KEGG   Rhinopithecus roxellana (golden snub-nosed monkey): 104655777
Entry
104655777         CDS       T03989                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rro  Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00562  Inositol phosphate metabolism
rro01100  Metabolic pathways
rro04015  Rap1 signaling pathway
rro04020  Calcium signaling pathway
rro04022  cGMP-PKG signaling pathway
rro04062  Chemokine signaling pathway
rro04070  Phosphatidylinositol signaling system
rro04071  Sphingolipid signaling pathway
rro04072  Phospholipase D signaling pathway
rro04261  Adrenergic signaling in cardiomyocytes
rro04270  Vascular smooth muscle contraction
rro04310  Wnt signaling pathway
rro04371  Apelin signaling pathway
rro04540  Gap junction
rro04611  Platelet activation
rro04613  Neutrophil extracellular trap formation
rro04621  NOD-like receptor signaling pathway
rro04713  Circadian entrainment
rro04720  Long-term potentiation
rro04723  Retrograde endocannabinoid signaling
rro04724  Glutamatergic synapse
rro04725  Cholinergic synapse
rro04726  Serotonergic synapse
rro04728  Dopaminergic synapse
rro04730  Long-term depression
rro04742  Taste transduction
rro04750  Inflammatory mediator regulation of TRP channels
rro04911  Insulin secretion
rro04912  GnRH signaling pathway
rro04915  Estrogen signaling pathway
rro04916  Melanogenesis
rro04918  Thyroid hormone synthesis
rro04919  Thyroid hormone signaling pathway
rro04921  Oxytocin signaling pathway
rro04922  Glucagon signaling pathway
rro04924  Renin secretion
rro04925  Aldosterone synthesis and secretion
rro04926  Relaxin signaling pathway
rro04927  Cortisol synthesis and secretion
rro04928  Parathyroid hormone synthesis, secretion and action
rro04929  GnRH secretion
rro04933  AGE-RAGE signaling pathway in diabetic complications
rro04934  Cushing syndrome
rro04935  Growth hormone synthesis, secretion and action
rro04961  Endocrine and other factor-regulated calcium reabsorption
rro04970  Salivary secretion
rro04971  Gastric acid secretion
rro04972  Pancreatic secretion
rro04973  Carbohydrate digestion and absorption
rro05010  Alzheimer disease
rro05016  Huntington disease
rro05017  Spinocerebellar ataxia
rro05022  Pathways of neurodegeneration - multiple diseases
rro05142  Chagas disease
rro05143  African trypanosomiasis
rro05146  Amoebiasis
rro05163  Human cytomegalovirus infection
rro05200  Pathways in cancer
rro05415  Diabetic cardiomyopathy
rro05417  Lipid and atherosclerosis
Module
rro_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rro00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    104655777 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104655777 (PLCB4)
   04310 Wnt signaling pathway
    104655777 (PLCB4)
   04371 Apelin signaling pathway
    104655777 (PLCB4)
   04020 Calcium signaling pathway
    104655777 (PLCB4)
   04070 Phosphatidylinositol signaling system
    104655777 (PLCB4)
   04072 Phospholipase D signaling pathway
    104655777 (PLCB4)
   04071 Sphingolipid signaling pathway
    104655777 (PLCB4)
   04022 cGMP-PKG signaling pathway
    104655777 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104655777 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104655777 (PLCB4)
   04613 Neutrophil extracellular trap formation
    104655777 (PLCB4)
   04621 NOD-like receptor signaling pathway
    104655777 (PLCB4)
   04062 Chemokine signaling pathway
    104655777 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    104655777 (PLCB4)
   04922 Glucagon signaling pathway
    104655777 (PLCB4)
   04929 GnRH secretion
    104655777 (PLCB4)
   04912 GnRH signaling pathway
    104655777 (PLCB4)
   04915 Estrogen signaling pathway
    104655777 (PLCB4)
   04921 Oxytocin signaling pathway
    104655777 (PLCB4)
   04926 Relaxin signaling pathway
    104655777 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    104655777 (PLCB4)
   04918 Thyroid hormone synthesis
    104655777 (PLCB4)
   04919 Thyroid hormone signaling pathway
