KEGG   Rattus norvegicus (rat): 85243Help
Entry
85243             CDS       T01003                                 

Gene name
Pik3cb
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:rno00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    85243 (Pik3cb)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    85243 (Pik3cb)
   04015 Rap1 signaling pathway
    85243 (Pik3cb)
   04012 ErbB signaling pathway
    85243 (Pik3cb)
   04370 VEGF signaling pathway
    85243 (Pik3cb)
   04630 Jak-STAT signaling pathway
    85243 (Pik3cb)
   04668 TNF signaling pathway
    85243 (Pik3cb)
   04066 HIF-1 signaling pathway
    85243 (Pik3cb)
   04068 FoxO signaling pathway
    85243 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    85243 (Pik3cb)
   04024 cAMP signaling pathway
    85243 (Pik3cb)
   04022 cGMP - PKG signaling pathway
    85243 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    85243 (Pik3cb)
   04152 AMPK signaling pathway
    85243 (Pik3cb)
   04150 mTOR signaling pathway
    85243 (Pik3cb)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    85243 (Pik3cb)
  Cell growth and death
   04210 Apoptosis
    85243 (Pik3cb)
  Cellular commiunity
   04510 Focal adhesion
    85243 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    85243 (Pik3cb)
 Organismal Systems
  Immune system
   04611 Platelet activation
    85243 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    85243 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    85243 (Pik3cb)
   04660 T cell receptor signaling pathway
    85243 (Pik3cb)
   04662 B cell receptor signaling pathway
    85243 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    85243 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    85243 (Pik3cb)
   04670 Leukocyte transendothelial migration
    85243 (Pik3cb)
   04062 Chemokine signaling pathway
    85243 (Pik3cb)
  Endocrine system
   04910 Insulin signaling pathway
    85243 (Pik3cb)
   04915 Estrogen signaling pathway
    85243 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    85243 (Pik3cb)
   04917 Prolactin signaling pathway
    85243 (Pik3cb)
   04921 Oxytocin signaling pathway
    85243 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    85243 (Pik3cb)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    85243 (Pik3cb)
  Digestive system
   04973 Carbohydrate digestion and absorption
    85243 (Pik3cb)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    85243 (Pik3cb)
  Nervous system
   04725 Cholinergic synapse
    85243 (Pik3cb)
   04722 Neurotrophin signaling pathway
    85243 (Pik3cb)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    85243 (Pik3cb)
  Development
   04380 Osteoclast differentiation
    85243 (Pik3cb)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    85243 (Pik3cb)
   05230 Central carbon metabolism in cancer
    85243 (Pik3cb)
   05231 Choline metabolism in cancer
    85243 (Pik3cb)
   05205 Proteoglycans in cancer
    85243 (Pik3cb)
   05203 Viral carcinogenesis
    85243 (Pik3cb)
   05210 Colorectal cancer
    85243 (Pik3cb)
   05212 Pancreatic cancer
    85243 (Pik3cb)
   05214 Glioma
    85243 (Pik3cb)
   05221 Acute myeloid leukemia
    85243 (Pik3cb)
   05220 Chronic myeloid leukemia
    85243 (Pik3cb)
   05218 Melanoma
    85243 (Pik3cb)
   05211 Renal cell carcinoma
    85243 (Pik3cb)
   05215 Prostate cancer
    85243 (Pik3cb)
   05213 Endometrial cancer
    85243 (Pik3cb)
   05222 Small cell lung cancer
    85243 (Pik3cb)
   05223 Non-small cell lung cancer
    85243 (Pik3cb)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    85243 (Pik3cb)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    85243 (Pik3cb)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    85243 (Pik3cb)
   05166 HTLV-I infection
    85243 (Pik3cb)
   05162 Measles
    85243 (Pik3cb)
   05164 Influenza A
    85243 (Pik3cb)
   05161 Hepatitis B
    85243 (Pik3cb)
   05160 Hepatitis C
    85243 (Pik3cb)
   05169 Epstein-Barr virus infection
    85243 (Pik3cb)
   05146 Amoebiasis
