcacccctcacttccgagaggggtagtgagaagggtgtaaaggagcgt
gcctacagcagccatggggagaccatcaccagcctgcctgtcagcattccactcagcaca
gtacagcccaacaagctgcctgtcagcatcccgctagccagcgtggtgctgcccagccgt
gccgagagggcgaggagcactcccagccctgtgccccagcctcgagactcctcatccaca
cttgagaagcagattggtgcttccacccatggtgcagggggtgctgcggcaggaagcagg
agcctcactgtggcgcccacaggtttctatgctggttcggtggccatcagtggggctctg
gccagcagcccagcacctctggcctctggaatggaatctgctgtttttgaggagtcctct
ggccccagcagcctctttggcaccatggggtctcgcagcacaccgccacaacatccacct
ctcctgccgcagtctcgcaactcgggccctgcctctcctgcccaccagctcgcagccagt
ccccgcctgagtgtgaccacccagggctcactgccagacaccggcaaaggggagctgcct
gctgatcctgccttctcagacccagagagtgaagctaagaggaggattgtgttcagcatt
tcagctggtgccagctccaggcagtcgccttccaccaggcacagccccttgacctctggc
acccgtggggattgtgttcagagccatgggcaggacagtcgtaagcgtagcagaaggaag
cgtgcatcagctggaacgcctagcctcaccacgggtgtgtcccccaagcgccgagctctg
ccaaccgtcgctggcctctttacacagtcttcggggtcgcctctcaatctcacctccatg
gtcagcaacatcaaccagcccctggagatcacagccatctcatccccggagagctcactg
aagagctcccccacaccctaccaggaccatgaccagcctccagtgctcaggaaggagcgg
cccctgggcccaactaatggggcccactactctccgctgacgtcagatgaggagccaggc
tcggaggacgagcccagcagtgcccgaattgagagaaaaattgcaacaatctctttagaa
agcaaatctcccccgaagacactggaaaatggtggtggcttagtgggaaggaagccggtc
ccctcaggcgagcctgtcaacagcagcaaatggaagtccaccttctcacccatctccgac
ctcggcttggccaaggccatggacagtccgctacaggccagctctgcactgagccacagc
cccctcttctctttccggccgtccttggaggagcctgctgctgaggccaagccctccacc
cacccaaggaaaagttttgcgggctctctggctgcagctgaggggccaagccctggcacc
aaccctcccaacagcctggccttcagtgggggccttgctgcagacctcggtttacatagc
ttcaatgacggtgcttccctctcccacaagggcccggaggtggcgggcctgagcgcctcc
ctgagcttcccatcccagaggggcaaggacagtaccacagaggccaaccccttcctcagc
aggcggcagccggagggcctgggtggcctgaagggtgagggcaatgcaagcaaggagtca
ggagagagcctgcccctgtgtgggccctcagacaaggtctcactgccacacggcagcagg
gccagcaaaggccgtgaccgcgagctggacttcaagggcggccacaacctcttcatctct
gctgcagccgtgcctccaggtggcctccttggtggccctggtcttgtaactgtggcttcc
tctgcgggcagtgcgacaccctctgcccaggctccccggcctttcctgagcacctttgcc
cctgggccccagtttactctgggccccatgtccctgcaggccaacctgggctctgtggcc
ggctcctctgtgctgcagtccttgttcagcactgtgccagctgctgcaggcctggtgcat
gtgtcatccactgcgacccgactgaccaactcacacaccatgggcagcttctcctctggg
gtggccggcggaaccgttggaggtaattag |
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