    104655777 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    104655777 (PLCB4)
   04916 Melanogenesis
    104655777 (PLCB4)
   04924 Renin secretion
    104655777 (PLCB4)
   04925 Aldosterone synthesis and secretion
    104655777 (PLCB4)
   04927 Cortisol synthesis and secretion
    104655777 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104655777 (PLCB4)
   04270 Vascular smooth muscle contraction
    104655777 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    104655777 (PLCB4)
   04971 Gastric acid secretion
    104655777 (PLCB4)
   04972 Pancreatic secretion
    104655777 (PLCB4)
   04973 Carbohydrate digestion and absorption
    104655777 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    104655777 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    104655777 (PLCB4)
   04725 Cholinergic synapse
    104655777 (PLCB4)
   04728 Dopaminergic synapse
    104655777 (PLCB4)
   04726 Serotonergic synapse
    104655777 (PLCB4)
   04720 Long-term potentiation
    104655777 (PLCB4)
   04730 Long-term depression
    104655777 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    104655777 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    104655777 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    104655777 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104655777 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104655777 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    104655777 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    104655777 (PLCB4)
   05142 Chagas disease
    104655777 (PLCB4)
   05143 African trypanosomiasis
    104655777 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104655777 (PLCB4)
   05016 Huntington disease
    104655777 (PLCB4)
   05017 Spinocerebellar ataxia
    104655777 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    104655777 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104655777 (PLCB4)
   05415 Diabetic cardiomyopathy
    104655777 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104655777 (PLCB4)
   04934 Cushing syndrome
    104655777 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rro04131]
    104655777 (PLCB4)
Enzymes [BR:rro01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     104655777 (PLCB4)
Membrane trafficking [BR:rro04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    104655777 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    104655777 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 104655777
NCBI-ProteinID: XP_010353580
Position
13:complement(94026997..94469276)
AA seq 1222 aa
MAGKKGREEKEVLNIIMAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEF
GFFLTWKSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGI
DLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKI
PVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIED
LFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKK
GLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVE
MYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPV
ILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKR
LKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADD
LGHKEAVANSVKKASDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYA
QPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSS
NYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSE
TPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY
NEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLP
TIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKN
DKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHL
KKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCL
EMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKK
LLISAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNS
SNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEQQNEQLLKSCHAVSQSQGEGDAAD
GEIGSRDGPQTSNSSMKLQNAN
NT seq 3669 nt   +upstreamnt  +downstreamnt
atggcagggaagaagggaagggaagaaaaggaggtcttgaatataatcatggccaaacct
tatgaatttaactggcagaaggaagttccttcctttttgcaagaaggagcagtttttgac
agatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaagtggatgagttt
ggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgctagaatgctccctc
atcaacagtattcggtcaggagccataccaaaggatcccaaaatcttggctgctcttgaa
gctgttggaaaatcagaaaatgatctcgaaggtcgaatagtttgtgtctgcagtggcata
gatctagtgaacattagttttacctacatggtggctgaaaatccagaagtaactaagcaa
tgggtagaaggcctgagatcaatcatacacaacttcagggccaacaatgtcagtccaatg
acgtgcctcaagaaacactggatgaaattggcatttatgaccaacacaaatggtaaaatt
ccagttaggagtattactagaacctttgcatcggggaaaacagaaaaggtgatctttcaa
gcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgagcccacggcattt
acttatgaaaagttctatgaactgacacaaaagatttgtcctcggacagatatagaagat
cttttcaaaaaaatcaatggagacaaaactgattatttaacggtagaccaattagtgagc
tttctaaatgaacatcaacgagatcctcgattgaatgaaattttatttccattttatgat
gccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagatttgaagaaaaaa
ggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaaaatgccccagtc
ttcctagatcgtttagaactttaccaagaaatggaccatcctctggctcactacttcatc
agttcttcccataacacttatctgactggcagacagtttggtgggaagtcttcggtagaa
atgtacagacaggttctcctggctggttgcagatgtgttgaacttgactgctgggatgga
aaaggtgaagaccaagaaccaataataactcatgggaaagcaatgtgtacagatatcctt
tttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatcagaatatcctgta
attctctcctttgaaaatcactgcagcaaatatcaacagtacaagatgtccaaatattgc
gaagatctatttggggatctcctgttgaaacaagcgcttgaatcacatccacttgaacca
ggcaggcctttgccatcccccaatgacctcaaaagaaaaatactcataaaaaacaagcgg
ctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatgatggaagctgga
gaatctgcctccccagcaaacatcttagaggatgataatgaagaggagatcgaaagtgct
gaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactttctgctgatgac
ttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagatgaccttgaacat
gaaaacaacaaaaagggtctggtaactgtagaagatgagcaggcatggatggcatcttat
aaatatgtaggtgctaccactaatatccatccatatttgtccacaatgatcaactacgcc
cagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatattcattataacatg
tcttcttttaatgaatcagtcggtcttggctacttgaagacacatgcaattgaatttgtc
aattataacaaacggcaaatgagtcgcatttaccccaagggaggccgagtggattccagt
aattatatgcctcagattttctggaacgctggctgccagatggtttcgctgaactatcaa
accccagatttagcgatgcaattgaatcagggaaaatttgagtataatggatcgtgcggg
taccttctcaaaccagatttcatgaggcggcctgatcgaacatttgaccccttctctgaa
actcctgttgatggcgttattgcagccacttgctcagtgcaggttatatcaggtcaattc
ttatcagataagaaaattggcacctatgtagaagtggatatgtatgggttgcccactgac
accatacgtaaggaattccgaactcgtatggttatgaataatggactaaatccagtttac
aatgaagagtcatttgtatttcggaaggtgatcctgccagacctggctgtcttgagaata
gcagtgtatgatgataacaacaagctgattggccagaggatcctcccacttgatggcctc
caagcaggataccgacacatttcccttcgaaatgagggaaataaaccattatcactgcca
acaattttctgcaatattgttcttaaaacatacgtgcctgatggatttggagatattgtg
gatgctttatcagatccaaagaaatttctctcaattacagaaaagagagcagaccaaatg
agagctatgggaattgaaactagtgacatagccgatgtgcccagtgacacttccaaaaat
gacaagaaaggaaaggccaacaccgccaaagcaaacgtgacccctcagagtagctctgag
ctcagaccaaccaccacagctgccctggcctctggtgtggaagccaagaaaggtattgaa
cttatccctcaagtaaggatagaagatttaaagcagatgaaggcttacttgaagcattta
aagaaacagcagaaagagctaaattctttaaagaagaaacatgcaaaggagcacagtacc
atgcagaagctacactgcacgcaagttgacaaaattgtggcacagtatgacaaagagaag
tcgactcatgagaaaatcctagagaaggcaatgaagaagaaagggggaagtaattgtctt
gaaatgaaaaaagaaacagaaattaaaattcagacgctgacatcagatcacaaatctaag
gtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatcaatacccacagt
gctgaggagcaagaaatccgagacctgcatctcagccagcagtgtgagctgctgaaaaag
ctactcatcagtgcccacgagcaacaaacccagcagctgaaactgtcccatgacagggaa
agcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagcaaagccatcagc
caagataaatctatcaagaataaggcagaacgggaaaggcgagtcagggagttaaacagc
agcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaagcagtccaaagaa
atggatcagttgaaaaaagtccagcttgaacatctagaattcctagagcaacagaatgag
cagcttttgaaatcctgtcatgcagtgtcccaatcgcaaggcgaaggagatgcagcagat
ggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatgaaactccaaaat
gcaaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (15)   
   RefSeq(pep) (15)   
DNA sequence (15)   
   RefSeq(nuc) (15)   
Protein domain (8)   
   Pfam (8)   
All databases (119)   

Download RDF
DBGET integrated database retrieval system