KEGG R.norvegicus: 56718

Rattus norvegicus (rat): 56718

Entry

56718 CDS R.norvegicus

Gene name Mtor

Definition mechanistic target of rapamycin (serine/threonine kinase)
(EC:2.7.11.1)

Orthology K07203 FKBP12-rapamycin complex-associated protein

Pathway rno04012 ErbB signaling pathway
rno04150 mTOR signaling pathway
rno04910 Insulin signaling pathway
rno04920 Adipocytokine signaling pathway
rno04930 Type II diabetes mellitus
rno05200 Pathways in cancer
rno05214 Glioma
rno05215 Prostate cancer
rno05221 Acute myeloid leukemia

Class Metabolism; Enzyme Families; Protein kinases
Environmental Information Processing; Signal Transduction; ErbB
signaling pathway [PATH:rno04012]
Environmental Information Processing; Signal Transduction; mTOR
signaling pathway [PATH:rno04150]
Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; Adipocytokine signaling
pathway [PATH:rno04920]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Glioma [PATH:rno05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Metabolic Diseases; Type II diabetes mellitus
[PATH:rno04930]

SSDB

Motif Pfam: FAT PI3_PI4_kinase DUF3385 Rapamycin_bind FATC HEAT
PROSITE: PI3_4_KINASE_1 PI3_4_KINASE_2 FAT FATC PI3_4_KINASE_3

Other DBs NCBI-GI: 9845251
NCBI-GeneID: 56718
RGD: 68371
RATMAP: ENSRNOG00000009615
Ensembl: ENSRNOG00000009615
UniProt: P42346

Position 5q36

AA seq 2549 aa
MLGTGPATATAGAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPSSDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPTKSTLVESR
CCRDLMEEKFDQVCQWVLKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVASITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFVIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTTATTAASAAAATSTEGSNSESEAESNESSP
TPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNAKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW

NT seq 7650 nt +upstreamnt +downstreamnt
atgcttgggacaggccctgccacggccaccgccggtgccgccacatctagcaacgtgagc
gttctgcagcagttcgccagtgggctgaagagccggaatgaggagaccagggccaaagca
gccaaggagctccagcactatgtcaccatggaacttcgagagatgagtcaggaggagtct
actcgcttctatgaccagctgaaccatcacatttttgaactggtttccagctcagacgcc
aatgagaggaagggtggcatcttggccattgccagcctcattggagtggaaggtgggaat
tccaccaggattggcagatttgccaactaccttcggaacctcctcccctcaagtgatcca
gttgtcatggagatggcatccaaggccattggccgccttgcaatggcaggggacactttc
actgctgagtatgtggagtttgaagtgaagcgagccttggagtggctgggtgctgaccga
aatgagggccggagacatgcagctgtcctcgttctccgtgagctggccatcagcgtcccc
accttcttcttccagcaagttcagcccttctttgacaacatttttgtggctgtgtgggac
cccaagcaggccatccgtgaaggagctgtggctgcccttcgtgcctgtctgattcttacc
acgcagcgggagccgaaggagatgcagaagcctcagtggtacaggcacacatttgaagaa
gcagagaaaggttttgatgagaccctggccaaagagaagggtatgaaccgagatgatcga
atccacggggccttgctgatcctcaacgagctcgtccgaatcagcagcatggagggagag
cgtctgagagaggagatggaggaaatcacccagcagcagctggtacatgacaagtactgc
aaagacctaatgggctttgggacaaagcctcggcacatcactcccttcaccagcttccag
gctgtgcagccccagcagtcaaacgccttggtgggactgctggggtacagctcccaccaa
ggcctaatggggtttggggcttcccccagccctacaaagtccactctggtggaaagccgt
tgttgcagagacttgatggaagagaaatttgatcaggtgtgccagtgggtgctgaaatgt
aggagcagcaagaactcactgatccaaatgacaatccttaatctgttgccccgcttggct
gcattccgaccgtctgccttcacagatacccagtacctgcaagacaccatgaaccatgtc
ctgagctgtgtcaagaaggaaaaggaacggaccgcagcgttccaggccctagggctgctt
tctgtggcggtgaggtccgagtttaaggtctacctgccccgagtacttgacatcatccga
gcagccctgcctccaaaggactttgcccacaagaggcagaaaactgtgcaggtggatgcc
acagtgttcacgtgcatcagcatgctggcgcgggccatggggccaggcatccagcaggac
atcaaggagctgctggagcccatgttggcagtgggcctgagccctgcgctcactgctgtg
ctctatgacctgagccggcagattccgcagctgaagaaagatattcaggacgggcttctg
aagatgctgtccctggtccttatgcacaaacccctgcggcacccgggcatgcccaaaggc
ctggcccaccagctggcctccccaggtcttaccaccctccctgaggccagcgacgtggcc
agcatcactcttgcccttcgaactctcggcagctttgaatttgaaggccactctctgacc
cagttcgtccgacactgcgcagatcatttcctgaacagtgagcacaaggagatccgcatg
gaagcagcccgcacctgctcccgcctgctcacaccctccatccacctcatcagcggccat
gcccatgtggttagccagaccgcagtgcaagtggtagcagatgtgctcagcaagctgctt
gtggtcggcataacagatcctgatcctgatatccgctactgtgtcttggcctccctggat
gagcgcttcgatgcccacttggcccaggcagaaaacttacaagctctgtttgtggctctg
aatgaccaggtctttgagatccgagagctggccatctgcactgtgggccgactcagtagc
atgaacccagcctttgtcatgcctttcctgcgcaagatgctcatccagattttgacagag
ctggagcacagtggcattgggagaatcaaggagcagagtgcccgcatgctggggcacctg
gtctccaatgccccccgcctcatccgcccctatatggagcctattctgaaggctttaatt
ttgaaactcaaagatccagaccctgacccaaacccgggcgtgatcaataacgtgttggcc
actataggagaactggctcaggttagcggcctggagatgaggaagtgggtggacgagctc
tttgtcatcatcatggacatgctgcaggactcctctcttctggccaaaagacaggtggct
ttgtggaccctgggacagttggtggccagtactggctacgtggtggagccctacaggaag
taccccactctgcttgaagtgctgctgaattttctgaagacggagcagaaccagggcact
cggagagaggccatccgagtgttagggctcctcggggctttggacccctacaagcacaaa
gtgaacatcggcatgattgaccagtcccgagatgcttctgctgtcagcctgtcagaatcc
aagtcaagtcaagattcctctgactacagcaccagtgaaatgctggtcaacatgggaaac
ctgccactggacgagttctaccccgccgtgtccatggtggccttgatgcggatcttccga
gaccagtccctctctcaccaccacaccatggtggttcaggccatcaccttcatcttcaag
tccctggggctcaagtgtgtgcagttcctgccccaggtcatgcccacgttccttaacgtc
atccgagtctgtgatggggccatccgggaatttctgttccagcagctgggaatgctggtg
tcctttgtgaagagccacatccgtccctacatggatgaaatagtcaccctcatgagagaa
ttttgggtcatgaacacctcaatccagagcacaatcattcttctcattgagcaaatcgtg
gtggctcttggaggtgaatttaagctctacctgccccagctgatcccacacatgctgcgt
gtcttcatgcatgacaacagccagggccgcatagtctccatcaagctgttagcagcgatc
cagctgtttggcgccaacctggatgactatctgcacttgttgttgcctccgatcgtgaaa
ttgtttgatgcccctgaagttccactgccgtcgagaaaggcagcgttggagacagtggac
cgcctgacagagtccctggatttcactgactatgcctcccgcatcattcacccgattgtt
cgcacgctagaccagagcccagagctgcgctccacagccatggacaccctgtcttcactt
gtgtttcaactagggaagaagtaccagatcttcattccaatggtgaataaagtccttgtg
cgacaccggatcaatcaccagcgctacgacgtgctgatctgcagaatcgtcaaggggtac
acgcttgctgatgaagaagaagaccctttgatttaccagcatcgaatgctaaggagcagc
cagggagatgccctggccagtggaccagttgaaacaggacccatgaagaaactgcatgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtctccaaggacgactgg
ctggagtggctgcgacgcttgagtctggagctgctgaaggattcctcatcaccttccctg
cgctcatgctgggccctggcccaggcctacaaccccatggccagggatctcttcaacgct
