KEGG   Rattus norvegicus (rat): 85240Help
Entry
85240             CDS       T01003                                 

Gene name
Plcb2
Definition
phospholipase C, beta 2 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    85240 (Plcb2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    85240 (Plcb2)
   04310 Wnt signaling pathway
    85240 (Plcb2)
   04020 Calcium signaling pathway
    85240 (Plcb2)
   04070 Phosphatidylinositol signaling system
    85240 (Plcb2)
   04022 cGMP - PKG signaling pathway
    85240 (Plcb2)
 Cellular Processes
  Cell communication
   04540 Gap junction
    85240 (Plcb2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    85240 (Plcb2)
   04062 Chemokine signaling pathway
    85240 (Plcb2)
  Endocrine system
   04911 Insulin secretion
    85240 (Plcb2)
   04912 GnRH signaling pathway
    85240 (Plcb2)
   04915 Estrogen signaling pathway
    85240 (Plcb2)
   04921 Oxytocin signaling pathway
    85240 (Plcb2)
   04918 Thyroid hormone synthesis
    85240 (Plcb2)
   04919 Thyroid hormone signaling pathway
    85240 (Plcb2)
   04916 Melanogenesis
    85240 (Plcb2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    85240 (Plcb2)
   04270 Vascular smooth muscle contraction
    85240 (Plcb2)
  Digestive system
   04970 Salivary secretion
    85240 (Plcb2)
   04971 Gastric acid secretion
    85240 (Plcb2)
   04972 Pancreatic secretion
    85240 (Plcb2)
   04973 Carbohydrate digestion and absorption
    85240 (Plcb2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    85240 (Plcb2)
  Nervous system
   04724 Glutamatergic synapse
    85240 (Plcb2)
   04725 Cholinergic synapse
    85240 (Plcb2)
   04728 Dopaminergic synapse
    85240 (Plcb2)
   04726 Serotonergic synapse
    85240 (Plcb2)
   04720 Long-term potentiation
    85240 (Plcb2)
   04730 Long-term depression
    85240 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    85240 (Plcb2)
  Sensory system
   04742 Taste transduction
    85240 (Plcb2)
   04750 Inflammatory mediator regulation of TRP channels
    85240 (Plcb2)
  Environmental adaptation
   04713 Circadian entrainment
    85240 (Plcb2)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    85240 (Plcb2)
   05016 Huntington's disease
    85240 (Plcb2)
  Infectious diseases
   05146 Amoebiasis
    85240 (Plcb2)
   05142 Chagas disease (American trypanosomiasis)
    85240 (Plcb2)
   05143 African trypanosomiasis
    85240 (Plcb2)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     85240 (Plcb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
UniProt: 
Position
3q35
AA seq 1183 aa AA seqDB search
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGV
SEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTA
GLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYN
KRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLL
KHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKR
RYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSG
YHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEV
TGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKG
VVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPC
EETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAR
EKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQE
VVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESM
RACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL
NT seq 3552 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcaaccctgtcctgttgccccctaaggtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacctcaatagcctcccctgttatccttcgggtg
