KEGG   Rhinolophus sinicus (Chinese rufous horseshoe bat): 109461386Help
Entry
109461386         CDS       T04863                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor isoform X1
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
rss  Rhinolophus sinicus (Chinese rufous horseshoe bat)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:rss00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    109461386 (INSR)
   04015 Rap1 signaling pathway
    109461386 (INSR)
   04010 MAPK signaling pathway
    109461386 (INSR)
   04066 HIF-1 signaling pathway
    109461386 (INSR)
   04068 FoxO signaling pathway
    109461386 (INSR)
   04072 Phospholipase D signaling pathway
    109461386 (INSR)
   04022 cGMP - PKG signaling pathway
    109461386 (INSR)
   04151 PI3K-Akt signaling pathway
    109461386 (INSR)
   04152 AMPK signaling pathway
    109461386 (INSR)
   04150 mTOR signaling pathway
    109461386 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    109461386 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    109461386 (INSR)
   04923 Regulation of lipolysis in adipocyte
    109461386 (INSR)
   04913 Ovarian Steroidogenesis
    109461386 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109461386 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    109461386 (INSR)
   04213 Longevity regulating pathway - multiple species
    109461386 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    109461386 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    109461386 (INSR)
   04931 Insulin resistance
    109461386 (INSR)
Enzymes [BR:rss01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     109461386 (INSR)
Protein kinases [BR:rss01001]
 Tyrosine protein kinases
  InsR family [OT]
   109461386 (INSR)
Enzyme-linked receptors [BR:rss01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   109461386 (INSR)
Cytokine receptors [BR:rss04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   109461386 (INSR)
CD molecules [BR:rss04090]
 Proteins
  109461386 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Unknown
AA seq 1378 aa AA seqDB search
MGAGGRRGAAAAPLLVAVATLLMGAVGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVDTCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLHLIRGDTL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSFDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVHTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSDYEESGGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKSSSGPGAEDSRPSRKRRALGDVGNGTTVIPTVADF
PNISLTSTPTSSEEHRPFEKVMNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
SRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR
EKISLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNEAASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPDRLTELMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME
FEDMESVPLDRSSHSQREEDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNPS
NT seq 4137 nt NT seq  +upstreamnt  +downstreamnt
atgggcgctgggggcaggcggggggcggccgctgcgccgctgctggtggctgtggccacg
ctgctgatgggcgccgtgggccacctgtaccctggagaggtgtgccctggcatggatatc
cggaacaacctcacgaggttgcacgagcttgccaactgctcggtcattgaaggacatttg
cagatactgttgatgttcaaaacgaggcctgaggatttccgagacctcagtttccccaaa
ctcatcatgatcaccgattacttgctgctattccgggtctacgggctggagagcctgaag
gacctgttccctaacctcacggtcatcaggggctcccgtctcttcttcaactacgcgctg
gtcatcttcgagatggttcacctgaaggagctcggcctctacagcctgatgaacatcacc
cggggttctgtccgcatcgagaagaacaacgagctctgctacctggccaccatcgactgg
tcacgcatcctggattcggtggaggataattacatagtgctgaacaaagacgacaacgag
gagtgtggggacatctgtccaggcaccgcgaagggcaagaccaattgccctgccaccgtt
atcaacgggcagtttgttgagcggtgttggactcacagccattgccagaaagtctgcccc