gcgtttgtgtcctgctggtctgaactgaatgaagaccaacaagatgagctcatcaggagc
attgagttggctctcacttctcaagacattgctgaagtcacacaaaccctcttgaacttg
gctgagttcatggagcacagtgacaagggccccctaccactgagagatgacaatggcatc
gtgctgttgggtgagagagctgccaagtgccgggcatatgccaaagcactacactacaaa
gagctggagttccagaaggggcccacgcctgccatacttgagtccctcatcagcattaat
aataaactgcagcagcctgaggcagcgtccggggtgttagagtacgccatgaaacacttc
ggagagctggagatccaggccacctggtatgagaagttgcatgagtgggaggacgccctt
gtggcctacgacaagaagatggacacgaacaaggatgacccagagctgatgctgggccgc
atgcgctgtctcgaggccttgggagaatggggccagcttcatcagcagtgctgtgaaaag
tggactctggttaatgacgagacccaggctaagatggcccggatggctgctgcagcagca
tggggtttaggtcagtgggacagcatggaggagtacacctgtatgattcctcgggatact
cacgatggagcattctacagagcagtgttggcactgcatcaggatctcttctccttggct
caacagtgcattgacaaggccagggacctgctggacgccgagctgactgccatggcaggg
gagagctacagccgagcctatggggccatggtttcttgccacatgctgtccgagctggag
gaggttatccagtacaaactcgtcccggagcgacgggagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtattgtagaggactggcagaaaatcctcatggtccgg
tcccttgtggtcagccctcacgaggacatgagaacctggctcaagtacgcaagcctgtgt
ggcaagagcggcagactggctcttgctcataaaaccttagtgttgctcttgggagttgat
ccatctcggcaacttgaccatcctctgccaacagttcaccctcaagtgacctatgcctac
atgaaaaacatgtggaaaagcgctcggaagattgatgccttccagcacatgcagcacttt
gtgcagaccatgcagcagcaggcccagcacgccattgccacagaggaccagcagcacaag
caggagctgcataagctcatggccaggtgttttctgaaacttggggagtggcagctgaac
ctccagggcatcaacgagagcaccatccccaaggtgctacagtactacagtgctgccaca
gagcatgaccgcagctggtataaggcttggcacgcatgggcagtgatgaactttgaagcc
gtgctacactacaaacatcagaaccaagcccgcgatgagaagaagaaactgcgccatgcc
agcggggccaacatcaccaatgccaccaccactgccaccaccgctgcctccgctgccgct
gccaccagcacagagggcagcaacagtgaaagtgaagccgagagcaatgagagcagcccc
accccgtcccctctgcagaagaaggtcactgaggatttgtccaaaaccctcttgttgtac
actgtccctgctgtccaaggcttcttccgttctatctccttgtcgagaggcaacaacctc
caggatacactcagagtcctcaccttgtggtttgattatggtcactggccagatgtcaat
gaagccctggtggaaggggtgaaggccatacagattgacacttggttacaggttatacct
cagctcattgcaagaattgacacgcccagacccttggtgggccggctcattcaccagctc
ctcacagatattggtcggtaccacccacaggccctcatctaccccctgacggtggcttct
aagtctaccaccacagcccgtcacaatgcagccaacaagatcctgaagaacatgtgcgag
cacagcaacacgctagtccagcaggccatgatggtgagtgaagagctgattcgagtagcc
atcctctggcatgagatgtggcatgaaggcctagaagaggcctctcgcttgtactttggg
gagaggaacgtcaaaggcatgtttgaggtgctggagcccctgcatgctatgatggaacgc
ggtccccagaccctgaaggaaacgtcctttaatcaggcatatggtcgagatttaatggag
gcacaagaatggtgccgaaagtacatgaaatcagggaacgtcaaggacctcacccaagcc
tgggacctctactatcacgtgttcagacggatctccaagcagctaccacagctcacatcc
ctggagctgcagtatgtgtcccccaaacttttgatgtgcagagaccttgaattggctgtg
ccaggaacatatgaccccaaccagccaatcattcgcattcagtccatagccccgtctttg
caagtcatcacatccaagcagaggcctcggaagctgaccctgatgggcagcaatgggcac
gagtttgttttcctcctgaaaggccatgaagatctgcggcaggacgagcgagtgatgcag
ctctttggcctggtgaacacactcctagccaatgacccaacttctcttcgaaagaacctc
agcatccagagatacgccgtcattcctctgtccaccaactcgggcctgattggctgggtg
ccccactgtgacacgctgcatgccctcatccgggactacagagagaagaagaagatcctg
ctgaacatcgagcaccgcatcatgctgcggatggctcctgactatgaccacctgactctg
atgcagaaggtggaggtgtttgagcatgctgtcaacaacacagccggggatgacctggcc
aagctgctgtggctgaaaagccccagctcagaggtgtggtttgaccgaagaaccaattat
actcgctccctggctgtcatgtccatggttggatacattttaggccttggagacaggcac
ccatccaacctgatgctggaccggctgagtggaaagatcctgcacattgactttggggac
tgctttgaggttgctatgaccagagagaaatttccagaaaagattccatttagactaaca
agaatgttgaccaatgctatggaggttaccggtctcgatggcaactatagaaccacatgc
cacacagtgatggaggtgcttcgggagcacaaggacagtgtcatggctgtgctagaagcc
tttgtctatgaccctctgctgaattggaggctgatggacacaaatgccaaaggcaacaag
cggtcccgaaccaggacagactcctattctgcaggccagtcagtagaaattttggacggt
gtagaacttggagaaccagcccataagaaaacagggaccactgtgccagaatccatccat
tctttcattggagatggtttggtgaaaccagaagccttaaacaagaaagctattcagatt
attaacagggttcgagataagctcactggtcgggatttctctcatgatgacactttggat
gttccaacccaagtggaactgcttatcaagcaagcgacatctcatgagaacctctgccag
tgctacattggctggtgtcctttctggtaa

All links

Pathway (9)   
   KEGG PATHWAY (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (2)   
   UNIGENE (1)   
   ENSEMBL-RNO (1)   
   RATMAP-RNO (1)   
   RGD-RNO (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (11)   
   Pfam (6)   
   PROSITE (5)   
All databases (35)

DBGET integrated database retrieval system