KEGG   Rattus norvegicus (rat): 366508Help
Entry
366508            CDS       T01003                                 

Gene name
Pik3cd
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    366508 (Pik3cd)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    366508 (Pik3cd)
   04015 Rap1 signaling pathway
    366508 (Pik3cd)
   04012 ErbB signaling pathway
    366508 (Pik3cd)
   04370 VEGF signaling pathway
    366508 (Pik3cd)
   04630 Jak-STAT signaling pathway
    366508 (Pik3cd)
   04668 TNF signaling pathway
    366508 (Pik3cd)
   04066 HIF-1 signaling pathway
    366508 (Pik3cd)
   04068 FoxO signaling pathway
    366508 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    366508 (Pik3cd)
   04024 cAMP signaling pathway
    366508 (Pik3cd)
   04022 cGMP - PKG signaling pathway
    366508 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    366508 (Pik3cd)
   04152 AMPK signaling pathway
    366508 (Pik3cd)
   04150 mTOR signaling pathway
    366508 (Pik3cd)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    366508 (Pik3cd)
  Cell growth and death
   04210 Apoptosis
    366508 (Pik3cd)
  Cellular commiunity
   04510 Focal adhesion
    366508 (Pik3cd)
 Organismal Systems
  Immune system
   04611 Platelet activation
    366508 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    366508 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    366508 (Pik3cd)
   04660 T cell receptor signaling pathway
    366508 (Pik3cd)
   04662 B cell receptor signaling pathway
    366508 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    366508 (Pik3cd)
   04666 Fc gamma R-mediated phagocytosis
    366508 (Pik3cd)
   04670 Leukocyte transendothelial migration
    366508 (Pik3cd)
   04062 Chemokine signaling pathway
    366508 (Pik3cd)
  Endocrine system
   04910 Insulin signaling pathway
    366508 (Pik3cd)
   04915 Estrogen signaling pathway
    366508 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    366508 (Pik3cd)
   04917 Prolactin signaling pathway
    366508 (Pik3cd)
   04921 Oxytocin signaling pathway
    366508 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    366508 (Pik3cd)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    366508 (Pik3cd)
  Digestive system
   04973 Carbohydrate digestion and absorption
    366508 (Pik3cd)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    366508 (Pik3cd)
  Nervous system
   04725 Cholinergic synapse
    366508 (Pik3cd)
   04722 Neurotrophin signaling pathway
    366508 (Pik3cd)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    366508 (Pik3cd)
  Development
   04380 Osteoclast differentiation
    366508 (Pik3cd)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    366508 (Pik3cd)
   05205 Proteoglycans in cancer
    366508 (Pik3cd)
   05203 Viral carcinogenesis
    366508 (Pik3cd)
   05210 Colorectal cancer
    366508 (Pik3cd)
   05212 Pancreatic cancer
    366508 (Pik3cd)
   05214 Glioma
    366508 (Pik3cd)
   05221 Acute myeloid leukemia
    366508 (Pik3cd)
   05220 Chronic myeloid leukemia
    366508 (Pik3cd)
   05218 Melanoma
    366508 (Pik3cd)
   05211 Renal cell carcinoma
    366508 (Pik3cd)
   05215 Prostate cancer
    366508 (Pik3cd)
   05213 Endometrial cancer
    366508 (Pik3cd)
   05222 Small cell lung cancer
    366508 (Pik3cd)
   05223 Non-small cell lung cancer
    366508 (Pik3cd)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    366508 (Pik3cd)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    366508 (Pik3cd)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    366508 (Pik3cd)
   05166 HTLV-I infection
    366508 (Pik3cd)
   05162 Measles
    366508 (Pik3cd)
   05164 Influenza A
    366508 (Pik3cd)
   05161 Hepatitis B
    366508 (Pik3cd)
   05160 Hepatitis C
    366508 (Pik3cd)
   05169 Epstein-Barr virus infection
    366508 (Pik3cd)
   05146 Amoebiasis
    366508 (Pik3cd)
   05145 Toxoplasmosis
    366508 (Pik3cd)
