KEGG   Rattus norvegicus (rat): 85240Help
Entry
85240             CDS       T01003                                 

Gene name
Plcb2
Definition
(RefSeq) phospholipase C, beta 2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04062  Chemokine signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04261  Adrenergic signaling in cardiomyocytes
rno04270  Vascular smooth muscle contraction
rno04310  Wnt signaling pathway
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04621  NOD-like receptor signaling pathway
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04916  Melanogenesis
rno04918  Thyroid hormone synthesis
rno04919  Thyroid hormone signaling pathway
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04926  Relaxin signaling pathway
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04934  Cushing's syndrome
rno04961  Endocrine and other factor-regulated calcium reabsorption
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno04973  Carbohydrate digestion and absorption
rno05010  Alzheimer's disease
rno05016  Huntington's disease
rno05142  Chagas disease (American trypanosomiasis)
rno05143  African trypanosomiasis
rno05146  Amoebiasis
rno05200  Pathways in cancer
Module
rno_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    85240 (Plcb2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    85240 (Plcb2)
   04310 Wnt signaling pathway
    85240 (Plcb2)
   04371 Apelin signaling pathway
    85240 (Plcb2)
   04020 Calcium signaling pathway
    85240 (Plcb2)
   04070 Phosphatidylinositol signaling system
    85240 (Plcb2)
   04072 Phospholipase D signaling pathway
    85240 (Plcb2)
   04071 Sphingolipid signaling pathway
    85240 (Plcb2)
   04022 cGMP - PKG signaling pathway
    85240 (Plcb2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    85240 (Plcb2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    85240 (Plcb2)
   04621 NOD-like receptor signaling pathway
    85240 (Plcb2)
   04062 Chemokine signaling pathway
    85240 (Plcb2)
  Endocrine system
   04911 Insulin secretion
    85240 (Plcb2)
   04922 Glucagon signaling pathway
    85240 (Plcb2)
   04912 GnRH signaling pathway
    85240 (Plcb2)
   04915 Estrogen signaling pathway
    85240 (Plcb2)
   04921 Oxytocin signaling pathway
    85240 (Plcb2)
   04926 Relaxin signaling pathway
    85240 (Plcb2)
   04918 Thyroid hormone synthesis
    85240 (Plcb2)
   04919 Thyroid hormone signaling pathway
    85240 (Plcb2)
   04928 Parathyroid hormone synthesis, secretion and action
    85240 (Plcb2)
   04916 Melanogenesis
    85240 (Plcb2)
   04924 Renin secretion
    85240 (Plcb2)
   04925 Aldosterone synthesis and secretion
    85240 (Plcb2)
   04927 Cortisol synthesis and secretion
    85240 (Plcb2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    85240 (Plcb2)
   04270 Vascular smooth muscle contraction
    85240 (Plcb2)
  Digestive system
   04970 Salivary secretion
    85240 (Plcb2)
   04971 Gastric acid secretion
    85240 (Plcb2)
   04972 Pancreatic secretion
    85240 (Plcb2)
   04973 Carbohydrate digestion and absorption
    85240 (Plcb2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    85240 (Plcb2)
  Nervous system
   04724 Glutamatergic synapse
    85240 (Plcb2)
   04725 Cholinergic synapse
    85240 (Plcb2)
   04728 Dopaminergic synapse
    85240 (Plcb2)
   04726 Serotonergic synapse
    85240 (Plcb2)
   04720 Long-term potentiation
    85240 (Plcb2)
   04730 Long-term depression
    85240 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    85240 (Plcb2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    85240 (Plcb2)
  Environmental adaptation
   04713 Circadian entrainment
    85240 (Plcb2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    85240 (Plcb2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    85240 (Plcb2)
   05016 Huntington's disease
    85240 (Plcb2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    85240 (Plcb2)
   04934 Cushing's syndrome
    85240 (Plcb2)
  Infectious diseases
   05146 Amoebiasis
    85240 (Plcb2)
   05142 Chagas disease (American trypanosomiasis)
    85240 (Plcb2)
   05143 African trypanosomiasis
    85240 (Plcb2)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     85240 (Plcb2)
Membrane trafficking [BR:rno04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    85240 (Plcb2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    85240 (Plcb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y EF-hand_like C2
Motif
Other DBs
NCBI-GeneID: 85240
NCBI-ProteinID: NP_445930
RGD: 621004
Ensembl: ENSRNOG00000058337
UniProt: O89040