gatcccaagggctattacttatactggacacatcaaagtaaggagatggaatttctggat
gtcacgagcatccgagacactcgctttgggaagtttgccaagatacccaagagccagaaa
ctccgggaggtattcaacatggactttccagacaaccacttcctgctgaaaacattcaca
gtggtatccggcccggacatggtgggcctcaccttccacaattttgtctcttacaaggag
aacgtaggcaaggattgggctgaggatgtactggctctggccaaacacccaatgacagcc
aatgcttctcgaagcacattcctagacaagatcctggtgaagcttaaaatgcagctgagc
cctgaagggaagatccctgtgaagaattttttccagatgtttcctgccgatcgcaaacgt
gtagaagctgccctcagtgcctgtcaccttgcaaaaggcaagaatgatgctatcaatccc
gaggacttcccagaatctgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
attgatgagatcttcacttcttatcatgctaaagccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaatcagaagcaacgagaccctcgactcaattccttgctgttccca
ccagcccggcctgagcaggtgcaggcgctcattgacaagtacgagcccagcggcatcaat
gtgcagaggggccaactgtcaccagagggcatggtctggtttctctgtggaccagagaac
agtgtcctggcccatgatactctgcggatccaccaagacatgacacagcctctgaatcac
tacttcatcaactcctcacacaacacttacctgacagctggccagttttcaggcccttcc
tcggctgagatgtaccgccaggtgctgctatctggctgccgttgtgtagaattagattgt
tggaaaggaaagccccccgacgaagaacccatcatcacccacggcttcactatgaccaca
gatatcttgttcaaggaagcagtcgaagccattgcagaaagtgcctttaagacctcccca
tatcctgtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatg
gccgagtactgccggaccatgtttggagagaccttgctcacagagcccctggaaaacttt
cctctgaaacctggcatgcctctgcctagccctgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccaacaagaagcctgatggggtg
tctgagggcggcttcccatctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggagggagaggaggaggaggaggtggaagaagaggaagaggag
gagtcaggaaacctggatgaagaagaaattaagaagatgcagtctgatgagggcacagca
ggcttggaggtgacagcttatgaggaaatgtccagccttgtcaattacatccagcccacc
aagtttatctccttcgagttctctgcacagaagaacaggagttaccttgtctcttccttc
acggagctcaaggcctacgagctgctctccaaggcctccatgcagtttgtggactataat
aaacgccagatgagccgcgtgtaccccaagggcacgcgcatggactcttccaactacatg
ccccagatgttctggaatgccggatgtcagatggttgccctcaatttccagacaatggat
ctgcccatgcagcagaacatggcactgtttgagttcaacgggcagagtggctacctccta
aagcacgagttcatgcgcaggcaggacaagcagttcaaccccttctcggtggaccgcatt
gatgtggtggttgccactaccctttccattacggtcatctctgggcagttcctgtcagag
cgcagtgtgcgcacctatgtggaagtagaactgtttggcctcccaggggaccccaagagg
cgctatcgtaccaagctgtcacctactgctaactccatcaatcctgtctggaaggaggaa
cccttcatttttgagaagatcttggtgcctgagctggcctccctcaggatagctgtaatg
gaagaaggcggcaaatttattggacatcgcatcatccccatcaatgccttacattccgga
taccaccatctgtgcctgcgcagtgagagcaacatgcctctcaccatgcctgctctcttc
gtcttcctggagatgaaggactatgtacctgacacgtgggcagatcttactgtggctctt
gccaaccccatcaagtacttcagtgcccatgataagaagtctgtgaagctcaaagaagtg
acaggaagtctgcctgagaagctcttctctgggattcctgttgccagccagtccaacggg
gctccagtctccgcaggcaatgggtcaacagcgcctgggaccaaggccaaggaggaagct
acgaaggaagtggcagagccacagaccactagcttggaagagctgcgggagctgaagggc
gtggtgaagctgcagcggagacatgagaaggagcttcgagagctggagcggcgtggagcc
cggcgctgggaggagctgctgcagcgtggcgctgcacagctagcggagctccaggaccca
gcagcaagctgcaagctccgcccgggcaagggctcccgcaagaagaggatcgtgccctgt
gaggagaccatcgtggtgcctagggaggtcctcgagggaccggacccccgcgtgcaggat
ctgaaggacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctctgtc
ctcaagcgtaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccaga
gagaaacaggctgctgaactcaagagcttcaaggagacctcggaaactgacaccaaagag
atgaagaaaaaactggaggccaaaaggctggagcggatccaagccatgaccaaagtcacc
acagacaaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggag
gtggtgcaggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaa
gagaagcagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaag
gcgctggcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcaatg
cgggcttgcttcaaggcctgcttccccacggaagcagaagagaagcctgagaggccctgt
gaggcctctgaggagtcgtgtccacaggagccacttgtgaacaagacagacactcaggag
agccgcctctga

DBGET integrated database retrieval system