    85243 (Pik3cb)
   05145 Toxoplasmosis
    85243 (Pik3cb)
   05142 Chagas disease (American trypanosomiasis)
    85243 (Pik3cb)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     85243 (Pik3cb)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
RGD: 
Ensembl: 
UniProt: 
Position
8q31
AA seq 1070 aa AA seqDB search
MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEEE
ASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSSLPLPLPPKKTRVISHVWGNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYAENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALDNRRIGQFLFWHLRSEVHTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCRYMD
SKMKPLWLVYSNRAFGEDAVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttccgctctataatgcctcctgctatggcagacacccttgacatctgggccgtg
gattcacagatcgcgtctgatggctccatctctgtcgatttccttctgcccactgggatt
tatatccagttggaagtaccccgggaagctaccatttcttatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggacattgactcctatatgttt
gcctgtgtgaatcaaactgccgtatatgaggaacttgaagatgaaacacgaagactttgt
gatgtcagacctttccttccagttctcaaactagtgactagaagctgtgacccagcagaa
aaattggactcaaaaattggagttcttataggaaaaggtcttcatgaatttgatgccttg
aaggatcctgaagtgaatgaatttagaagaaaaatgcgcaagttcagcgaggacaagatt
cagtctctggtggggctgtcttggattgactggctcaagcacacgtacccgcccgagcac
gaaccgtccgtcctggagaacctggaagacaaactttatggagggaagctggttgtggct
gtgcattttgaaaatagccaggatgtatttagttttcaagtgtctcccaatttgaatcct
ataaaaataaatgaattggcaatccagaaacgcctcactattcgcgggaaggaagaggaa
gctagcccctgtgactatgtgttacaggtcagtgggagagtggagtatgtgtttggtgac
catccactgattcagttccagtatatccggaattgtgtaatgaacaggaccctgccccat
ttcatccttgtggaatgttgtaagatcaagaaaatgtatgaacaagaaatgattgccata
gaggctgccatcaaccgaaactcctccagccttcctctccctttaccaccaaagaaaaca
cgagttatttctcatgtctggggcaacaacaaccctttccaaattgtcttggtaaaagga
aataagcttaacacagaagaaaccgtgaaagttcatgtcagagccggactttttcatgga
accgagctcctgtgtaaaaccgtcgtaagctcagagatatcaggaaagaatgaccatatt
tggaatgaacaactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttacgcagttttggataaagtaaaaacgaagaaatcaacaaaaactatt
aatccctctaaatatcagaccatcaggaaagcaggaaaagtgcattatcctgttgcatgg
gtaaacaccatggtttttgacttcaaaggacagctgaggtctggagacgtaatattgcac
agctggtcttcgtttcctgatgagctggaagaaatgctgaaccccatggggactgtgcag
acgaacccatatgctgagaatgcaactgccttgcacattaagtttccggagaacaagaag
cagccttattattacccccccttcgataagatcattgagaaggcagctgagattgccagt
ggagacagtgcgaacgtatcaagtcgtggtgggaaaaagtttcttgctgtactgaaagaa
atcttggacagggaccccctgtctcagctgtgtgagaacgaaatggaccttatttggact
ctacggcaagactgccgagaaaatttcccacagtcactgccaaaactactcctgtcaatc
aaatggaataaacttgaagatgttgctcagcttcaggcgctcctgcagatttggcccaaa
ctgccacccagggaagcactggaactcctggatttcaactatccagaccagtatgtccga
gagtacgctgtaggctgcctgcgacagatgagtgatgaagaactctctcagtatctttta
cagttggtgcaagttttgaagtacgagccttttcttgactgtgccctctccagattccta
ttggaaagagcacttgacaaccggaggattggccagtttctgttttggcatcttaggtca
gaggtgcacactcctgctgtgtccattcagtttggtgtcatcctagaggcatactgtcgg
ggaagcgtggggcacatgaaagtgctttccaaacaggttgaagcactcaataaattaaaa
actttaaatagcttaatcaaattgaatgcgatgaagctgaacagagctaaaggaaaggag
gccatgcacacgtgcttaaaacagagtgcctaccgggaggcgctctctgacctgcagtca
cctctgaacccatgtgtcatcctctcagagctctatgtcgaaaagtgcagatacatggac
tccaagatgaagccgctgtggctggtctacagcaacagggcctttggagaggacgcggtg
ggagtgatcttcaaaaatggcgacgatttgcggcaggacatgctgaccctgcagatgctg
cgcctgatggatctgctgtggaaagaagctggcttggacctgcgaatgctcccctatggc
tgtctagcaacaggagatcgctctggcctcattgaggttgtgagcacctctgagacaatc
gctgacattcagctaaacagtagcaacgtggctgccacagcagccttcaacaaagatgct
ctcctgaactggctcaaggagtacaattctggggacgacctggacagagcgattgaggag
ttcaccctgtcctgtgctggctactgtgtagcctcttatgtccttggcattggtgacagg
cacagtgacaacatcatggtgaagaaaaccggccagctcttccacatagactttgggcat
attcttggaaatttcaaatctaaatttggcattaaaagggaacgagtaccttttattctt
acttatgacttcattcatgtcattcaacaaggaaaaacgggaaacacagaaaaatttggc
aggttccgccagtgctgtgaagacgcgtacctgattttacggcggcatgggaatctcttc
attaccctgtttgcgctgatgttgactgcagggcttcccgagctcacatcagtcaaagat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacag
tttaagcagaagtttgatgaggcactcagggaaagctggaccactaaggtgaactggatg
gctcatacagttcggaaagactacaggtcttag

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