Position
3q35
AA seq 1183 aa AA seqDB search
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGV
SEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTA
GLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYN
KRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLL
KHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKR
RYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSG
YHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEV
TGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKG
VVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPC
EETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAR
EKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQE
VVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESM
RACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL
NT seq 3552 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcaaccctgtcctgttgccccctaaggtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacctcaatagcctcccctgttatccttcgggtg
gatcccaagggctattacttatactggacacatcaaagtaaggagatggaatttctggat
gtcacgagcatccgagacactcgctttgggaagtttgccaagatacccaagagccagaaa
ctccgggaggtattcaacatggactttccagacaaccacttcctgctgaaaacattcaca
gtggtatccggcccggacatggtgggcctcaccttccacaattttgtctcttacaaggag
aacgtaggcaaggattgggctgaggatgtactggctctggccaaacacccaatgacagcc
aatgcttctcgaagcacattcctagacaagatcctggtgaagcttaaaatgcagctgagc
cctgaagggaagatccctgtgaagaattttttccagatgtttcctgccgatcgcaaacgt
gtagaagctgccctcagtgcctgtcaccttgcaaaaggcaagaatgatgctatcaatccc
gaggacttcccagaatctgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
attgatgagatcttcacttcttatcatgctaaagccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaatcagaagcaacgagaccctcgactcaattccttgctgttccca
ccagcccggcctgagcaggtgcaggcgctcattgacaagtacgagcccagcggcatcaat
gtgcagaggggccaactgtcaccagagggcatggtctggtttctctgtggaccagagaac
agtgtcctggcccatgatactctgcggatccaccaagacatgacacagcctctgaatcac
tacttcatcaactcctcacacaacacttacctgacagctggccagttttcaggcccttcc
tcggctgagatgtaccgccaggtgctgctatctggctgccgttgtgtagaattagattgt
tggaaaggaaagccccccgacgaagaacccatcatcacccacggcttcactatgaccaca
gatatcttgttcaaggaagcagtcgaagccattgcagaaagtgcctttaagacctcccca
tatcctgtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatg
gccgagtactgccggaccatgtttggagagaccttgctcacagagcccctggaaaacttt
cctctgaaacctggcatgcctctgcctagccctgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccaacaagaagcctgatggggtg
tctgagggcggcttcccatctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggagggagaggaggaggaggaggtggaagaagaggaagaggag
gagtcaggaaacctggatgaagaagaaattaagaagatgcagtctgatgagggcacagca
ggcttggaggtgacagcttatgaggaaatgtccagccttgtcaattacatccagcccacc
aagtttatctccttcgagttctctgcacagaagaacaggagttaccttgtctcttccttc
acggagctcaaggcctacgagctgctctccaaggcctccatgcagtttgtggactataat
aaacgccagatgagccgcgtgtaccccaagggcacgcgcatggactcttccaactacatg
ccccagatgttctggaatgccggatgtcagatggttgccctcaatttccagacaatggat
ctgcccatgcagcagaacatggcactgtttgagttcaacgggcagagtggctacctccta
aagcacgagttcatgcgcaggcaggacaagcagttcaaccccttctcggtggaccgcatt
gatgtggtggttgccactaccctttccattacggtcatctctgggcagttcctgtcagag
cgcagtgtgcgcacctatgtggaagtagaactgtttggcctcccaggggaccccaagagg
cgctatcgtaccaagctgtcacctactgctaactccatcaatcctgtctggaaggaggaa
cccttcatttttgagaagatcttggtgcctgagctggcctccctcaggatagctgtaatg
gaagaaggcggcaaatttattggacatcgcatcatccccatcaatgccttacattccgga
taccaccatctgtgcctgcgcagtgagagcaacatgcctctcaccatgcctgctctcttc
gtcttcctggagatgaaggactatgtacctgacacgtgggcagatcttactgtggctctt
gccaaccccatcaagtacttcagtgcccatgataagaagtctgtgaagctcaaagaagtg
acaggaagtctgcctgagaagctcttctctgggattcctgttgccagccagtccaacggg
gctccagtctccgcaggcaatgggtcaacagcgcctgggaccaaggccaaggaggaagct
acgaaggaagtggcagagccacagaccactagcttggaagagctgcgggagctgaagggc
gtggtgaagctgcagcggagacatgagaaggagcttcgagagctggagcggcgtggagcc
cggcgctgggaggagctgctgcagcgtggcgctgcacagctagcggagctccaggaccca
gcagcaagctgcaagctccgcccgggcaagggctcccgcaagaagaggatcgtgccctgt
gaggagaccatcgtggtgcctagggaggtcctcgagggaccggacccccgcgtgcaggat
ctgaaggacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctctgtc
ctcaagcgtaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccaga
gagaaacaggctgctgaactcaagagcttcaaggagacctcggaaactgacaccaaagag
atgaagaaaaaactggaggccaaaaggctggagcggatccaagccatgaccaaagtcacc
acagacaaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggag
gtggtgcaggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaa
gagaagcagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaag
gcgctggcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcaatg
cgggcttgcttcaaggcctgcttccccacggaagcagaagagaagcctgagaggccctgt
gaggcctctgaggagtcgtgtccacaggagccacttgtgaacaagacagacactcaggag
agccgcctctga

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