accatctgtaagtctcacggctgcaccgctgaaggcctctgctgccacagtgagtgcctg
ggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctatctg
gacggcaggtgtgtggacacctgcccacctccgtactatcacttccaagactggcgctgc
gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggagacagggc
tgccaccagtatgtcattcataacaacaagtgcatccctgagtgtccctctggatacacg
atgaattctagcaacttgatgtgcactccgtgtctgggcccctgtcccaaggtctgtcac
ctcctagaaggcgagaagaccatcgactcggtgacgtctgcccaggagctgcgaggctgc
actgtcatcaatggaagccttatcatcaacattcgaggcggcaacaacctggcagctgag
ctagaggccaacctcggcctcattgaagaaatttcagggtatctgaaaatccgccgttcc
tatgcccttgtgtcactttccttcttccggaagttacatctgattcggggggataccttg
gaaatcgggaactactcattctatgccttggacaaccagaacctaaggcaactgtgggac
tggagcaaacacaacctcaccatcactcaggggaaactcttcttccattataatcccaaa
ctctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggaa
aggaacgacattgccctgaagaccaatggggaccaggcatcctgtgaaaatgaattactt
aaattttcttatattcggacatcttttgataagatcttgctgaagtgggagccatactgg
cctcctgacttccgagacctcctggggttcatgctgttctacaaagaggccccttatcag
aatgtgacggagttcgatgggcaggatgcatgtggctccaacagctggacagtggtggac
attgaccctcccctgaggtccaacgaccctaagtcgcagaaccaccctggatggctgatg
cggggtttgaagccctggacccaatacgccatctttgtcaagaccttggttaccttttct
gacgaacggcgcacatatggggcaaagagcgacatcatctatgtccacacagatgccacc
aatccttctgtccccctggatcccatctcagtttctaattcctcatcccagattatcctg
aagtggaagcctccctctgatcccaatggcaacatcactcactacctggttttctgggag
aggcaggcggaagacagtgagctgtatgagctggattattgcctcaaagggttgaagctg
ccctcccggacctggtctccaccgttcgagtcggagggttcccagaagcacaaccagagc
gactacgaggagtctggcggcgagtgctgctcctgcccgaagactgactctcagatcctg
aaggagctggaggagtcctcgttcaggaagacgtttgaggactacctgcacaacgtggtt
ttcgtccccagaaaatcctcttcaggccctggtgctgaggacagtaggccgtcgaggaaa
cgcagggcccttggcgacgtgggaaatgggacgacagtcatacccacagttgcggatttc
cccaatatctccttgaccagcacgcccacgagctcggaggagcaccggccctttgagaaa
gtaatgaacaaagagtcgctggtcatctccggccttcgccacttcaccggctatcgcatt
gagctgcaggcttgcaaccaagattcccctgaggaaaggtgcagcgtggctgcctatgtc
agcgccaggaccatgcccgaagccaaggcagatgacattgtgggccccgtgacccatgaa
atcttcgagaacaacgttgttcacttgatgtggcaggagccaaaggaacccaatggtctg
attgtgctgtacgaagtgagttatcggcggtacggcgatgaggagctgcacctctgtgtc
tcccgcaggcattttgctctggagcggggctgcaggttgcgtgggctgcctccagggaat
tacagcgtgcgagtccgggccacctccttggcgggcaacggctcctggacggaagccacc
tatttctatgtgacagactatttagacgtcccatcaaatattgcaaaaattatcattggt
cccctcatctttgtcttcctcttcagtgttgtgattggaagtatttatctattcctgaga
aagaggcagccggatgggccactgggaccactgtatgcttcttcaaaccctgagtacctc
agtgccagcgatgtgttcccatgttctgtgtacgtgccggacgagtgggaggtgcctcgc
gagaagatcagcctcctgcgagagctgggccagggctccttcggcatggtgtacgagggc
aacgccaaggacatcatcaaaggggaggcggagacccgcgtggcggtgaagacggtcaac
gaggcggccagtctgcgtgagcggatcgagtttctcaacgaggcctccgtcatgaagggc
ttcacctgccatcacgtggtccgcctcctaggggtggtgtccaaagggcagccaacgttg
gtggtaatggagctgatggctcacggagacctgaagagctacctccgttccctgcggcct
gaagctgagaataaccccggccgccctcccccgactttgcaagagatgattcagatggca
gcagagatcgccgacgggatggcatacctgaacgccaagaagtttgtgcaccgggacctt
gcagctcgaaactgcatggtcgcgcatgattttaccgtcaaaatcggagactttggaatg
accagagacatctacgaaacggattactaccggaaagggggcaagggtctactccccgtg
cggtggatggcacccgaatccctgaaggacggggtcttcaccacttcttccgacatgtgg
tcctttggtgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctg
tctaatgagcaggtgttgaaatttgtcatggatggagggtatttggatcaacctgacaac
tgtccagatagactcactgaactcatgcgcatgtgctggcagttcaaccccaagatgcgg
ccgaccttcctggagatcgtcgacctgctcaaggacgacctgcacccaagctttccggaa
gtttccttcttccacagtgaggagaacaaggcacccgagagcgaggaattggaaatggag
tttgaggacatggagagcgtccccctggaccggtcctcacactctcagagggaggaggac
ggagggtcctcgttggggctgaagcggaattacgaggaacacatcccctacacccacatg
aatgggggcaagaaaaacggacgcatcctgactctgccacggtccaatccttcctaa

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