KEGG   Rattus norvegicus (rat): 85384Help
Entry
85384             CDS       R.norvegicus                           
Gene name Sos2
Definition son of sevenless homolog 2 (Drosophila)
Orthology K03099  son of sevenless
Pathway rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04062  Chemokine signaling pathway
rno04320  Dorso-ventral axis formation
rno04510  Focal adhesion
rno04540  Gap junction
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04722  Neurotrophin signaling pathway
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno05200  Pathways in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
Class Environmental Information Processing; Signal Transduction; MAPK
signaling pathway [PATH:rno04010]
Environmental Information Processing; Signal Transduction; ErbB
signaling pathway [PATH:rno04012]
Environmental Information Processing; Signal Transduction; Jak-STAT
signaling pathway [PATH:rno04630]
Cellular Processes; Cell Motility; Regulation of actin cytoskeleton
[PATH:rno04810]
Cellular Processes; Cell Communication; Focal adhesion
[PATH:rno04510]
Cellular Processes; Cell Communication; Gap junction [PATH:rno04540]
Organismal Systems; Immune System; Natural killer cell mediated
cytotoxicity [PATH:rno04650]
Organismal Systems; Immune System; T cell receptor signaling pathway
[PATH:rno04660]
Organismal Systems; Immune System; B cell receptor signaling pathway
[PATH:rno04662]
Organismal Systems; Immune System; Fc epsilon RI signaling pathway
[PATH:rno04664]
Organismal Systems; Immune System; Chemokine signaling pathway
[PATH:rno04062]
Organismal Systems; Endocrine System; Insulin signaling pathway
[PATH:rno04910]
Organismal Systems; Endocrine System; GnRH signaling pathway
[PATH:rno04912]
Organismal Systems; Nervous System; Neurotrophin signaling pathway
[PATH:rno04722]
Organismal Systems; Development; Dorso-ventral axis formation
[PATH:rno04320]
Human Diseases; Cancers; Pathways in cancer [PATH:rno05200]
Human Diseases; Cancers; Colorectal cancer [PATH:rno05210]
Human Diseases; Cancers; Glioma [PATH:rno05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:rno05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:rno05220]
Human Diseases; Cancers; Renal cell carcinoma [PATH:rno05211]
Human Diseases; Cancers; Prostate cancer [PATH:rno05215]
Human Diseases; Cancers; Endometrial cancer [PATH:rno05213]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:rno05223]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: RasGEF RasGEF_N RhoGEF PH Histone Borrelia_lipo_2
PROSITE: RASGEF PRO_RICH NLS_BP PH_DOMAIN DH_2 RASGEF_CAT
         RASGEF_NTER
Motif
Other DBs NCBI-GI: 207113135
NCBI-GeneID: 85384
RGD: 620435
Position 6q24
AA seq 1333 aa AA seqDB search
MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC
LAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
DIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKSSE
IEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQD
ILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLK
ACSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKK
MNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHCQTRLP
GYSSAEYRLKEKFVMRKIQICDKEDACEYKHAFELVSKDENSVIFAAKSAEEKNNWMAAL
ISLHYRSTLDRMLDSVLLKEENEQPLRLPRPDVYRFVVTDSEENIVFEDNLQSRSGIPII
KGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPDPEPTEADKL
ALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLEAFISSV
RGKAMKKWVESIAKIIKRKKQAQANGVSHNITFESPPPPVEWHISRAGQSETFDLMTLHP
IEIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVE
AENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRVL
DDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKR
RKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNC
KQPPRFPRKSTFSLKSPGIRPNASRHGSTSGTFRGHPTPLEREPYKISFSRIAETELEST
VSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKSFFSSCGSLHKL
SEEPLVPPPLPPRKKFDHDAPNSKGAMKSDDDPPAIPPRQPPPPKVKPRAPVLTGTFEGP
VPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSP
STPPPTPSPRIPRRCHLPSPSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPL
YRLPLFENAETPQ
NT seq 4002 nt NT seq  +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccctacgagttcttcagcgaagagaacagcccgaaatggcgg
