KEGG   Rattus norvegicus (rat): 366508Help
Entry
366508            CDS       R.norvegicus                           
Gene name Pik3cd
Definition phosphatidylinositol 3-kinase catalytic delta polypeptide
(EC:2.7.1.153)
Orthology K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase
        [EC:2.7.1.153]
Pathway rno00562  Inositol phosphate metabolism
rno04012  ErbB signaling pathway
rno04062  Chemokine signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04150  mTOR signaling pathway
rno04210  Apoptosis
rno04370  VEGF signaling pathway
rno04510  Focal adhesion
rno04620  Toll-like receptor signaling pathway
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04930  Type II diabetes mellitus
rno04960  Aldosterone-regulated sodium reabsorption
rno05200  Pathways in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
Class Metabolism; Carbohydrate Metabolism; Inositol phosphate metabolism
[PATH:rno00562]
Environmental Information Processing; Signal Transduction; ErbB
signaling pathway [PATH:rno04012]
Environmental Information Processing; Signal Transduction; VEGF
signaling pathway [PATH:rno04370]
Environmental Information Processing; Signal Transduction; Jak-STAT
signaling pathway [PATH:rno04630]
Environmental Information Processing; Signal Transduction;
Phosphatidylinositol signaling system [PATH:rno04070]
Environmental Information Processing; Signal Transduction; mTOR
signaling pathway [PATH:rno04150]
Cellular Processes; Cell Motility; Regulation of actin cytoskeleton
[PATH:rno04810]
Cellular Processes; Cell Growth and Death; Apoptosis [PATH:rno04210]
Cellular Processes; Cell Communication; Focal adhesion
[PATH:rno04510]
Organismal Systems; Immune System; Toll-like receptor signaling
pathway [PATH:rno04620]
Organismal Systems; Immune System; Natural killer cell mediated
cytotoxicity [PATH:rno04650]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Immune System; B cell receptor signaling pathway
[PATH:rno04662]
Organismal Systems; Immune System; Fc epsilon RI signaling pathway
[PATH:rno04664]
Organismal Systems; Immune System; Fc gamma R-mediated phagocytosis
[PATH:rno04666]
Organismal Systems; Immune System; Leukocyte transendothelial
migration [PATH:rno04670]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; Progesterone-mediated oocyte
maturation [PATH:rno04914]
Organismal Systems; Excretory System; Aldosterone-regulated sodium
reabsorption [PATH:rno04960]
Organismal Systems; Nervous System; Neurotrophin signaling pathway
[PATH:rno04722]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Colorectal cancer [PATH:rno05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:rno05212]
Human Diseases; Cancers; Glioma [PATH:rno05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:rno05220]
Human Diseases; Cancers; Melanoma [PATH:rno05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:rno05211]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Cancers; Endometrial cancer [PATH:rno05213]
Human Diseases; Cancers; Small cell lung cancer [PATH:rno05222]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:rno05223]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:rno04930]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: PI3_PI4_kinase PI3Ka PI3K_C2 PI3K_p85B PI3K_rbd
PROSITE: PI3_4_KINASE_1 PI3_4_KINASE_2 PI3_4_KINASE_3
Motif
Other DBs NCBI-GI: 157822959
NCBI-GeneID: 366508
RGD: 1310990
RATMAP: ENSRNOG00000016846
Ensembl: ENSRNOG00000016846
Position 5q36
AA seq 944 aa AA seqDB search
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRA
GLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYA
LQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
VKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPEVAP
HPVYFPALEKILELGRHGERGRITEEEMLYLLCSWPELPVLSALELLDFSFPDCYVGSFA
IKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMH
VPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMH
MCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGI
IFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIAN
IQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS
DNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERF
RGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQTLWH
NT seq 2835 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggtagactgccccatggagttctggaccaaagaggagagccagagcgtg
gccgttgacttcttgctgcccacaggagtctacttgaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgctgtggcatcgtgcacagtatgagccgttcttccac
atgctcagtgaccccgaggcttatgtgttcacctgtgtgaaccagacagcggagcagcag
gagttggaggatgagcagcggaggctgtgtgacatccagcccttcctgcccgtgctgcgc
ctggtggcccgagagggggaccgcgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggtctccatgagtttgattccctgcgggacccggaagtaaacgacttccgc
actaagatgcgccagttttgcgaagaggccgcggctcaccgccagcagctgggctgggtg
gaatggctgcagtatagcttccccctgcagctggagccctcagccagaggttggcgggct
ggcttattgcatgtcagcaaccgacccctgctggtcaatgtgaagttcgagggcagtgag
gagagcttcaccttccaggtatccaccaaggacatgcccctcgcactgatggcctgtgcc
ctccgaaaaaaggccaccgtgttccggcagcctctggtggagaggcctgaggagtatgcc
ctgcaggtgaacgggaggcacgagtacctctacggcagctaccccctctgccactttcag
tacatctgtagctgcctgcacagcggactgactccccatctgaccatggtccactcctcc
tccatcctcgccatgagggatgagcagagcaaccctgccccccaggtgcagaagccacga
gtcaaacctcccccgatccctgccaagaagccctcctctgtgtccctgtggtccctggaa
cagccattctgcattgagctgattgagggccgcaaggtgaatgcggatgaaaggatgaag
ctggttgtgcaggccgggctcttccacggcaatgagatgctgtgcaagactgtgtcgagc
tcagaggtgaatgtgtgctcagagcccgtgtggaagcagcgactagaattcgacatcagc
atctgtgacctcccccgaatggcccggctctgctttgcactctatgctgtcgtggagaag
gctaagaaggcgcgctccacaaagaagaagtccaagaaggcggactgtcccatcgcttgg
gccaacctcatgctattcgactacaaagatcagctcaagacgggcgaacggtgcctctac
atgtggccctctgtcccagatgagaaaggggaactgatgaatcctgcgggtacagtacgt
ggtaaccccaacacagagagtgccgctgccctggtcatctacctacctgaggtggctccc
caccctgtgtacttccctgctctggagaagatcctggagctggggcgtcacggggagcgt
gggcgcatcacagaggaggagatgctctatttgctgtgctcctggcccgagcttcctgtg
ctgagcgccctggagcttctggactttagttttcctgactgctacgtgggttccttcgcc
atcaagtccctacggaagctgacggatgacgagcttttccagtaccttctgcagctggta
caagtactcaaatatgagtcctacctggactgcgagttgaccaaattcttgttgggccga
gccctggctaaccgcaagatcgggcacttcctgttctggcacctccgctctgagatgcat
gtaccgtccgtggccctgcgttttggcctcatcatggaagcctactgcagaggcagcacc
caccacatgaaggtgctgatgaagcagggggaggcactgagcaagcttaaggccctgaat
gactttgtgaaggcgagctcgcagaagaccaccaagccccagaccaaggagatgatgcat
atgtgtatgcgccaggagacttacatggaggcgctgtcccacctgcagtctcccctcgac
cccagcaccctgctggaggaagtctgtgtggagcagtgcaccttcatggactccaaaatg
aagccattgtggatcatgtacagcagcgagaaggcaggcggtgccggcagcgtgggcatc
atctttaagaacggggatgacctccgccaggacatgctgactctgcagatgatccagctc
atggacttcctatggaagcaggagggcctggacctgaggatgaccccctatggctgcctc
cccaccggagatcgcacaggcctcattgaggtggtcctccactcggacaccatcgccaac
atccagctgaataaaagcaacatggcagccacggctgcgttcaacaaggacgctctgctc
aactggctcaagtctaagaaccctggggaggctctggatcgggccattgaggaattcacc
ctctcctgtgctggctactgtgtggccacatatgtgctgggcatcggtgaccggcacagc
gataacatcatgatcagagagagtgggcagcttttccacattgactttggccactttctg
gggaacttcaagaccaagttcgggatcaaccgggagcgtgtccccttcattctcacctac
gactttgtccacgtgatccagcaggggaagactaacaacagtgagaaatttgaaaggttc
cgaggctactgtgaacgagcctacaccatcctgcggcgtcacgggctgcttttccttcat
ctcttcgccctcatgcgcgcagcaggtctgcctgagcttagctgctccaaagacatccag
actctctggcactag
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