KEGG   Rattus norvegicus (rat): 50689Help
Entry
50689             CDS       T01003                                 

Gene name
Mapk3, ERK1, ERT2, Erk-1, Esrk1, MAPK1, MNK1, Prkm3, p44, p44erk1, p44mapk
Definition
mitogen activated protein kinase 3 (EC:2.7.11.24)
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    50689 (Mapk3)
   04015 Rap1 signaling pathway
    50689 (Mapk3)
   04010 MAPK signaling pathway
    50689 (Mapk3)
   04012 ErbB signaling pathway
    50689 (Mapk3)
   04350 TGF-beta signaling pathway
    50689 (Mapk3)
   04370 VEGF signaling pathway
    50689 (Mapk3)
   04668 TNF signaling pathway
    50689 (Mapk3)
   04066 HIF-1 signaling pathway
    50689 (Mapk3)
   04068 FoxO signaling pathway
    50689 (Mapk3)
   04022 cGMP - PKG signaling pathway
    50689 (Mapk3)
   04151 PI3K-Akt signaling pathway
    50689 (Mapk3)
   04150 mTOR signaling pathway
    50689 (Mapk3)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    50689 (Mapk3)
  Cell growth and death
   04114 Oocyte meiosis
    50689 (Mapk3)
  Cell communication
   04510 Focal adhesion
    50689 (Mapk3)
   04520 Adherens junction
    50689 (Mapk3)
   04540 Gap junction
    50689 (Mapk3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    50689 (Mapk3)
   04620 Toll-like receptor signaling pathway
    50689 (Mapk3)
   04621 NOD-like receptor signaling pathway
    50689 (Mapk3)
   04650 Natural killer cell mediated cytotoxicity
    50689 (Mapk3)
   04660 T cell receptor signaling pathway
    50689 (Mapk3)
   04662 B cell receptor signaling pathway
    50689 (Mapk3)
   04664 Fc epsilon RI signaling pathway
    50689 (Mapk3)
   04666 Fc gamma R-mediated phagocytosis
    50689 (Mapk3)
   04062 Chemokine signaling pathway
    50689 (Mapk3)
  Endocrine system
   04910 Insulin signaling pathway
    50689 (Mapk3)
   04912 GnRH signaling pathway
    50689 (Mapk3)
   04915 Estrogen signaling pathway
    50689 (Mapk3)
   04914 Progesterone-mediated oocyte maturation
    50689 (Mapk3)
   04917 Prolactin signaling pathway
    50689 (Mapk3)
   04921 Oxytocin signaling pathway
    50689 (Mapk3)
   04919 Thyroid hormone signaling pathway
    50689 (Mapk3)
   04916 Melanogenesis
    50689 (Mapk3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    50689 (Mapk3)
   04270 Vascular smooth muscle contraction
    50689 (Mapk3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    50689 (Mapk3)
  Nervous system
   04724 Glutamatergic synapse
    50689 (Mapk3)
   04725 Cholinergic synapse
    50689 (Mapk3)
   04726 Serotonergic synapse
    50689 (Mapk3)
   04720 Long-term potentiation
    50689 (Mapk3)
   04730 Long-term depression
    50689 (Mapk3)
   04723 Retrograde endocannabinoid signaling
    50689 (Mapk3)
   04722 Neurotrophin signaling pathway
    50689 (Mapk3)
  Development
   04320 Dorso-ventral axis formation
    50689 (Mapk3)
   04360 Axon guidance
    50689 (Mapk3)
   04380 Osteoclast differentiation
    50689 (Mapk3)
  Environmental adaptation
   04713 Circadian entrainment
    50689 (Mapk3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    50689 (Mapk3)
   05205 Proteoglycans in cancer
    50689 (Mapk3)
   05203 Viral carcinogenesis
    50689 (Mapk3)
   05210 Colorectal cancer
    50689 (Mapk3)
   05212 Pancreatic cancer
    50689 (Mapk3)
   05214 Glioma
    50689 (Mapk3)
   05216 Thyroid cancer
    50689 (Mapk3)
   05221 Acute myeloid leukemia
    50689 (Mapk3)
   05220 Chronic myeloid leukemia
    50689 (Mapk3)
   05218 Melanoma
    50689 (Mapk3)
   05211 Renal cell carcinoma
    50689 (Mapk3)
   05219 Bladder cancer
    50689 (Mapk3)
   05215 Prostate cancer
    50689 (Mapk3)
   05213 Endometrial cancer
    50689 (Mapk3)
   05223 Non-small cell lung cancer
    50689 (Mapk3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    50689 (Mapk3)
   05020 Prion diseases
    50689 (Mapk3)
  Substance dependence
   05034 Alcoholism
    50689 (Mapk3)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    50689 (Mapk3)
  Infectious diseases
   05132 Salmonella infection
    50689 (Mapk3)
   05133 Pertussis
    50689 (Mapk3)
   05152 Tuberculosis
    50689 (Mapk3)
   05164 Influenza A
    50689 (Mapk3)
   05161 Hepatitis B
    50689 (Mapk3)
   05160 Hepatitis C
    50689 (Mapk3)
   05145 Toxoplasmosis
    50689 (Mapk3)
   05140 Leishmaniasis
    50689 (Mapk3)
   05142 Chagas disease (American trypanosomiasis)
    50689 (Mapk3)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     50689 (Mapk3)
Protein kinases [BR:rno01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   50689 (Mapk3)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   50689 (Mapk3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
1q36
AA seq 380 aa AA seqDB search
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSA
YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLGFRHENVIGIRDILRAPTLEAMRDVY
IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD
LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML
SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS
DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKER
LKELIFQETARFQPGAPEAP
NT seq 1143 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggctccggggggcgggggcggggagcccaggggaactgctggg
gtcgtcccggtggtccccggggaggtggaggtggtgaaggggcagccattcgacgtgggc
ccacgctacacgcagctgcagtacatcggcgagggcgcgtacggcatggtcagctcagca
tatgaccacgtgcgcaagaccagagtggctatcaagaagatcagccccttcgagcatcaa
acctactgtcagcgcacgctgagagaaatccagatcttgctcggattccgccatgagaat
gtcataggcatccgagacatcctcagagcacccaccctggaagccatgagagatgtttac
attgttcaggacctcatggagacggacctgtacaagctgctaaagagccagcagctgagc
aatgaccacatctgctacttcctctaccagatcctccggggcctcaagtacatacactcg
gccaatgtgctgcaccgggacctgaagccctccaatctgcttatcaacaccacctgcgac
cttaagatctgtgattttggccttgcccggattgctgaccctgagcacgaccacactggc
tttctgaccgagtatgtggccacacgctggtaccgagccccagagatcatgcttaactcc
aagggctacaccaaatccattgacatctggtctgtgggctgcattctggctgagatgctc
tccaaccggcctatcttccccggcaagcactacctggaccagctcaaccacattctaggt
atactgggttccccatcccaagaggacctaaattgtatcattaacatgaaggcccgaaac
tacctacagtctctgccctctaaaaccaaggtggcttgggccaagctttttcccaaatct
gactccaaagctcttgacctgctggaccggatgttaacctttaacccaaacaagcgcatc
acagtagaggaagcactggctcacccttacctggaacagtactatgatccgacagatgaa
ccagtggctgaggagccattcacctttgacatggagctggatgatctccccaaggagcgg
ctgaaggagctgatcttccaagagacagcccgcttccagccaggggcaccagaggccccc
taa

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