ggactgttggtcccggccctgcggaaggttcaggagcaagtgcaccccaccctgtcggct
aacgaagagtctctctattacatcgaagaactcatctttcaactgctcaataagctgtgc
ctggctcaaccgaggactgttcaagatgttgaggaacgagttcaaaagacttttcctcat
cctattgataaatgggcaattgctgatgcacagtctgccatagagaaacgaaaacgaaga
aatcctctcttactacctgtggacaaaatccatccttccttgaaggaagttttggggtat
aaagtggactaccatgtatccctctacattgtggctgtattggagtatatctcagcagat
attttgaaattggctggtaattatgtttttaatatccggcattatgaaatatctcagcaa
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgaccaggatgac
gatataggcttggtttctctctgtgaagaggaaccttgttcttctggtgagctaaactat
tatgaccttgttagaactgaaatcgcagaagaaagacagtatctacgggaactgaatatg
atcattaaagtattccgggaagcctttctttcagacaaaaagttgttcaagtcttctgaa
attgaaaagattttcagtaacatttcagatatacatgaactgactgtgaaacttttaggt
ttgattgaagacacagtagaaatgacagatgaaagcagtcctcacccgctagctggtagc
tgctttgaagatttagcagaggagcaggcttttgacccctatgaaacgttatcacaggac
attcttgctccagagtttaatgaccacttcagcaagttgatggccagacctgcagttgct
ctgcactttcagtccattgctgacggctttaaggaggctgttcgatatgtccttccgcgc
ctcatgctggtgccggtgtatcattgttggcattactttgaattattaaagcagttgaaa
gcatgtagcgaagaacaggaagaccgagagtgtttgaatcaggctatcactgccctcatg
aacctccaaggcagcatggaccggatttacaagcagcactcgccaaggcgccggccaggg
gatcctgtttgccttttttacaatcgtcaattaagaagcaagcacctggctatcaaaaaa
atgaatgaaattcagaaaaacattgatgggtgggaaggcaaagatattggacagtgttgt
aatgagttcataatggaaggaccattgaccagaattggtgctaagcatgaaaggcatatt
ttcctcttcgatggcttaatgatcagctgtaaacccaatcattgccagactcgacttcca
gggtatagtagtgcagaatacaggttaaaagagaagtttgtcatgaggaaaattcaaatc
tgtgataaagaagacgcttgtgaatacaaacatgcttttgaattagtatccaaagatgaa
aacagtgtaatatttgctgccaagtcagctgaagagaaaaacaactggatggcagccctt
atctcccttcactatcggagcactctagatagaatgctggactctgtgttactgaaagag
gagaacgagcagcccctgcggctaccgcggccagacgtgtaccgcttcgtggtgacagac
tcagaggagaacatagtttttgaagacaacttgcaaagcagaagtggaatccccattatt
aaaggaggcaccgtggtgaaactgatcgaaaggctaacatatcacatgtatgcagatccc
aattttgttcgtactttccttactacgtatcgttcattttgtaagccacaggaattgcta
agcttgctgatagaacggtttgaaattccagatccagagcctactgaggccgacaaactg
gcgctagagaaaggcgagcagccaatcagcgcagatctgaaaagattccgcaaggaatat
gtccaacccgtgcaacttagggtcttgaatgtctttcgccactgggttgagcatcatttt
tatgactttgaaagagacttggaattgcttgaaagactggaagccttcatttcaagtgta
agagggaaagccatgaagaagtgggtagaatccattgctaaaatcatcaagaggaagaag
caagctcaggccaatggagtaagccataatatcacctttgaaagtccgcctccaccggtt
gaatggcacataagtagggcgggacagtctgaaacctttgaccttatgacacttcatccc
atagagattgcacggcagttaacactcttggaatctgatctctacaggagagtccagcct
tctgaacttgtagggagtgtctggaccaaagaagataaagaaataaattctccaaatcta
ttaaaaatgattcgccatacaacaaacctcactttgtggtttgaaaaatgcattgtggaa
gcagaaaactttgaagaacgggtggcagtgctcagcagaatagtagaaattctgcaagtg
tttcaagatctgaataatttcaatggcgtgttggagatagtcagtgcagtcaattcagtg
tcagtgtacagactagaccacacatttgaggcattgcaggaaaggaagcggagagttttg
gatgacgctgtggaattaagtcaggatcactttaaaaaatacctagtaaaacttaaatca
atcaatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaa
gaagggaacagcgactttctaaagaggaaagggaaagatttgatcaatttcagtaagagg
agaaaagtggctgaaataaccggagagattcagcagtatcagaaccaaccatactgctta
cggacagaaccagagatgaggagattctttgaaaacctcaatcccatgggacttttatct
gaaaaagagtttacagattatttgttcaacaaatctcatgaaattgaaccccgaaactgc
aaacaaccacctcgatttcctaggaagtcaaccttttccttaaaatctcctggaataagg
cccaatgccagccgccatggctctacctcaggcacgttccgaggtcacccaacccctctg
gaaagggagccttataagataagctttagcaggatcgccgagacggagctagaatccacg
gtgtcagcaccgacatctcccaacaccccatccaccccacctgtgtctgcttcttcagac
cacagcgtgtttctagatgtggacctcaatagctcctgtggcagcaataccatctttgct
ccagtcctcttgccacactcaaagtctttcttcagctcatgtggaagtctacacaaactg
agtgaagagccactagttcctcctccgcttccccctcggaaaaagtttgatcacgatgct
ccgaactccaagggagctatgaaatcggatgatgaccctcctgctattccaccaagacaa
ccccctcctccaaaggtaaagccaagagctcctgtcctcacgggtacatttgaagggcct
gtgcccagtccacctccacctcctcccagagaccctcttcctgatactcctccaccagtt
cctcttcggcctccggaacactttataaactgtccgtttaatctccagccgcctccgctg
ggacatcctcacagagacccagactggctcagagacgttagcacatgccctaattcacca
agcactcctccccctacgccctcgccacggattccacgcagatgccatttgcccagcccc
agtcacaacaatcttgctcaccctccagctcctcccgttccaccaaggcagaattcaagc
cctcacctaccaaaactgccaccaaagacttacaagcgggagctttcacacccgccattg
tacagactacctttgtttgaaaatgcagaaactcctcagtga
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