   05142 Chagas disease (American trypanosomiasis)
    366508 (Pik3cd)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     366508 (Pik3cd)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
5q36
AA seq 944 aa AA seqDB search
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRA
GLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYA
LQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
VKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPEVAP
HPVYFPALEKILELGRHGERGRITEEEMLYLLCSWPELPVLSALELLDFSFPDCYVGSFA
IKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMH
VPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMH
MCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGI
IFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIAN
IQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS
DNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERF
RGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQTLWH
NT seq 2835 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggtagactgccccatggagttctggaccaaagaggagagccagagcgtg
gccgttgacttcttgctgcccacaggagtctacttgaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgctgtggcatcgtgcacagtatgagccgttcttccac
atgctcagtgaccccgaggcttatgtgttcacctgtgtgaaccagacagcggagcagcag
gagttggaggatgagcagcggaggctgtgtgacatccagcccttcctgcccgtgctgcgc
ctggtggcccgagagggggaccgcgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggtctccatgagtttgattccctgcgggacccggaagtaaacgacttccgc
actaagatgcgccagttttgcgaagaggccgcggctcaccgccagcagctgggctgggtg
gaatggctgcagtatagcttccccctgcagctggagccctcagccagaggttggcgggct
ggcttattgcatgtcagcaaccgacccctgctggtcaatgtgaagttcgagggcagtgag
gagagcttcaccttccaggtatccaccaaggacatgcccctcgcactgatggcctgtgcc
ctccgaaaaaaggccaccgtgttccggcagcctctggtggagaggcctgaggagtatgcc
ctgcaggtgaacgggaggcacgagtacctctacggcagctaccccctctgccactttcag
tacatctgtagctgcctgcacagcggactgactccccatctgaccatggtccactcctcc
tccatcctcgccatgagggatgagcagagcaaccctgccccccaggtgcagaagccacga
gtcaaacctcccccgatccctgccaagaagccctcctctgtgtccctgtggtccctggaa
cagccattctgcattgagctgattgagggccgcaaggtgaatgcggatgaaaggatgaag
ctggttgtgcaggccgggctcttccacggcaatgagatgctgtgcaagactgtgtcgagc
tcagaggtgaatgtgtgctcagagcccgtgtggaagcagcgactagaattcgacatcagc
atctgtgacctcccccgaatggcccggctctgctttgcactctatgctgtcgtggagaag
gctaagaaggcgcgctccacaaagaagaagtccaagaaggcggactgtcccatcgcttgg
gccaacctcatgctattcgactacaaagatcagctcaagacgggcgaacggtgcctctac
atgtggccctctgtcccagatgagaaaggggaactgatgaatcctgcgggtacagtacgt
ggtaaccccaacacagagagtgccgctgccctggtcatctacctacctgaggtggctccc
caccctgtgtacttccctgctctggagaagatcctggagctggggcgtcacggggagcgt
gggcgcatcacagaggaggagatgctctatttgctgtgctcctggcccgagcttcctgtg
ctgagcgccctggagcttctggactttagttttcctgactgctacgtgggttccttcgcc
atcaagtccctacggaagctgacggatgacgagcttttccagtaccttctgcagctggta
caagtactcaaatatgagtcctacctggactgcgagttgaccaaattcttgttgggccga
gccctggctaaccgcaagatcgggcacttcctgttctggcacctccgctctgagatgcat
gtaccgtccgtggccctgcgttttggcctcatcatggaagcctactgcagaggcagcacc
caccacatgaaggtgctgatgaagcagggggaggcactgagcaagcttaaggccctgaat
gactttgtgaaggcgagctcgcagaagaccaccaagccccagaccaaggagatgatgcat
atgtgtatgcgccaggagacttacatggaggcgctgtcccacctgcagtctcccctcgac
cccagcaccctgctggaggaagtctgtgtggagcagtgcaccttcatggactccaaaatg
aagccattgtggatcatgtacagcagcgagaaggcaggcggtgccggcagcgtgggcatc
atctttaagaacggggatgacctccgccaggacatgctgactctgcagatgatccagctc
atggacttcctatggaagcaggagggcctggacctgaggatgaccccctatggctgcctc
cccaccggagatcgcacaggcctcattgaggtggtcctccactcggacaccatcgccaac
atccagctgaataaaagcaacatggcagccacggctgcgttcaacaaggacgctctgctc
aactggctcaagtctaagaaccctggggaggctctggatcgggccattgaggaattcacc
ctctcctgtgctggctactgtgtggccacatatgtgctgggcatcggtgaccggcacagc
gataacatcatgatcagagagagtgggcagcttttccacattgactttggccactttctg
gggaacttcaagaccaagttcgggatcaaccgggagcgtgtccccttcattctcacctac
gactttgtccacgtgatccagcaggggaagactaacaacagtgagaaatttgaaaggttc
cgaggctactgtgaacgagcctacaccatcctgcggcgtcacgggctgcttttccttcat
ctcttcgccctcatgcgcgcagcaggtctgcctgagcttagctgctccaaagacatccag
actctctggcactag

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